Cross-sectional study of muscle strength and bone mineral density in a population of 106 women between the ages of 44 and 87 years: relationship with age and menopause

Calmels, P.; Vico, Laurence; Alexandre, Christian; Minaire, P

doi:10.1007/bf00361547

Cited by 57 publications

(37 citation statements)

References 40 publications

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“…Muscle strength in lower limbs declines markedly after 60 y of age (15). In a 10-y prospective population-based study, the patterns of loss in grip-strength scores from the ages of 50, 60, and 70 y were consistent, whereas balance and gait performance were significantly impaired from 60 and 70 y old onwards, respectively (16).…”

mentioning

confidence: 94%

Effects of Nutritional Supplementation with Milk Fat Globule Membrane on Physical and Muscle Function in Healthy Adults Aged 60 and Over with Semiweekly Light Exercise: A Randomized Double-Blind, Placebo-Controlled Pilot Trial

Minegishi

Ota

Soga

et al. 2016

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThis study aimed to demonstrate the beneficial effects of nutritional supplementation with dietary milk fat globule membrane (MFGM) on physical performance and skeletal muscle function in healthy adults aged 60 and over with semiweekly light exercise. The study was designed as a randomized double-blind controlled trial. Twenty-two Japanese participants (10 men, 12 women) aged 60-73 y were assigned to one of two groups (11 [5 men, 6 women] in each). One group received MFGM tablets (1 g MFGM/d), and the other received placebo tablets daily for 10 wk. Both groups participated in a twice-weekly light exercise program. Physical function tests and surface electromyography (EMG) were conducted at the baseline and after 5 and 10 wk. Chair stand time significantly shortened in both groups after 10 wk compared with that at the baseline. The average time shortened more considerably in the MFGM group than in the placebo group, although the change was not statistically significant. Both knee extension strength and the cross-sectional area of the quadriceps muscles significantly increased from baseline in the MFGM group but not in the placebo group. Surface EMG showed that muscle fiber conduction velocity increased significantly after 10 wk from the baseline only in the MFGM group. The increase from the baseline was significantly greater in the MFGM group than in the placebo group. Daily supplementation with MFGM increased motor unit action potential conduction and improved muscle strength and physical performance in healthy Japanese adults aged 60 y and over paired with semiweekly light exercise.

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confidence: 94%

Effects of Nutritional Supplementation with Milk Fat Globule Membrane on Physical and Muscle Function in Healthy Adults Aged 60 and Over with Semiweekly Light Exercise: A Randomized Double-Blind, Placebo-Controlled Pilot Trial

Minegishi

Ota

Soga

et al. 2016

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…(6,7) However, given the fact that 39% of older adults (age ≥54 years) in the United States are obese and over 65% meet criteria for being either overweight or obese,(8) there is a need to examine the relationship between BMD and knee extensor strength in a population which includes obese adults.…”

Section: Introductionmentioning

confidence: 99%

Muscle Mass Is More Strongly Related to Hip Bone Mineral Density Than Is Quadriceps Strength or Lower Activity Level in Adults Over Age 50Year

Segal

Torner

Yang

et al. 2008

Journal of Clinical Densitometry

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This cross-sectional study examined whether reduced hip bone mineral density (BMD) is better explained by isokinetic knee extensor strength (KES), lower limb lean body mass (L-LBM), or activity level (PASE). Through population-based recruitment, 1543 adults without knee osteoarthritis were recruited. For men and women respectively, means ± SD were: Age 60.8±8.0 and 61.1±7.9 years; BMI 29.6±4.6 and 29.1±5.4 kg/m2; hip BMD 1.025±0.138 and 0.895±0.128 g/cm 2 ; KES 124.9 ±41 and 72.7±22.9 N•m; L-LBM 10.3±1.5 and 7.0±1.2 kg; and PASE 206.4±99.7 and 163.8±77.0. The relationship between BMD and KES in men (r=.21, p<.002) and women (r=.23, p<.001) was significant before adjustment. However, this association was no longer significant after controlling for L-LBM. Even after controlling for age, race, and sex, the association between BMD and KES was better explained by L-LBM (partial R 2 =.14, p<.001) than by PASE (partial R 2 =.00). Allometric scaling of KES to body size attenuated the association of BMD with KES (Std Beta=.03). The significant association between BMD and L-LBM (Std Beta=.36) remained stronger than that between BMD and weight (Std Beta=.21). Therefore, muscle mass accounted for a greater proportion of the variance in hip BMD than KES or activity level and explained a significant proportion of the association between weight and BMD.

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“…There are clear gender specific differences in the prevalence of sarcopenia. In women, deterioration in muscle performance has been observed as early as during perimenopause, 4 making them more vulnerable to sarcopenia than agematched men. 5,6 This indicates that the female sex hormones, estrogens, might be involved in the early developmental steps of sarcopenia.…”

Section: Introductionmentioning

confidence: 99%

Muscular Transcriptome in Postmenopausal Women With or Without Hormone Replacement

Pöllänen

Ronkainen

Suominen

et al. 2007

Rejuvenation Research

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The loss of muscle mass and strength with aging is well characterized, but our knowledge of the molecular mechanisms underlying the development of sarcopenia remains incomplete. Although menopause is often accompanied with first signs of age-associated changes in muscle structure and function, the effects of hormone replacement therapy (HRT) or menopause-related decline in estrogen production in the muscles of postmenopausal women is not well understood.Furthermore the knowledge of the global transcriptional changes that take place in skeletal muscle in relation to estrogen status has thus far been completely lacking. We used a randomized double-blinded study design together with an explorative microarray experiment to characterize possible effects of continuous, combined HRT and estrogen deprivation on the skeletal muscle of fifteen women. Here, we report the differential response of both GO-annotated biological processes and some individual genes responding differentially to the use or non-use of HRT. Our results revealed transcription level changes in, e.g., muscle protein and energy metabolism. In particular, the ubiquitine-proteosome system was found to be effected at several levels. HRT seemed to partially counteract the postmenopause-related transcriptional changes. Our results suggest that during the early postmenopausal years, when there is no counteracting medication available, muscle transcriptome changes notably, whereas HRT appears to slow-down this phenomenon and could therefore aid in maintaining proper muscle mass and function after menopause.3

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Cross-sectional study of muscle strength and bone mineral density in a population of 106 women between the ages of 44 and 87 years: relationship with age and menopause

Cited by 57 publications

References 40 publications

Effects of Nutritional Supplementation with Milk Fat Globule Membrane on Physical and Muscle Function in Healthy Adults Aged 60 and Over with Semiweekly Light Exercise: A Randomized Double-Blind, Placebo-Controlled Pilot Trial

Effects of Nutritional Supplementation with Milk Fat Globule Membrane on Physical and Muscle Function in Healthy Adults Aged 60 and Over with Semiweekly Light Exercise: A Randomized Double-Blind, Placebo-Controlled Pilot Trial

Muscle Mass Is More Strongly Related to Hip Bone Mineral Density Than Is Quadriceps Strength or Lower Activity Level in Adults Over Age 50Year

Muscular Transcriptome in Postmenopausal Women With or Without Hormone Replacement

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