Cross-sectional Comparison of the Prevalence of Age-Associated Comorbidities and Their Risk Factors Between HIV-Infected and Uninfected Individuals: The AGEhIV Cohort Study

Schouten, Judith; Wit, Ferdinand W. N. M.; Stolte, Ineke G.; Kootstra, Neeltje A.; Valk, Marc van der; Geerlings, Suzanne E.; Prins, Maria; Reiss, Peter

doi:10.1093/cid/ciu701

Cited by 654 publications

(563 citation statements)

References 42 publications

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“…PLWH have higher rates of cardiovascular morbidities, typically kidney, lung and liver, and encephalitic morbidities, and emergence of tumors, and these higher prevalences are almost certainly related to three major causes in the HIV context: negative effects of antiretrovirals (ARVs), direct impact of HIV infection, and higher cardiovascular risk profile (Costagliola, 2014;Schouten et al, 2014). However, although the development of these comorbidities is also associated with aging in the general population, it is likely that elderly PLWH will face different heath challenges (Pathai, Bajilan, Landay, & High, 2014).…”

Section: Introductionmentioning

confidence: 99%

Impact of age on care pathways of people living with HIV followed up in hospital

et al. 2016

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The aging population of people living with human immunodeficiency virus (HIV) (PLWH) is exposed to a widening spectrum of non-AIDS-defining diseases. Thus, our objective was to compare the health care offered to PLWH according to age. We conducted a multicenter cross-sectional study on PLWH who consulted at one of 59 French HIV reference centers from 15th to 19th October 2012. Using our survey questionnaires, PLWH self-reported the medical care they received, whether or not tied to HIV infection monitoring, during the previous year. A total of 650 PLWH participated in the survey (median age 48 years, Interquartile range (IQR) 40-54), of which 95 were aged 60 years or over (14.5%). Compared to younger PLWH, 60-and-over PLWH were more often under complementary health insurance cover and less socially deprived based on the French EPICES (Evaluation of Precarity and Inequalities in Health Examination Centers) score. The elderly PLWH presented more comorbidities and less coinfections with hepatitis viruses. During health care, therapeutic education was less often offered to older PLWH (14% vs. 26%, p = .01), but this difference was mainly explained by sociodemographic factors and clinical status. Over the previous 6 months, 74% of PLWH who were followed up in hospital had also consulted another doctor, with a mean of 3.75 consultations (±4.18) without difference between age groups. After adjustment for sociodemographic factors and comorbidities, PLWH over 60 years were more likely to have consulted medical specialists as outpatients in the last 6 months (odds ratio [OR] = 2.63 [1.11-6.20]). Whatever their age, 13% of PLWH had been refused care on disclosure of their HIV status, and 27% of PLWH still did not disclose their HIV status to some caregivers. Coordinated health care throughout patients' lives is crucial, as health-care pathways evolve toward outpatient care as the patients get older. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Impact of age on care pathways of people living with HIV followed up in hospital

et al. 2016

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“…In recent years, the prevalence and incidence rates of kidney disease attributable to aging and metabolic problems (e.g., diabetes, hypertension, atherosclerosis) have increased [36] and may be higher among HIV-positive compared to HIV-negative persons [7, 37]. Therefore, in aging HIV-positive persons, potentially nephrotoxic drugs should be avoided.…”

Section: Renal Insufficiency: Increasingly More Common In the Aging Hmentioning

confidence: 99%

HIV and Aging – Perhaps Not as Dramatic as We Feared?

et al. 2018

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Ever since the introduction of highly active antiretroviral therapy (ART) in 1995, HIV infection has been linked to “metabolic” complications (insulin resistance, dyslipidemia, osteoporosis, and others). Studies suggested increased rates of myocardial infarction, renal insufficiency, neurocognitive dysfunction, and fractures in HIV-postitive patients. Even long-term suppression of HIV seemed to be accompanied by an excess of deleterious inflammation that could promote these complications. The aims of this viewpoint paper are to summarize recent data and to examine the possibility that the problem of aging-related morbidity in HIV might not be as dramatic as previously believed.

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“…It has been observed that with prolonged HIV infection or receiving treatment for longer duration develop many certain clinical conditions which are reflected so often during aging for example multiple co-morbidities, poly pharmacy, physical and cognitive impairment [14,15], functional decline, alterations in body composition, and increased vulnerability to stressors. The list of co morbidities (diseases or conditions that coexist with a primary disease) associated with HIV includes diseases of the lungs, liver, kidneys and heart and blood vessels, as well as neurological conditions and bone diseases [16,17].…”

Section: Antiretroviral Treatment Co Morbidities and Agingmentioning

confidence: 99%