Cross-sectional Study of Glutamate in the Anterior Cingulate and Hippocampus in Schizophrenia

Gallinat, Jürgen; McMahon, Kibby; Kühn, Simone; Schubert, Florian; Schaefer, Martin

doi:10.1093/schbul/sbv124

Cited by 42 publications

(37 citation statements)

References 68 publications

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“…Higher frontal Glx/Cr levels may predict poorer antipsychotic medication response(23). In medicated SCZ patients, glutamate is decreased(24) or unchanged(15) in ACC, decreased in PFC(25), and possibly decreased in hippocampus(24,26). Glx is also reduced in ACC(27) and mPFC of chronic patients, but not EC-SCZ or ultra-high-risk (UHR-SCZ) patients(28).…”

Section: Magnetic Resonance Spectroscopymentioning

confidence: 99%

Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders

Foss‐Feig

Adkinson

et al. 2017

Biological Psychiatry

235

183

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Recent theoretical accounts have proposed excitation (E) and inhibition (I) imbalance as a possible mechanistic, network-level hypothesis underlying neural and behavioral dysfunction across neurodevelopmental disorders, particularly autism spectrum disorder (ASD) and schizophrenia (SCZ). These two disorders share some overlap in their clinical presentation as well as convergence in their underlying genes and neurobiology. However, there are also clear points of dissociation in terms of phenotypes and putatively affected neural circuitry. Here we highlight emerging work from the clinical neuroscience literature examining neural correlates of E/I imbalance across children and adults with ASD and adults with both chronic and early-course SCZ. We discuss findings from diverse neuroimaging studies across distinct modalities, conducted with EEG, MEG, 1H-MRS, and fMRI, including effects observed both during task and at rest. Throughout this review we discuss points of convergence and divergence in the ASD and SCZ literature, with a focus on disruptions in neural E/I balance. We also consider these findings in relation to predictions generated by theoretical neuroscience, particularly computational models predicting E/I imbalance across disorders. Finally, we discuss how human non-invasive neuroimaging can benefit from pharmacological challenge studies to reveal mechanisms in ASD and SCZ. Collectively, we attempt to shed light on shared and divergent neuroimaging effects across disorders with the goal of informing future research examining the mechanisms underlying the E/I imbalance hypothesis across neurodevelopmental disorders. We posit that such translational efforts are vital to facilitate development of neurobiologically informed treatment strategies across neuropsychiatric conditions.

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Section: Magnetic Resonance Spectroscopymentioning

confidence: 99%

Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders

Foss‐Feig

Adkinson

et al. 2017

Biological Psychiatry

235

183

View full text Add to dashboard Cite

show abstract

“…Interestingly, alpha power was correlated with glutamate concentrations within the pACC, a factor that is known to be altered in schizophrenia (Gallinat, McMahon, Kühn, Schubert, & Schaefer, 2015;Mouchlianitis et al, 2015;Smesny et al, 2015)). A second study then showed that levels of spontaneous activity within the right temporoparietal junction (rTPJ) prior to stimulus onset, as measured with fMRI, determined whether an ambiguous sound would be experienced as the person's own name or not (Pengmin Qin et al, 2016).…”

Section: Abnormal Temporal and Spatial Structure In The Dmn And Ego Dmentioning

confidence: 99%

How do abnormalities in the brain’s spontaneous activity translate into symptoms in schizophrenia? From an overview of resting state activity findings to a proposed spatiotemporal psychopathology

Northoff

Duncan

2016

Progress in Neurobiology

124

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Schizophrenia is a complex neuropsychiatric disorder with a variety of symptoms that include sensorimotor, affective, cognitive, and social changes. The exact neuronal mechanisms underlying these symptoms remain unclear though. Neuroimaging has focused mainly on the brain's extrinsic activity, specifically task-evoked or stimulus-induced activity, as related to the sensorimotor, affective, cognitive, and social functions. Recently, the focus has shifted to the brain's spontaneous activity, otherwise known as its resting state activity. While various spatial and temporal abnormalities have been observed in spontaneous activity in schizophrenia, their meaning and significance for the different psychopathological symptoms in schizophrenia, are yet to be defined. The first aim in this paper is to provide an overview of recent findings concerning changes in the spatial (e.g., functional connectivity) and temporal (e.g., couplings between different frequency fluctuations) properties of spontaneous activity in schizophrenia. The second aim is to link these spatiotemporal changes to the various psychopathological symptoms of schizophrenia, with a specific focus on basic symptoms, formal thought disorder, and ego-disturbances. Based on the various findings described, we postulate that the spatiotemporal changes on the neuronal level of the brain's spontaneous activity transform into corresponding spatiotemporal changes on the psychological level which, in turn, leads to the different kinds of psychopathological symptoms. We consequently suggest a spatiotemporal rather than cognitive or sensory approach to the condition, amounting to what we describe as "Spatiotemporal Psychopathology".

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“…Therefore, there is an urgent need to improve pharmacotherapy of negative symptoms. Beside the dopaminergic system, dysfunctional glutamatergic neurotransmission has strongly been implicated in the etiology of schizophrenia, [1][2][3] particularly a hypofunction of the N-methyl-d-aspartate-receptor (NMDAR). 4 As NMDAR hypofunction is especially associated with negative symptoms, 5 the NMDAR is continuously discussed as being a promising target for the introduction of new medications.…”

Section: Introductionmentioning

confidence: 99%

Glutamatergic deficit and schizophrenia-like negative symptoms: new evidence from ketamine-induced mismatch negativity alterations in healthy male humans

Thiebes

Leicht

Ćurić

et al. 2017

JPN

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Cross-sectional Study of Glutamate in the Anterior Cingulate and Hippocampus in Schizophrenia

Cited by 42 publications

References 68 publications

Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders

Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders

How do abnormalities in the brain’s spontaneous activity translate into symptoms in schizophrenia? From an overview of resting state activity findings to a proposed spatiotemporal psychopathology

Glutamatergic deficit and schizophrenia-like negative symptoms: new evidence from ketamine-induced mismatch negativity alterations in healthy male humans

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