Cross-Sectional Distributions of Platelet-Sized Particles in Blood Flow through Microchannels

The in vitro inertial positions and viability of cells in suspension under different in vivo flow conditions

“…Previous computational and experimental work has found that at lower Re (see Table 1a), the entry length for rigid particles is smaller, therefore, it is believed that this channel length was sufficient in order to achieve fully developed radial migration 15,16,39 . Previous studies examining the migration length of deformable red blood cells have shown that in similarly-sized microchannels, a migration length of ≈20 mm is a sufficient length in order to achieve fully developed radial migration 38 . As cancer cells are considered to be less deformable than red blood cells, and the channel length is sufficient for the inertial migration of both rigid particles and deformable red blood cells, it is believed to be of adequate length to achieve the inertial migration of deformable cancer cells.…”

“…In order to assess the effects of cell deformability on equilibrium position, the equilibrium positions of rigid particles of 10.22 ± 0.13 μm and 27-32 μm diameter were also investigated. These equilibrium positions were examined at a distance of ≈20 cm from the channel inlet, resulting in a length to diameter ratio of 25-200, which is an appropriate length for inertial migration to occur 15,16,38,39 . A raw image of MCF-7 cells flowing in the microchannel is shown in Fig.…”