Cross-sectional study of genital carcinogenic HPV infections in Paramaribo, Suriname: prevalence and determinants in an ethnically diverse population of women in a pre-vaccination era

Geraets, D.T.; Grunberg, A; Helm, Jürgen; Loeff, Maarten F. Schim van der; Quint, Koen D.; Sabajo, Leslie O. A.; Vries, Henry J C de

doi:10.1136/sextrans-2013-051384

Cited by 15 publications

(13 citation statements)

References 28 publications

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“…Cervical HPV prevalence in this study is similar to that reported in high-risk populations ( 20 , 21 ) and higher than in other reports that used the same detection method, in Latin America (37 to 51%) ( 20 , 22 ), Europe (<20%) ( 23 ), and Japan (<20%) ( 24 ). This disparity in prevalence may be due to the high prevalence of anemia and intestinal helminthes, which may reduce HPV clearance ( 25 ), degree of isolation from the global HPV pool, etc., while for industrialized countries, vaccination is significantly reducing HPV infection ( 26 , 27 ).…”

Section: Discussionsupporting

confidence: 86%

High Rate of Infection by Only Oncogenic Human Papillomavirus in Amerindians

Vargas-Robles

Magris²,

Morales³

et al. 2018

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The role of HPV type distribution on the disparity of cervical cancer (CC) incidence between human populations remains unknown. The incidence of CC in the Amazonas State of Venezuela is higher than the national average. In this study, we determined the diversity of known HPV types (the viral agent of CC) in Amerindian and mestizo women living in the Venezuelan Amazonas State. Understanding the ecological diversity of HPV in populations undergoing lifestyle transformations has important implication on public health measures for cervical cancer prevention.

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Section: Discussionsupporting

confidence: 86%

High Rate of Infection by Only Oncogenic Human Papillomavirus in Amerindians

Vargas-Robles

Magris²,

Morales³

et al. 2018

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“…Other methods maybe be less sensitive, consistent with the lower prevalences reported for Latin America and Caribbean region in high-grade squamous intraepithelial lesions (41–67%) ( Parkin et al, 2008 ). High HPV prevalence ranging from 30 to 50% have been reported for other high-risk Latin American countries, using the same genotyping method SPF 25 /LiPA 10 , including anal specimens in Costa Rica ( Castro et al, 2012 ), and vaginal specimens in Surinam ( Geraets et al, 2014 ), as well as for Nigeria ( Adebamowo et al, 2017 ), Turkey ( Barut et al, 2018 ), and Italy ( Carozzi et al, 2018 ). The very high prevalence found in our study may reflect the high-risk patients from the San Juan Municipality, known to have rising cervical cancer diagnoses ( Registro Central De Cáncer De Puerto Rico, 2017 ).…”

Section: Discussionmentioning

confidence: 85%

Cervicovaginal Fungi and Bacteria Associated With Cervical Intraepithelial Neoplasia and High-Risk Human Papillomavirus Infections in a Hispanic Population

et al. 2018

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The human cervicovaginal microbiota resides at an interface between the host and the environment and may affect susceptibility to disease. Puerto Rican women have high human papillomavirus (HPV) infection and cervical cancer rates. We hypothesized that the population structure of the cervicovaginal bacterial and fungal biota changed with cervical squamous intraepithelial lesions and HPV infections. DNA was extracted from cervix, introitus, and anal sites of 62 patients attending high-risk San Juan clinics. The 16S rRNA V4 region and ITS-2 fungal regions were amplified and sequenced using Illumina technology. HPV genotyping was determined by reverse hybridization with the HPV SPF10-LiPA25 kit. HPV prevalence was 84% of which ∼44% subjects were infected with high-risk HPV, ∼35% were co-infected with as many as 9 HPV types and ∼5% were infected with exclusively low-risk HPV types. HPV diversity did not change with cervical dysplasia. Cervical bacteria were more diverse in patients with CIN3 pre-cancerous lesions. We found enrichment of Atopobium vaginae and Gardnerella vaginalis in patients with CIN3 lesions. We found no significant bacterial biomarkers associated with HPV infections. Fungal diversity was significantly higher in cervical samples with high-risk HPV and introitus samples of patients with Atypical Squamous Cells of Undetermined Significance (ASCUS). Fungal biomarker signatures for vagina and cervix include Sporidiobolaceae and Sacharomyces for ASCUS, and Malassezia for high-risk HPV infections. Our combined data suggests that specific cervicovaginal bacterial and fungal populations are related to the host epithelial microenvironment, and could play roles in cervical dysplasia.

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“…The science of cytokines is still being worked out, and far from an intervention. But its potential importance in STI control is borne out when we consider the extraordinarily high burdens of STI still borne by many populations in the developing world, which are also reported this month by Abdool-Karim et al ,10 Lurie et al 11 from South Africa, and Geraets12 from Suriname.…”

mentioning

confidence: 81%