Cross-Sectional Areas of Various Muscle Fibers in Skeletal Muscles of Athletes Training for Endurance, Strength, or Speed-Strength

Missina, S. S.; Kriuchkov, Andrey S.; Dikunets, M. A.; Myakinchenko, E. B.

doi:10.1134/s0362119722700074

Cited by 1 publication

(2 citation statements)

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“…While most of the fibers in postural muscles acquire high oxidativeness, locomotory muscles exhibit a mixed population of oxidative as well as glycolytic fibers (Pette, 2002 ). The oxidativeness of the fibers is determined by the mitochondrial density, and the fiber composition of different muscle groups varies in a species‐specific manner (Curry et al., 2012 ; Missina et al., 2022 ). The limb muscles of burst runners like cheetahs, deer, and mice are rich in glycolytic fibers, whereas those of long‐distance movers like elephants are rich in oxidative fibers (Curry et al., 2012 ; Goto et al., 2013 ; Hyatt et al., 2010 ).…”

Section: Introductionmentioning

confidence: 99%

“…The limb muscles of burst runners like cheetahs, deer, and mice are rich in glycolytic fibers, whereas those of long‐distance movers like elephants are rich in oxidative fibers (Curry et al., 2012 ; Goto et al., 2013 ; Hyatt et al., 2010 ). Mammals (like humans, goats, and cattle) that are intermediate possess limb muscles containing a mixture of both oxidative and glycolytic fibers (Missina et al., 2022 ). Further studying SkM development in goats will bridge several gaps in knowledge like its contribution to whole‐body energy expenditure, differential role muscles from different locations, and nonshivering thermogenesis mechanisms in SkM.…”

Section: Introductionmentioning

confidence: 99%

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Developmental dynamics of mitochondrial fission and fusion proteins in functionally divergent skeletal muscles of goat

Pani,

Senapati,

Pati

et al. 2024

Physiological Reports

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During skeletal muscle development, the intricate mitochondrial network formation relies on continuous fission and fusion. This process in larger mammals differs from rodents, the most used animal models. However, the expression pattern of proteins regulating mitochondrial dynamics in developing skeletal muscle remains unexplored in larger mammals. Therefore, we characterized the cellular expression and tissue‐level distribution of these proteins during development taking goat as a model. We have performed histological and immunohistochemical analyses to study metabolic features in various muscles. Neonatal muscles display uniform distribution of mitochondrial activity. In contrast, adult muscles exhibit clear distinctions based on their function, whether dedicated for posture maintenance or facilitating locomotion. Mitochondrial fission proteins like DRP‐1, MFF, and fusion proteins like MFN‐1 and 2 are abundantly expressed in neonatal muscles. Fission proteins exhibit drastic downregulation with limited peripheral expression, whereas fusion proteins continue to express in a fiber‐specific manner during adulthood. Locomotory muscles exhibit different fibers based on mitochondrial activity and peripheralization with high SDH activity. The proximity ligation assay between MFN1 and MFN2 demonstrates that their interaction is restricted to subsarcolemmal mitochondria in adult fibers while distributed evenly in neonatal fibers. These differences between postural and locomotory muscles suggest their physiological and metabolic properties are different.

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