Cross-sectional echocardiography. II. Analysis of mathematic models for quantifying volume of the formalin-fixed left ventricle.

Wyatt, H.L.; Heng, Ming K.; Meerbaum, Samuel; Guéret, Pascal; Hestenes, J. D.; Dula, E; Corday, E

doi:10.1161/01.cir.61.6.1119

Cited by 206 publications

(45 citation statements)

References 7 publications

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“…10 Left ventricular volume was calculated by the area-length method. 11 Ejection fraction was calculated as 100 ϫ (end-diastolic volume -endsystolic volume) Ϭend-diastolic volume. Left ventricular mass was calculated by the formula of Devereux and Reichek.…”

Section: Discussionmentioning

confidence: 99%

Adaptive mechanisms of left ventricular diastolic function to the physiologic load of pregnancy

Moran

Colan

Mauer

et al. 2002

Clinical Cardiology

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SummaryBackground: Pregnancy is associated with marked alteration in cardiovascular hemodynamics. Recent reports have characterized the effects on cardiac systolic function. Little has been written on the influences of loading conditions on Doppler measures of diastolic function during pregnancy.Hypothesis: Stage of pregnancy has an impact on Doppler indices of diastolic function independent of loading conditions, systolic function, and heart rate.Method: Thirty healthy women were prospectively evaluated by serial echocardiography and Doppler examinations at six time periods: 10-12, 18-20, 28-30, 36-38 weeks gestation, 2-4 and 12-14 weeks postpartum. The related effects on indices of diastolic function and its interaction with load, heart rate, mass, and systolic function were determined.Results: Compared with the nonpregnant state, early (E) velocity increased (0.7 ± 0.1-0.9 ± 0.1 m/s, p = 0.0001), peaking at 18 weeks and returning to normal levels during late pregnancy. Atrial phase (A) velocity peaked at 18 weeks (0.48 ± 0.12-0.60 ± 0.13 m/s, p = 0.0001), remaining high throughout the rest of pregnancy. Consequently, the E/A ratio fell significantly during late pregnancy, from 1.9 ± 0.4 to 1.4 ± 0.3 (p = 0.02). In addition, mean acceleration was significantly increased in early pregnancy with a peak at 18 weeks (7.4 ± 1.3 m/s 2 ), returning to nonpregnant level at term (5.7 ± 1.4 m/s 2 , p = 0.0001). Generalized estimating equation using multivariate regression analysis demonstrated that rising heart rate and stroke volume index had an independent effect on A velocity, and that contractility and preload had an independent effect

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Section: Discussionmentioning

confidence: 99%

Adaptive mechanisms of left ventricular diastolic function to the physiologic load of pregnancy

Moran

Colan

Mauer

et al. 2002

Clinical Cardiology

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“…LV end-diastolic diameter (LVEDD), LV end-systolic diameter, and posterior wall thickness were measured. LVEF was calculated by measurement of LV end-systolic and end-diastolic volumes using the prolate ellipsoid geometric model (57). Endocardial velocity (Vendo) was calculated using TVI, which was acquired in the short-axis window at the level of the papillary muscles, at a rate of 483 frames/s (30,46,55,60).…”

Section: Methodsmentioning

confidence: 99%

The utility of cardiac biomarkers and echocardiography for the early detection of bevacizumab- and sunitinib-mediated cardiotoxicity

Bordun

Premecz

daSilva

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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DS. The utility of cardiac biomarkers and echocardiography for the early detection of bevacizumab-and sunitinib-mediated cardiotoxicity. Am J Physiol Heart Circ Physiol 309: H692-H701, 2015. First published June 19, 2015; doi:10.1152/ajpheart.00172.2015.-The recent introduction of novel anticancer therapies, including bevacizumab (BVZ) and sunitinib (SNT), is associated with an increased risk of cardiotoxicity. However, early identification of left ventricular (LV) systolic dysfunction may facilitate dose modification and avoid the development of advanced heart failure. Using a murine model of BVZ-and SNTmediated cardiotoxicity, we investigated whether cardiac biomarkers and/or tissue velocity imaging (TVI) using echocardiography can detect early changes in cardiac function, before a decrease in LV ejection fraction is identified. A total of 75 wild-type C57Bl/6 male mice were treated with either 0.9% saline, BVZ, or SNT. Serial monitoring of blood pressure, high-sensitivity troponin I, and echocardiographic indexes were performed over a 14-day study period, after which the mice were euthanized for histological and biochemical analyses. Mice treated with either BVZ or SNT developed systemic hypertension as early as day 7, which increased by day 14. Cardiac biomarkers, specifically high-sensitivity troponin I, were not predictive of early LV systolic dysfunction. Although conventional LV ejection fraction values decreased at day 13 in mice treated with either BVZ or SNT, TVI confirmed early LV systolic dysfunction at day 8. Histological and biochemical analysis demonstrated loss of cellular integrity, increased oxidative stress, and increased cardiac apoptosis in mice treated with BVZ or SNT therapy at day 14. In a murine model of BVZ-or SNT-mediated cardiomyopathy, noninvasive assessment by TVI detected early LV systolic dysfunction before alterations in conventional echocardiographic indexes.cardio-oncology; heart failure; cardiotoxicity; hypertension; bevacizumab; sunitinib; cardiac biomarkers; echocardiography; apoptosis NEW & NOTEWORTHYThe current basic science study evaluates the utility of cardiac biomarkers and echocardiography using tissue velocity imaging and strain rate imaging for the early detection of bevacizumab-and sunitinib-mediated cardiotoxicity.CARDIO-ONCOLOGY IS A NOVEL discipline that focuses on the prevention, diagnosis, and management of cancer patients who are at risk of developing cardiovascular complications as a result of their anticancer treatment. Despite the beneficial effects of chemotherapy agents in increasing overall survival of cancer patients, cardiotoxicity remains a serious complication of many systemic anticancer therapies (4,5,26,32,36,47,49,58). The treatment strategy for each patient is individualized, involving a combination of surgical intervention, radiation, chemotherapy, and novel targeted biological therapy.Two types of targeted therapies widely used for treating metastatic colorectal (CRC) and renal cell cancer (RCC), respectively, are the monoclonal antibody bev...

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“…The results are expressed in millimeters. The calculation of the end-diastolic and end-systolic volumes of the left ventricular cavity was performed according to the Simpson technique 11 . Two variables were used for assessing the left ventricular overall systolic function: a) shortening fraction (delta D); and b) ejection fraction.…”

Section: Methodsmentioning

confidence: 99%

Sensibilidade e especificidade do hormônio natriurético do tipo B para identificar doentes com insuficiência mitral grave sintomáticos e assintomáticos

Meneghelo¹,

Magalhães²,

Ramos³

et al. 2004

Arq. Bras. Cardiol.

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ObjectiveTo assess the sensitivity and specificity of B-type natriuretic peptide (BNP) for identifying symptomatic and asymptomatic patients with severe chronic mitral regurgitation followed up on an outpatient care basis. Methods A group of patients with mitral regurgitation underwent electrocardiography, chest teleradiography, venous blood withdrawal, and transthoracic echocardiography. Based on an analysis of the echocardiographic variables, 62 patients had mild and moderate mitral regurgitation (GI) and 34 had severe mitral regurgitation (GII). The discriminating capacity of the BNP for detecting patients with severe mitral regurgitation was assessed by use of ROC curves. ResultsThe patients' ages ranged from 15 to 63 (mean, 31.7) ConclusionThe BNP values capable of identifying asymptomatic and symptomatic patients with severe mitral regurgitation are lower than 100 pg/mL, which is considered for the diagnosis of heart failure. Key words mitral regurgitation, natriuretic peptides, BNPThe measurement of B-type natriuretic peptide (or brain natriuretic peptide, BNP) levels has been used for diagnosing congestive heart failure, especially when the symptoms and signs are discrete or mild, and in the presence of associated comorbidities, such as pulmonary disease or obesity 1 . The BNP levels have a positive correlation with left ventricular end-diastolic pressure and an inverse correlation with left ventricular function. These concentrations are considered to represent an independent evaluation of ventricular function, with no need for other more expensive tests 2 . The cutoff point of the BNP levels recommended for separating the population with heart failure from that without that syndrome is 100 pg/mL 3 . These initial findings suggest the possibility of expanding the application of BNP level measurement to other situations that gradually lead to left ventricular dysfunction, such as some valvular diseases and congenital heart diseases. The BNP levels in patients with mitral regurgitation are greater than those in controls. The study by Brookes et al 4 showed that 89% of the 22 patients with mitral regurgitation have more elevated BNP levels than healthy individuals do, 20.85 ± 16.9 versus 3.37 ± 0.9 pmol/L. Another study 5 with symptomatic and asymptomatic patients showed that the BNP levels increased according to the severity of mitral regurgitation and were greater in symptomatic patients. However, the case series of these reports are small, and the authors of both studies suggested additional investigation. The objective of the present study was to assess in a group of patients with chronic mitral regurgitation of different degrees, which is the BNP cutoff point capable of identifying the existence of severe mitral regurgitation with or without symptoms. MethodsThe study comprised patients from the valvular heart disease outpatient clinic of our institution diagnosed with chronic mitral regurgitation and who agreed to participate in the study. The diagnosis was based on physical examination due to the ...

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Cross-sectional echocardiography. II. Analysis of mathematic models for quantifying volume of the formalin-fixed left ventricle.

Cited by 206 publications

References 7 publications

Adaptive mechanisms of left ventricular diastolic function to the physiologic load of pregnancy

Adaptive mechanisms of left ventricular diastolic function to the physiologic load of pregnancy

The utility of cardiac biomarkers and echocardiography for the early detection of bevacizumab- and sunitinib-mediated cardiotoxicity

Sensibilidade e especificidade do hormônio natriurético do tipo B para identificar doentes com insuficiência mitral grave sintomáticos e assintomáticos

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