Cross-sectional study of the prevalence and clinical features of osteoarthritis in 100 cats

Slingerland, L.I.; Hazewinkel, H.A.W.; Meij, Björn P.; Picavet, Ph.; Voorhout, George

doi:10.1016/j.tvjl.2009.12.014

Cited by 126 publications

(160 citation statements)

References 18 publications

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“…In contrast, the cats with DJD were necessarily more impaired, as these were cats selected for inclusion in clinical trials, with a relatively high bar set for entry. While these groups of cats were not matched for age, and age is clearly important in physical activity level, it is difficult to find older cats without radiographic DJD (and associated pain) as prevalence of radiographic DJD in cats has been estimated at 60–92% of cats, with increased prevalence associated with age [63, 64]. The current study required cats that were classified as Normal to have minimal to no radiographic evidence of DJD.…”

Section: Discussionmentioning

confidence: 99%

The Use of Functional Data Analysis to Evaluate Activity in a Spontaneous Model of Degenerative Joint Disease Associated Pain in Cats

et al. 2017

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Introduction and objectivesAccelerometry is used as an objective measure of physical activity in humans and veterinary species. In cats, one important use of accelerometry is in the study of therapeutics designed to treat degenerative joint disease (DJD) associated pain, where it serves as the most widely applied objective outcome measure. These analyses have commonly used summary measures, calculating the mean activity per-minute over days and comparing between treatment periods. While this technique has been effective, information about the pattern of activity in cats is lost. In this study, functional data analysis was applied to activity data from client-owned cats with (n = 83) and without (n = 15) DJD. Functional data analysis retains information about the pattern of activity over the 24-hour day, providing insight into activity over time. We hypothesized that 1) cats without DJD would have higher activity counts and intensity of activity than cats with DJD; 2) that activity counts and intensity of activity in cats with DJD would be inversely correlated with total radiographic DJD burden and total orthopedic pain score; and 3) that activity counts and intensity would have a different pattern on weekends versus weekdays.Results and conclusionsResults showed marked inter-cat variability in activity. Cats exhibited a bimodal pattern of activity with a sharp peak in the morning and broader peak in the evening. Results further showed that this pattern was different on weekends than weekdays, with the morning peak being shifted to the right (later). Cats with DJD showed different patterns of activity from cats without DJD, though activity and intensity were not always lower; instead both the peaks and troughs of activity were less extreme than those of the cats without DJD. Functional data analysis provides insight into the pattern of activity in cats, and an alternative method for analyzing accelerometry data that incorporates fluctuations in activity across the day.

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Section: Discussionmentioning

confidence: 99%

The Use of Functional Data Analysis to Evaluate Activity in a Spontaneous Model of Degenerative Joint Disease Associated Pain in Cats

et al. 2017

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“…The progressive deterioration of one or more components of the joint is associated with pain, inflammation, peripheral and/or central sensitisation and decreased mobility, which ultimately impact activity and quality of life [1–5]. Radiographic evidence of OA is reported in up to 61% of cats older than six years of age [6] and in up to 90% of cats older than 12 years of age [7]. Similarly, the incidence of OA increases with age and is the leading cause of disability due to pain in both dogs [8] and humans [9].…”

Section: Introductionmentioning

confidence: 99%

Analgesic efficacy of tramadol in cats with naturally occurring osteoarthritis

et al. 2017

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ObjectivesThis study aimed to (1) compare outcome assessments in normal and osteoarthritic cats and (2) evaluate the analgesic efficacy of tramadol in feline osteoarthritis (OA), in a prospective, randomised, blinded, placebo-controlled, crossover design.MethodsTwenty cats were included after clinical examination, blood work and full body radiographs were performed. In Phase 1, outcome assessments aimed to differentiate normal (n = 5; i.e. exempt of any radiographic and clinical sign of OA) from OA (n = 15) cats. In Phase 2, OA cats were treated twice daily with a placebo (PG: cornstarch 15 mg) or tramadol (TG: 3 mg/kg) orally for 19 days, with a 3-month washout period between treatments. Evaluations were performed in normal and OA cats at baseline and consisted of: 1) peak vertical force (PVF) after staircase exercise; 2) telemetered night-time motor activity (NMA); and 3) response to mechanical temporal summation (RMTS). After treatment, PVF, NMA and RMTS evaluations were repeated in OA cats. Data were analysed with mixed model methods with an alpha-threshold of 5%.ResultsPhase 1: 1) PVF (% of body weight; mean ± SD) was higher in normal (59 ± 10.5) than in OA cats (50.6 ± 5.7) (p = 0.005); 2) NMA (no unit) was not different between groups; 3) RMTS (number of stimuli; median (range)) was higher in normal [29.5 (23.5–30)] than in OA cats [14 (8.5–28)] (p < 0.0001). Phase 2: PVF, NMA and RMTS presented a treatment effect (p = 0.024, p = 0.008 and p = 0.018, respectively). No clinically important adverse-effects were observed.ConclusionOutcome assessments such as kinetics (PVF) and evaluation of central sensitisation (RMTS) are discriminant of OA status. Mobility measured by NMA was not discriminant of OA status, however it increased in OA cats with tramadol treatment. Nociceptive hypersensitivity quantified by RMTS was evident in OA cats and was responsive to tramadol treatment.

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“…In cats, osteoarthritis (OA) develops with aging and causes significant chronic pain expressed as gait abnormalities, decreased activity and various behavioral changes (Bennett and Morton, 2009;Lascelles et al, 2010;Slingerland et al, 2011;Benito et al, 2012;Bennett et al, 2012;Klinck et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

[18F]-fluorodeoxyglucose positron emission tomography of the cat brain: A feasibility study to investigate osteoarthritis-associated pain

Guillot

Chartrand

Chav

et al. 2015

The Veterinary Journal

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Cross-sectional study of the prevalence and clinical features of osteoarthritis in 100 cats

Cited by 126 publications

References 18 publications

The Use of Functional Data Analysis to Evaluate Activity in a Spontaneous Model of Degenerative Joint Disease Associated Pain in Cats

The Use of Functional Data Analysis to Evaluate Activity in a Spontaneous Model of Degenerative Joint Disease Associated Pain in Cats

Analgesic efficacy of tramadol in cats with naturally occurring osteoarthritis

[18F]-fluorodeoxyglucose positron emission tomography of the cat brain: A feasibility study to investigate osteoarthritis-associated pain

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