Cross-species single-cell RNA sequencing reveals divergent phenotypes and activation states of adaptive immunity in human carotid and experimental murine atherosclerosis
Hauke Horstmann,
Nathaly Anto Michel,
Xia Sheng
et al.
Abstract:Background and Aims
The distinct functions of immune cells in atherosclerosis have been mostly defined by preclinical mouse studies. Contrastingly, the immune cell composition of human atherosclerotic plaques and their contribution to disease progression is only poorly understood. It remains uncertain whether genetic animal models allow for valuable translational approaches.
Methods and Results
Single cell RNA-sequencing (scR… Show more
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