Cross Species Analysis and Comparison of Tumors in Dogs and Cats, by Age, Sex, Topography and Main Morphologies. Data from Vet-OncoNet

Pinello, Kátia Cristina; Pires, Isabel; Castro, A C Meira; Carvalho, Paulo Tiago; Santos, Andreia; Matos, Augusto de; Queiroga, Felisbina L.; Canadas, Ana; Dias‐Pereira, Patrícia; Catarino, José; Faísca, Pedro; Branco, Sandra; Lopes, Cristiana; Marcos, Filipa; Peleteiro, Maria C.; Pissarra, Hugo; Ruivo, Pedro; Magalhães, Rui; Severo, Milton; Niza-Ribeiro, João

doi:10.3390/vetsci9040167

Cited by 22 publications

(38 citation statements)

References 44 publications

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“…Findings from this study showed that neoplasms were more common in male dogs (57.1%) than in female dogs (42.9%) whereas in cats, it was more common in females (66.7%) than in males (33.3%). Several studies on the prevalence of neoplasms in dogs and cats reported a higher prevalence in females than males and attributed it to the preponderance of mammary gland tumors in females [3,6,13,14,15]. However, no case of mammary gland tumor was recorded in female dogs in this study, which could probably be the reason why the prevalence of neoplasms was higher in male dogs.…”

Section: Discussioncontrasting

confidence: 55%

“…This suggests that dogs may be more susceptible to neoplasms than cats. A higher prevalence of neoplasms in dogs compared to cats is commonly reported [4,6].…”

Section: Discussionmentioning

confidence: 99%

“…Diagnosis of neoplasm usually starts by clinical examination or at postmortem and is confirmed b y c y t o l o g y , h i s t o p a t h o l o g y , a n d immunohistochemistry [3,4,5,6]. Other diagnostic tools include the use of molecular techniques or the use of medical imaging techniques such as X-rays, computed tomography (CT) scans, and magnetic resonance imaging (MRI) [7].…”

Section: Introductionmentioning

confidence: 99%

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A Retrospective Study of Neoplasms of Companion Animals In Abuja, Nigeria

Sani

Saulawa

Ugochukwu

et al. 2022

JVBS

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Neoplasms constitute a major health challenge in animals and man worldwide. However, to the best of our knowledge, the prevalence of neoplasms in companion animals in Abuja, Nigeria, has not been determined. This study was therefore conducted to determine the prevalence of neoplasms in companion animals in Abuja, Nigeria. Case records from 2015 to 2020 from two renowned Veterinary Clinics in Abuja, were examined for cases of neoplasms. Data on the species, breed, sex, age, month and year of occurrence, organ(s) affected, methods of diagnosis, and treatment approach, were extracted and summarized into percentages. A total of 24 cases were recorded with 21 (87.5%) in dogs and 3 (12.5%) in cats. The highest prevalence of neoplasms was in German Shepherd (19.1%) followed by Boerboel (14.3%) and Caucasian (9.5%). In dogs, the prevalence of neoplasms was higher in males (57.1%) than females (42.9%), whereas in cats, the prevalence was higher in females (66.7%) than males (33.3%). The mean age of dogs diagnosed with neoplasms in this study was 6.56 years (SEM=1.21) while the mean age of affected cats was 10 years (SEM=0.00). The commonest types of neoplasms in dogs were papilloma (38.1%) and mast cell tumor (28.6%). The three neoplasms diagnosed in cats were mammary gland carcinoma (33.3%), lipoma (33.3%), and fibrosarcoma (33.3%). In dogs, 90.5% of the cases of neoplasms were diagnosed by physical examination only. However, in addition to physical examination in cats, 66.7% of the cases of neoplasms were diagnosed by histopathology, while 33.3% of the cases were diagnosed by ultrasonography. In this study, surgical excision was the commonest method of treatment of neoplasms in both dogs (76.2%) and cats (66.7%). There is a need for the provision of diagnostic facilities to aid the confirmatory diagnosis of neoplasms in dogs and cats in the study area.

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Section: Discussioncontrasting

confidence: 55%

“…This suggests that dogs may be more susceptible to neoplasms than cats. A higher prevalence of neoplasms in dogs compared to cats is commonly reported [4,6].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Retrospective Study of Neoplasms of Companion Animals In Abuja, Nigeria

Sani

Saulawa

Ugochukwu

et al. 2022

JVBS

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“…Lipomas present in the database were removed from this study. The topographies were grouped into 14 systems, as per our previous study [ 24 ]. The tumors on “Soft Tissue” represent tumors occurring in the connective, subcutaneous, and other soft tissues, when this information was available, according to Vet-ICD-O.…”

Section: Methodsmentioning

confidence: 99%

Vet-OncoNet: Malignancy Analysis of Neoplasms in Dogs and Cats

Pinello

Amorim

Pires

et al. 2022

Veterinary Sciences

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Analysis of canine and feline tumor malignancy data can help clinicians identify high-risk patients and make more accurate decisions. Based on a sample of 16,272 cancer records, including 3266 cats and 13,006 dogs, collected from January 2019 to December 2021 in the Vet-OncoNet Network database, this study aimed to compare the tumor malignancy profile between cats and dogs, considering animal-related factors (sex, age, and breed), topography, and geographic location using a mixed-effects logistic regression model. Cats had a higher proportion of malignant tumors (78.7%) than dogs (46.2%), and the malignancy profile was very different regarding tumors’ topographies. The mean age of malignant tumors occurred eight months later than benign ones (9.1, SD = 3.4; 9.8, SD = 3.2), in general. Species (OR = 3.96, 95%CI 3.57: 4.39) and topography (MOR = 4.10) were the two most important determinants of malignancy risk. Female dogs had a higher risk than male dogs (OR = 1.19, 95%CI 1.08: 1.31), which does not appear to be the case in cats (OR = 0.98, 95%CI 0.77: 1.23). Breed contributed significantly to differences in malignancy risk in dogs (MOR = 1.56), particularly in pit bulls and boxers. District of residence was not so relevant in predicting malignancy risk (MOR = 1.14). In both species, the risk of malignancy increased by approximately 20% every three years. It could be hypothesized that species differences in genetic structure may contribute to tumor malignancy.

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“…Skin cancers are also among the most commonly diagnosed diseases in animals. The canine species has been identified as the species with the highest prevalence of skin malignancies, accounting for one-third of all tumors diagnosed in it [ 4 ]. In the case of cats, skin cancers play a crucial role, accounting for one-quarter of all neoplasias diagnosed in this species.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Tumor Growth and Modulation of Antioxidant Activity of Rhodoxanthin Isolated from Taxus baccata Aril against B16F10 Murine Malignant Melanoma

et al. 2022

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Malignant melanoma is the most aggressive type of skin cancer, and due to the numerous limitations of current treatment methods, there is an urgent need to develop novel approaches for both the prevention and treatment of malignant melanoma, with research-oriented bioactive substances representing a notable first step. The current study decided to expand on previous rhodoxanthin research by investigating the possible anti-tumor effect as well as the effect on the antioxidant status in the case of murine melanoma in an experimental model. The 21-day study was carried out on female C57BL/6J mice. On the first day of the experiment, they were subcutaneously inoculated with 106 B16F10 cells and were given rhodoxanthin orally until the end of the study. Rhodoxanthin supplementation significantly reduced tumor growth (42.18%) and weight (15.74%). Furthermore, the epidermal growth factor (EGF) activity was reduced and the concentration of 8-OHdG dropped in the treated melanoma-bearing mice compared to the untreated ones, demonstrating the role of rhodoxanthin in slowing tumor growth, one of the mechanisms being the reduction of EGF level and the decrease of DNA oxidation. The administration of rhodoxanthin determined variations in antioxidant enzymes, both at the plasma level and at the tissue level.

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Cross Species Analysis and Comparison of Tumors in Dogs and Cats, by Age, Sex, Topography and Main Morphologies. Data from Vet-OncoNet

Cited by 22 publications

References 44 publications

A Retrospective Study of Neoplasms of Companion Animals In Abuja, Nigeria

A Retrospective Study of Neoplasms of Companion Animals In Abuja, Nigeria

Vet-OncoNet: Malignancy Analysis of Neoplasms in Dogs and Cats

Inhibition of Tumor Growth and Modulation of Antioxidant Activity of Rhodoxanthin Isolated from Taxus baccata Aril against B16F10 Murine Malignant Melanoma

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