Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases

Imai, Kazue; Nakachi, Kei

doi:10.1136/bmj.310.6981.693

Cited by 375 publications

(231 citation statements)

References 28 publications

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“…Several observational studies have investigated the association between tea consumption and HDL‐C concentrations 24, 25, 26, 27, 28. The findings have been mixed.…”

Section: Discussionmentioning

confidence: 99%

“…The findings have been mixed. Some studies have reported no association between green or black tea and HDL‐C concentrations,26, 27, 28 whereas others have reported a significant positive association between tea consumption and HDL‐C concentration 24, 25. Of note, those observational studies were cross‐sectional study design, making it impossible to infer the temporal association between tea consumption and lipid profiles.…”

Section: Discussionmentioning

confidence: 99%

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Tea Consumption and Longitudinal Change in High‐Density Lipoprotein Cholesterol Concentration in Chinese Adults

Huang

et al. 2018

JAHA

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BackgroundThe relation between tea consumption and age‐related changes in high‐density lipoprotein cholesterol (HDL‐C) concentrations remains unclear, and longitudinal human data are limited. The aim of current study was to examine the relation between tea intake and longitudinal change in HDL‐C concentrations.Methods and ResultsBaseline (2006) tea consumption was assessed via a questionnaire, and plasma HDL‐C concentrations were measured in 2006, 2008, 2010, and 2012 among 80 182 individuals (49±12 years of age) who did not have cardiovascular diseases or cancer, or did not use cholesterol‐lowering agents both at baseline (2006) and during the follow‐up period (2006–2012). The associations between baseline tea consumption and rate of change in HDL‐C concentrations were examined using generalized estimating equation models. Tea consumption was inversely associated with a decreased rate of HDL‐C concentrations (P‐trend <0.0001) in the fully adjusted model. The adjusted mean difference in the HDL‐C decreased rate was 0.010 (95% confidence interval, 0.008, 0.012) mmol/L per year for tea consumers versus nonconsumers (never or less than once/month group). Interactions between tea consumption and age, sex, lifestyle scores, and metabolic syndrome (all P‐interaction <0.0001) were identified. The associations between greater tea consumption and slower decrease in HDL‐C concentrations were more pronounced in men, individuals aged 60 or older, individuals with a lower lifestyle score, and individuals with metabolic syndrome (all P‐trend <0.0001).ConclusionsTea consumption was associated with slower age‐related decreases in HDL‐C concentrations during 6 years of follow‐up.Clinical Trial Registration URL: http://www.chictr.org. Unique identifier: ChiCTR‐TNRC‐11001489.

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“…Several observational studies have investigated the association between tea consumption and HDL‐C concentrations 24, 25, 26, 27, 28. The findings have been mixed.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Tea Consumption and Longitudinal Change in High‐Density Lipoprotein Cholesterol Concentration in Chinese Adults

Huang

et al. 2018

JAHA

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“…As yet, it is unclear whether these secondary plant metabolites are important nutritional antioxidants as little is known about their bioavailability, mechanism of uptake and consequences of biotransformation by intestinal¯ora (Hollman et al, 1997). However, epidemiological studies have implied that intakes of some phenolics are inversely related to risk of coronary heart disease (Hertog et al, 1993;Imai & Nakachi, 1995;Knekt et al, 1996). In addition, consumption of phenolicrich beverages such as red wine and tea are reported to transiently increase the ability of plasma to resist oxidative loads (Whitehead et al, 1995;Sera®ni et al, 1996) suggesting that at least a proportion of the phenolics in these beverages could have a role as antioxidants in vivo.…”

Section: Introductionmentioning

confidence: 99%

The effect of whisky and wine consumption on total phenol content and antioxidant capacity of plasma from healthy volunteers

Duthie¹,

Pedersen

Gardner³

et al. 1998

Eur J Clin Nutr

171

107

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Objective: To assess whether consumption of 100 ml of whisky or red wine by healthy male subjects increased plasma total phenol content and antioxidant capacity. Design: A Latin square arrangement to eliminate ordering effects whereby, after an overnight fast, nine volunteers consumed 100 ml of red wine, malt whisky or unmatured`new make' spirit. Each volunteer participated on three occasions one week apart, consuming one of the beverages each time. Blood samples were obtained from the anticubital vein at intervals up to 4h after consumption of the beverages when a urine sample was also obtained. Results: Within 30 min of consumption of the wine and whisky, there was a similar and signi®cant increase in plasma total phenol content and antioxidant capacity as determined by the ferric reducing capacity of plasma (FRAP). No changes were observed following consumption of`new make' spirit. Conclusions: Consumption of phenolic-containing alcoholic beverages transiently raises total phenol concentration and enhances the antioxidant capacity of plasma. This is compatible with suggestions that moderate alcohol usage and increased antioxidant intake decrease the risk of coronary heart disease. Sponsorship: Funded by the Scottish Of®ce Agriculture, Environment and Fisheries Department (SOAEFD), the ERASMUS exchange program, the EC-Fair program and the Scotch Whisky Research Institute.

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“…More important, these results with traditional herbal medicine could open the door to a new frontier in the search for preventive agents of cancer and other lifestyle-related diseases. 20) …”

Section: Inhibition Of Tumor Promotion By Geraniinmentioning

confidence: 99%

New TNF-.ALPHA. Releasing Inhibitors, Geraniin and Corilagin, in Leaves of Acer nikoense, Megusurino-ki.

Okabe

Suganuma

Imayoshi

et al. 2001

Biological & Pharmaceutical Bulletin

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We have recently reported that inhibition of tumor necrosis factor-a (TNF-a) release is a useful method for screening of cancer preventive agents, 1) because TNF-a and other inflammatory cytokines stimulate tumor promotion and progression of initiated cells as well as premalignant cells. 2,3) Since TNFa and interleukin-1 (IL-1), as endogenous tumor promoters, activate nuclear factor kB (NF-kB), 4,5) inhibitors of NF-kB activation are also assumed to be cancer preventive agents. 6) However, in a practical sense, it is quantitatively easier to measure inhibition of TNF-a release from cells treated with a tumor promoter such as okadaic acid than inhibition of NFkB activation using a gel mobility shift assay. 7) Based on the study of green tea as cancer preventive agent in the United States 8) and as cancer preventive beverage in Japan, 9) we decided to take a closer look at Japanese herbal medicine for other likely cancer preventives. One classical Japanese herb, Geranium thunbergii SIEB. et ZUCC. (Gennoshoko in Japanese), is used as an antidiarrhetic 10) ; it contains geraniin, which has been intensively studied as a representative tannin. 11) And the bark of Acer nikoense MAXIM (Megusurino-ki in Japanese), which contains diarylheptanoids, is sold as a folk medicine for eye and liver diseases in Japan. 12) The Forestry Experiment Station of Saitama Prefecture succeeded in culturing young plants of A. nikoense collaborated with us on the scientific utilization of the plant. We received four water extracts-leaves, bark, small branches, and timber-from the Station and subjected them to inhibition of TNF-a release assay using BALB/3T3 cells treated with okadaic acid 13) : The leaves showed the strongest activity among the four extracts. Each extract was subjected to highperformance liquid chromatography (HPLC) with CAP-CELL PAK C18, and geraniin and corilagin were identified in the active leaf extract (Fig. 1).In The success of green tea as a cancer preventive is based on evidence that green tea contains tannins and antioxidants, does not show toxicity in humans and has long traditional use in Asia. In the light of this, herbal medicines are now also attracting attention as potential sources of cancer preventive agents. Using the inhibition of TNF-a a release assay, we studied Acer nikoense (Megusurino-ki in Japanese), one of the herbal medicines. The inhibitory activity of TNF-a a release was found in the leaf extract rather than the bark extract, and the main active constituents were identified as geraniin and corilagin, which are present in another Japanese traditional herb, Geranium thunbergii (Genno-shoko). The IC 50 values of TNF-a a release inhibition were 43 m mM for geraniin and 76 m mM for corilagin, whereas that for (؊)-epigallocatechin gallate (EGCG) was 26 m mM. Treatment with geraniin prior to application of okadaic acid, a tumor promoter on mouse skin initiated with 7,12-dimethylbenz(a)anthracene, reduced the percentage of tumor-bearing mice from 80.0 to 40.0% and the average numbers of tumor per mouse ...

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Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases

Cited by 375 publications

References 28 publications

Tea Consumption and Longitudinal Change in High‐Density Lipoprotein Cholesterol Concentration in Chinese Adults

Tea Consumption and Longitudinal Change in High‐Density Lipoprotein Cholesterol Concentration in Chinese Adults

The effect of whisky and wine consumption on total phenol content and antioxidant capacity of plasma from healthy volunteers

New TNF-.ALPHA. Releasing Inhibitors, Geraniin and Corilagin, in Leaves of Acer nikoense, Megusurino-ki.

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