Cross-sectional study: Relationship between serum trace elements and hypertension

Zhang, Zhengduo; Zhao, Shuyong; Wu, Hong; Wen, Qin; Zhang, Tianran; Wang, Yuxin; Tang, Yanjin; Qi, Shaojun; Cao, Yiyao; Gao, Xibao

doi:10.1016/j.jtemb.2021.126893

Cited by 24 publications

(20 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In several of the biomarkers studied, we found statistically significant differences between the sexes, but the most relevant were the sex differences in plasma levels of Zn and Cu. These findings are consistent with previous studies [ 121 , 126 , 138 , 139 , 140 , 141 ]. Regarding urinary concentrations by sex, in our study, we observed that urinary excretion of Zn, Cu, and Se is higher in men.…”

Section: Discussionsupporting

confidence: 94%

“…However, the information available in the literature on this subject is contradictory. Some authors reported increases in Zn with age [ 138 ], while others report decreases [ 121 , 140 , 141 ]. In the case of Cu, some authors report increases with age [ 140 , 141 ], similar to Se [ 126 , 138 , 139 , 140 ]; however, [ 144 ] found very low Se levels in very elderly people.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors reported increases in Zn with age [ 138 ], while others report decreases [ 121 , 140 , 141 ]. In the case of Cu, some authors report increases with age [ 140 , 141 ], similar to Se [ 126 , 138 , 139 , 140 ]; however, [ 144 ] found very low Se levels in very elderly people. In the case of plasma Mn, our findings agree with those of some researchers [ 124 , 140 ], whereas other authors found increases with age [ 144 , 145 ] or no changes [ 126 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the case of Cu, some authors report increases with age [ 140 , 141 ], similar to Se [ 126 , 138 , 139 , 140 ]; however, [ 144 ] found very low Se levels in very elderly people. In the case of plasma Mn, our findings agree with those of some researchers [ 124 , 140 ], whereas other authors found increases with age [ 144 , 145 ] or no changes [ 126 ]. Regarding changes in urinary content of the trace elements with age, in our case it was found that Zn, Cu, and Se decreased with age, with no significant variations for Mn.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population

et al. 2022

View full text Add to dashboard Cite

Trace elements are micronutrients that are required in very small quantities through diet but are crucial for the prevention of acute and chronic diseases. Despite the fact that initial studies demonstrated inverse associations between some of the most important essential trace elements (Zn, Cu, Se, and Mn) and cardiovascular disease, several recent studies have reported a direct association with cardiovascular risk factors due to the fact that these elements can act as both antioxidants and pro-oxidants, depending on several factors. This study aims to investigate the association between plasma and urine concentrations of trace elements and cardiovascular risk factors in a general population from the Mediterranean region, including 484 men and women aged 18–80 years and considering trace elements individually and as joint exposure. Zn, Cu, Se, and Mn were determined in plasma and urine using an inductively coupled plasma mass spectrometer (ICP-MS). Single and combined analysis of trace elements with plasma lipid, blood pressure, diabetes, and anthropometric variables was undertaken. Principal component analysis, quantile-based g-computation, and calculation of trace element risk scores (TERS) were used for the combined analyses. Models were adjusted for covariates. In single trace element models, we found statistically significant associations between plasma Se and increased total cholesterol and systolic blood pressure; plasma Cu and increased triglycerides and body mass index; and urine Zn and increased glucose. Moreover, in the joint exposure analysis using quantile g-computation and TERS, the combined plasma levels of Zn, Cu, Se (directly), and Mn (inversely) were strongly associated with hypercholesterolemia (OR: 2.03; 95%CI: 1.37–2.99; p < 0.001 per quartile increase in the g-computation approach). The analysis of urine mixtures revealed a significant relationship with both fasting glucose and diabetes (OR: 1.91; 95%CI: 1.01–3.04; p = 0.046). In conclusion, in this Mediterranean population, the combined effect of higher plasma trace element levels (primarily Se, Cu, and Zn) was directly associated with elevated plasma lipids, whereas the mixture effect in urine was primarily associated with plasma glucose. Both parameters are relevant cardiovascular risk factors, and increased trace element exposures should be considered with caution.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population

et al. 2022

View full text Add to dashboard Cite

show abstract

“…šź žźƇƂƆƂ ƅƟƌſƊźƌƍƊƂ, ƁƇƂƀſƇƂƃ żƆƟƋƌ ƏƊƈƆƍ ż ƈƊŽźƇƟƁƆƟ ƉƊƂƁżƈžƂƌƖ žƈ ƊƈƁżƂƌƄƍ ƟƇƋƍƅƟƇƈƊſƁƂƋƌſƇƌƇƈƋƌƟ ƌź ƉƈƊƍƒſƇƇƙ ƈŻƆƟƇƍ ƅƟƉƟžƟż, ƍƇźƋƅƟžƈƄ ƑƈŽƈ ƆƈƀƍƌƖ ƊƈƁżƂżźƌƂ-Ƌƙ ƌźƄƟ ƁźƏżƈƊƘżźƇƇƙ, ƙƄ ƐƍƄƊƈżƂƃ žƟźŻſƌ őő ƌƂƉƍ, ƈƀƂƊƟƇƇƙ [12,14]. ũƈƄźƁźƇź ƄƈƊſƅƙƐƟƙ žſƎƟƐƂƌƍ ƏƊƈƆƍ Ɓ ƉƟžżƂƓſƇƇƙƆ ƄźƊžƟƈżźƋƄƍ-ƅƙƊƇƂƏ ƊƂƁƂƄƟż [21,50]…”

unclassified

The biological role of chromium and the impact of changes in its content on the course of obesity and hypertension in children (literature review, own research)

Marushko¹,

Kostynska²,

Hyshchak³

et al. 2022

MPU

View full text Add to dashboard Cite

The study of the role of certain microelements deficiency in the human body has not lost its relevance for decades. One of these microelements is chromium. Given its ability to reduce oxidative stress and chronic inflammation in the human body, much attention is being paid to studying the role of chromium in the treatment of obesity and hypertension. A number of scientists in their studies have shown a positive effect of chromium supplementation in these diseases. However, a large number of unexplored questions remain. In particular, most of the studies are devoted to the study of isolated diseases, while many patients usually have a comorbidity of several diseases. Also, the study of the role of this microelement in children remains without the attention of scientists. Most scientists note the need for further research in this direction. Purpose - to summarize the literature data and the results of our own studies of the biological role of chromium and the impact of changes in its content on the course of obesity and hypertension in children. Results and conclusions. Today, the role of chromium in the treatment and prevention of obesity and hypertension continues to be studied. According to literature sources, with a decrease in the level of chromium in the blood plasma of patients, obesity and hypertension are statistically significantly more often recorded. In systematic reviews chromium supplementation has been shown to reduce body weight and systolic and diastolic blood pressure in patients with obesity and hypertension. As a result of the study, it was found that the level of chromium in the hair of school-age children with hypertension in combination with obesity is statistically significantly (p<0.01) lower than in healthy peers. No conflict of interests was declared by the authors. Key words: chromium, microelements, obesity, hypertension, comorbidity, children.

show abstract

Associations of essential metals with the risk of aortic arch calcification: a cross‐sectional study in a mid‐aged and older population of Shenzhen, China

Mo,

Yin,

Wang

et al. 2024

MedComm

View full text Add to dashboard Cite

Vascular calcification is a strong predictor of cardiovascular events. Essential metals play critical roles in maintaining human health. However, the association of essential metal levels with risk of aortic arch calcification (AoAC) remains unclear. We measured the plasma concentrations of nine essential metals in a cross‐sectional population and evaluated their individual and combined effects on AoAC risk using multiple statistical methods. We also explored the mediating role of fasting glucose. In the logistic regression model, higher quartiles of magnesium and copper were associated with the decreased AoAC risk, while higher quartile of manganese was associated with higher AoAC risk. The least absolute shrinkage and selection operator penalized regression analysis identified magnesium, manganese, calcium, cobalt, and copper as key metals associated with AoAC risk. The weighted quantile sum regression suggested a combined effect of metal mixture. A linear and positive dose–response relationship was found between manganese and AoAC in males. Moreover, blood glucose might mediate a proportion of 9.38% of the association between manganese exposure and AoAC risk. In summary, five essential metal levels were associated with AoAC and showed combined effect. Fasting glucose might play a significant role in mediating manganese exposure‐associated AoAC risk.

show abstract

Cross-sectional study: Relationship between serum trace elements and hypertension

Cited by 24 publications

References 53 publications

Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population

Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population

The biological role of chromium and the impact of changes in its content on the course of obesity and hypertension in children (literature review, own research)

Associations of essential metals with the risk of aortic arch calcification: a cross‐sectional study in a mid‐aged and older population of Shenzhen, China

Contact Info

Product

Resources

About