Cross-sectional Survey on Online Learning during COVID-19 Pandemic in Bangladesh

Bhattacherjee, Devaroti; Akash, Sajidur Rahman; Saiky, Sanjida Islam; Chaity, Nur E Naznin; Islam, Md. Ariful; Jahan, Nusrat; Chowdhury, Imtiaj Hossain

doi:10.22270/jddt.v11i6.5083

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…10 Acmella oleracea is the only member of the genus Acmella and may be responsible for much of its biological activity due to the presence of lipophilic N-alkylamines. 11 The primary alkamide in the aerial sections, spilanthol (affinin), is what gives the plant its medicinal properties, such as anaesthetic 12 and anti-inflammatory effects 5 , immunological stimulation 13 , and saliva-secretion induction. We have chosen the methanol extract of Acmella oleracea leaves to examine the antioxidant, cytotoxic, thrombolytic, and antibacterial contents.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Pharmacological Activities of Methanol Extract of <em>Acmella oleracea</em> Leaves: A Variety Grown in Dhaka, Bangladesh

Alam¹,

Akash²

2023

Preprint

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Acemella oleracea is known as toothache plant belongs to the family of Asteraceae. It is treated as a medicinal remedy like tuberculosis, illness, cough, rheumatism, and illness. This study was concentrated on the antioxidant, cytotoxic, antimicrobial & thrombolytic activities of methanol extract of Acmella oleracea leaves using in vitro model. The antioxidant activity was estimated as trolox equivalent antioxidant capacity utilizing the DPPH and reducing power tests. The plant extract was tested for its cytotoxic action using a brine shrimp lethality bioassay, thrombolytic activity using clot disruption, and antibacterial activity using a disc diffusion assay technique against four distinct gram-positive and gram-negative bacteria. IC50 value of standard ascorbic acid for DPPH was 7.8µg/ml and the IC50 of the methanol extract of Acmella oleracea leaves was 198.34µg/ml that was moderate effect at all compare with ascorbic acid. Thrombolytic assay of Streptokinase as a positive control showed 88.49% where the extract shows 18.69% lytic activity shows the assay. In this study, the sample of LC50 results of cytotoxicity assay was 1.431 µg/mL which can be treated as less activity. Moreover, the extracts showed low to moderate antibacterial activity against both gram-negative and gram-positive bacterial stains (zone of inhibition-10-26 mm). Vibrio Mimicus bacteria stains exhibited the highest level of activity, with a range of 23 for the diameter of the growth inhibition zone. The current review shows leaf extracts of Acmella oleracea may be used as a source of antioxidant and thrombolytic activity, as well as a significant source of antibacterial and anticancer substances. Further research is required to evaluate in-vivo the pharmacological activity of Acmella oleracea leaves in order to identify the essential metabolites and potential mechanisms.

show abstract

Section: Introductionmentioning

confidence: 99%

In Vitro Pharmacological Activities of Methanol Extract of <em>Acmella oleracea</em> Leaves: A Variety Grown in Dhaka, Bangladesh

Alam¹,

Akash²

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…10 Acmella oleracea is the only member of the genus Acmella and may be responsible for much of its biological activity due to the presence of lipophilic Nalkylamines. 11 The primary alkamide in the aerial sections, spilanthol (affinin), is what gives the plant its medicinal properties, such as anaesthetic 12 and anti-inflammatory effects, 5 immunological stimulation, 13 and saliva-secretion induction. We have chosen the methanol extract of Acmella oleracea leaves to examine the antioxidant, cytotoxic, thrombolytic, and antibacterial contents.…”

Section: Introductionmentioning

confidence: 99%

In vitro pharmacological activities of methanol extract of Acmella oleracea leaves: A variety grown in Dhaka, Bangladesh

Alam

Akash²

2023

IJMR

Self Cite

View full text Add to dashboard Cite

is known as toothache plant belongs to the family of Asteraceae. It is treated as a medicinal remedy like tuberculosis, illness, cough, rheumatism, and illness. This study was concentrated on the antioxidant, cytotoxic, antimicrobial & thrombolytic activities of methanol extract of leaves using in vitro model. The antioxidant activity was estimated as trolox equivalent antioxidant capacity utilizing the DPPH and reducing power tests. The plant extract was tested for its cytotoxic action using a brine shrimp lethality bioassay, thrombolytic activity using clot disruption, and antibacterial activity using a disc diffusion assay technique against four distinct gram-positive also gram-negative bacteria. ICvalue of standard ascorbic acid for DPPH was 7.8µg/ml and the IC50 of the methanol extract of leaves was 198.34µg/ml that was moderate effect at all compare with ascorbic acid. Thrombolytic assay of Streptokinase as a positive control showed 88.49% where the extract shows 18.69% lytic activity shows the assay. In this study, the sample of LC results of cytotoxicity assay was 1.431 µg/mL which can be treated as less activity. Moreover, the extracts showed low to moderate antibacterial activity against both gram-negative and gram-positive bacterial stains (zone of inhibition-10-26 mm). Vibrio Mimicus bacteria stains exhibited the highest level of activity, with a range of 23 for the diameter of the growth inhibition zone. The current review shows leaf extracts of may be used as a source of antioxidant and thrombolytic activity, as well as a significant source of antibacterial and anticancer substances. Further research is required to evaluate in-vivo the pharmacological activity of leaves in order to identify the essential metabolites and potential mechanisms.

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Pharmacological insight of rutin as a potential candidate against peptic ulcer

Akash,

Tabassum,

Aditee

et al. 2024

Biomedicine & Pharmacotherapy

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Cross-sectional Survey on Online Learning during COVID-19 Pandemic in Bangladesh

Cited by 3 publications

References 28 publications

In Vitro Pharmacological Activities of Methanol Extract of <em>Acmella oleracea</em> Leaves: A Variety Grown in Dhaka, Bangladesh

In Vitro Pharmacological Activities of Methanol Extract of <em>Acmella oleracea</em> Leaves: A Variety Grown in Dhaka, Bangladesh

In vitro pharmacological activities of methanol extract of Acmella oleracea leaves: A variety grown in Dhaka, Bangladesh

Pharmacological insight of rutin as a potential candidate against peptic ulcer

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