Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion moleculesbeat-Ia/CADM2
Kyla Mace,
Amber Zimmerman,
Alessandra Chesi
et al.
Abstract:Idiopathic hypersomnia (IH) is a poorly-understood sleep disorder characterized by excessive daytime sleepiness despite normal nighttime sleep. Combining human genomics with behavioral and mechanistic studies in fish and flies, we uncover a role for beat-Ia/CADM2, synaptic adhesion molecules of the immunoglobulin superfamily, in excessive sleepiness. Neuronal knockdown of Drosophila beat-Ia results in sleepy flies and loss of the vertebrate ortholog of beat-Ia, CADM2, results in sleepy fish. We delineate a dev… Show more
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