Abstract:Bacteria and their viruses (phages) use quorum sensing (QS) systems to coordinate group behavior. In Staphylococcus aureus, QS plays a critical role in the transition from colonization to infection and involves the accumulation of auto-inducing peptides (AIPs). Humans and animals are also colonized by non-aureus staphylococci (NAS) that produce AIPs, many of which inhibit S. aureus QS. We found that QS induction is necessary for S. aureus susceptibility to the lytic phage, Stab20 and that in mixed communities … Show more
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