Cross-sectional study on sex differences in chronic pain patients using the DATAPAIN cohort

Waardenburg, Sophie; Meij, Nelleke de; Brouwer, Brigitte A.; Zundert, Jan Van; Kuijk, Sander M. J. van

doi:10.1136/rapm-2020-102385

Cited by 5 publications

(7 citation statements)

References 6 publications

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“…Furthermore, a patient characteristic that may play a role as well is age. We observed on the cross‐sectional level in our tertiary pain population patients of older age have a lower average pain intensity at presentation 3 . Yet, a longitudinal study on birth cohorts indicate that there is a positive relationship between age and pain intensity within patients over time 18 .…”

Section: Discussionmentioning

confidence: 58%

“…Yet, a longitudinal study on birth cohorts indicate that there is a positive relationship between age and pain intensity within patients over time 18 . Socio‐demographic variables that have a negative association with pain are education, employment, and wealth 3,18 . Yet, the question remains if these factors have influence on the outcome of the PGIC and are recommended to be further analyzed in future studies.…”

Section: Discussionmentioning

confidence: 99%

“… 1 Literature indicates a higher prevalence and average of pain intensity in women when compared to men. 2 , 3 Also, women seem to report greater functional limitations for the same pain intensity. 4 Yet, it is rather unclear whether differences in meaningfulness of changes in pain are existent between sexes.…”

Section: Introductionmentioning

confidence: 98%

“…Due to the highly subjective nature of pain, the meaningfulness of changes in pain is often difficult to interpret 1 . Literature indicates a higher prevalence and average of pain intensity in women when compared to men 2,3 . Also, women seem to report greater functional limitations for the same pain intensity 4 .…”

Section: Introductionmentioning

confidence: 99%

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Clinical important improvement of chronic pain patients in randomized controlled trials and the DATAPAIN cohort

et al. 2021

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Background Change on the Numeric Rating Scale (NRS) is based on subjective pain experience, hampering the establishment of clinically important improvement. An anchor‐based method, the Patients’ Global Impression of Change (PGIC), is often added to determine whether a patient has improved. A two‐point change on the NRS has been shown to be equivalent to a moderate clinically important improvement in randomized controlled trials (RCT’s) on medication effects. We contemplated whether these findings could be reproduced in cohort and data and in non‐drug interventional RCT’s. Methods The NRS change was quantified by subtracting the NRS of baseline from the NRS at 6‐month follow‐up. Categorization of success/nonsuccess was applied on the PGIC, and their average NRS raw changes were calculated. The Spearman correlation coefficient quantified the overall relationship, while the discriminative ability was explored through the receiver operating characteristic curve. Data were stratified on design, sex, and pain intensity at baseline. Besides, the cohort evaluated treatment status at follow‐up. Results The records of 1661 patients were examined. Overall, the observed NRS change needed for moderate clinically important improvement was larger than the average two points. Yet, the changes in the cohort were smaller compared with the RCT’s. Moreover, it modified with pain intensity at baseline and treatment statuses indicated differences in mean clinical importance of −4.15 (2.70) when finalized at 6 months and −2.16 (2.48) when treatment was ongoing. Conclusion The moderate clinically important improvement varied substantially, representing heterogeneity in pain relief and its relation to treatment success in chronic pain patients.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Clinical important improvement of chronic pain patients in randomized controlled trials and the DATAPAIN cohort

et al. 2021

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“…Some workers reported that women in the general population have a higher prevalence of headache, musculoskeletal pain, arthritis, irritable bowel syndrome and neuropathic pain than men [31]. The discrepancies in the above findings may be partly explained by different socio-cultural characteristics of various patient cohorts rather than by biological sex characteristics alone [34].…”

Section: Discussionmentioning

confidence: 95%

Gender Differences in Pain Subtypes among Patients with Parkinson's Disease

Gao¹,

Yang²,

Cai³

et al. 2022

J. Integr. Neurosci.

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Background: To determine the influence of gender on the different pain subtypes experienced by patients with Parkinson's disease (PD). Methods: Two hundred patients with PD were recruited for this research. Demographic features for all patients were recorded, as well as clinical data on age, disease duration, levodopa equivalent daily dose (LEDD), and scores for Unified Parkinson's Disease Rating Scale-III (UPDRS III), Hoehn-Yahr Scale (H&Y), King's Parkinson's disease Pain Scale (KPPS), Pittsburgh Sleep Quality Index (PSQI), Mini-mental State Examination (MMSE), activities of daily living scale (ADL), Hamilton Depression Rating Scale (HAMD), and Hamilton Anxiety Rating Scale (HAMA) scales. Results: Male and female patients showed no significant differences in terms of age, disease duration, LEDD, H&Y stage, and UPDRS III, HAMD, HAMA, PSQI and ADL scores. Women showed significantly lower MMSE than men, but their KPPS scores were higher (both p < 0.05). Female also showed significantly higher scores for chronic, fluctuation-related pain and oro-facial pain and more discoloration;edema/swelling than males (p < 0.05). Conclusions: Female gender was associated with pain in PD patients, with stronger associations for certain subtypes of PD-related pain.

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Sex and gender differences in pain

Osborne

Davis

2022

International Review of Neurobiology

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Cross-sectional study on sex differences in chronic pain patients using the DATAPAIN cohort

Cited by 5 publications

References 6 publications

Clinical important improvement of chronic pain patients in randomized controlled trials and the DATAPAIN cohort

Clinical important improvement of chronic pain patients in randomized controlled trials and the DATAPAIN cohort

Gender Differences in Pain Subtypes among Patients with Parkinson's Disease

Sex and gender differences in pain

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