Cross-species comparison of chemical inhibition of human and Xenopus iodotyrosine deiodinase

Olker, Jennifer H.; Korte, Joseph J.; Haselman, Jonathan T.; Hornung, Michael W.; Degitz, Sigmund J.

doi:10.1016/j.aquatox.2022.106227

Cited by 5 publications

(1 citation statement)

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“…IYD is known as a type of deiodinase enzyme that scavenges iodide by removing it from the thyroid gland. Iodide is used for the biosynthesis of thyroid hormone [ 9 , 10 ]. Via an enzyme reaction, iodine is configured to monoiodotyrosine (MIT) and diiodotyrosine (DIT) by binding to tyrosine residues.…”

Section: Introductionmentioning

confidence: 99%

Antibodies Regulate Dual-Function Enzyme IYD to Induce Functional Synergy between Metabolism and Thermogenesis

Kang

Park

Han

2022

IJMS

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Iodotyrosine deiodinase (IYD) is a type of deiodinase enzyme that scavenges iodide from the thyroid gland. Previously, we showed that H3 Ab acts as an agonist on IYD to induce migration of cells to the heart and differentiate human stem cells into brown adipocyte-like cells. To continue this study, we investigated the dual function of IYD in hypothyroidism by blocking IYD and in thermogenesis by looking at the induction of brown adipocyte-like cells by treatment with H3 Ab in a mouse model. Surprisingly, our results suggest H3 Ab acts on IYD as both an antagonist and agonist to reduce T4 and increase core body temperature in the mouse model. Taken together, the data suggest IYD has a dual function that can regulate physiological metabolism and enhance thermogenesis.

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Section: Introductionmentioning

confidence: 99%