Cross talk between angiotensin-(1–7)/Mas axis and sirtuins in adipose tissue and metabolism of high-fat feed mice

Andrade, João Marcus Oliveira; Paraíso, Alanna Fernandes; Menezes‐Garcia, Zélia; Ferreira, Adaliene Versiani Matos; Sinisterra, Rubén D.; Sousa, Frederico B. De; Guimarães, André Luiz Sena; Paula, Alfredo Maurício Batista de; Campagnole‐Santos, Maria José; Santos, Robson; Santos, Sérgio Henrique Sousa

doi:10.1016/j.peptides.2014.03.006

Cited by 72 publications

(61 citation statements)

References 58 publications

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“…As previously reported, increasing Ang‐(1‐7) levels could upregulate the expression of adiponectin and AMPK in wild‐type cells or rodents . Adiponectin is a well‐established activator of AMPK .…”

Section: Discussionsupporting

confidence: 59%

Angiotensin‐(1‐7) improves non‐alcoholic steatohepatitis through an adiponectin‐independent mechanism

Tang

Zou

et al. 2016

Hepatology Research

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Section: Discussionsupporting

confidence: 59%

Angiotensin‐(1‐7) improves non‐alcoholic steatohepatitis through an adiponectin‐independent mechanism

Tang

Zou

et al. 2016

Hepatology Research

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“…ACE2-Ang(1-7) axis expression has been found to be downregulated in obesity [11], and hepatic and experimental renal ACE2-Ang(1-7) deficiency enhanced high-fat diet-induced NASH, adipose tissue inflammation, and CKD [12], whereas Ang(1-7) analogs or ACE2 activators diminazene and xanthenone reversed these changes and ameliorated adipose tissue dysfunction, vascular inflammation, and liver and kidney disease [13][14][15][16][17]. Therefore, approaches expression, depending on the methylation sites.…”

Section: The Renin-angiotensin System (Ras) In Liver and Kidney Diseasementioning

confidence: 99%

Emerging Liver–Kidney Interactions in Nonalcoholic Fatty Liver Disease

Musso

Cassader

Cohney

et al. 2015

Trends in Molecular Medicine

107

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“…It has been reported that the protein content of SIRT1 was increased with concomitant reduction of acetylation status of Foxo1 in the skeletal muscle of diabetic patients following a 3-month intake of epicatechin-containing drink [58]. Recent efforts have also unraveled that resveratrol elevated the protein contents of phospho-Foxo1 and GLUT4 in the adipose tissues of high-fat diet-fed mice [59]. However, it merits further investigation whether these findings could be extrapolated in conjunction with potential involvements of acetylation/deacetylation of Foxo1 in the aging skeletal muscle.…”

Section: Resveratrol May Confer Anti-hyperglycemic Effects Through Momentioning

confidence: 99%

Modulation of SIRT1-Foxo1 Signaling axis by Resveratrol: Implications in Skeletal Muscle Aging and Insulin Resistance

Sin

Yung

Siu

2015

Cell Physiol Biochem

119

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Aging individuals and diabetic patients often exhibit concomitant reductions of skeletal muscle mass/strength and insulin sensitivity, suggesting an intimate link between muscle aging and insulin resistance. Foxo1, a member of the FOXO transcription factor family, is an important player in insulin signaling due to its inhibitory role in glucose uptake and utilization in skeletal muscle. Phosphorylation of Foxo1 is thought to mitigate the transactivation of pyruvate dehydrogenase lipoamide kinase 4 (PDK4), which is a negative regulator of the glycolytic enzyme pyruvate dehydrogenase (PDH). In contrast, how aging would regulate acetylation/deacetylation machineries and glucose utilization in skeletal muscle through the Foxo1/PDH axis remains largely undetermined. Accumulating body of evidence have shown that resveratrol, a natural polyphenol in grapes and red wine, activates the longevity-related protein sirtuin 1 (SIRT1) and augments insulin sensitivity in addition to its well-documented effects on mitochondrial energetics. The present review summarizes the role of Foxo1/SIRT1 in insulin signaling in skeletal muscle and proposes the insight that activation of SIRT1 deacetylase activity to deacetylate and suppress the Foxo1-induced transactivation of PDK4 may represent an anti-hyperglycemic mechanism of resveratrol in aging skeletal muscle.

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Cross talk between angiotensin-(1–7)/Mas axis and sirtuins in adipose tissue and metabolism of high-fat feed mice

Cited by 72 publications

References 58 publications

Angiotensin‐(1‐7) improves non‐alcoholic steatohepatitis through an adiponectin‐independent mechanism

Angiotensin‐(1‐7) improves non‐alcoholic steatohepatitis through an adiponectin‐independent mechanism

Emerging Liver–Kidney Interactions in Nonalcoholic Fatty Liver Disease

Modulation of SIRT1-Foxo1 Signaling axis by Resveratrol: Implications in Skeletal Muscle Aging and Insulin Resistance

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