The variability in clinical presentation and clinical course of patients with myocardial bridges (MB) hinders their management. Therefore, we assessed the correlation between the clinical profile of three patients and their coronarography data, coronary computerized tomography and the hemodynamic analysis of intracoronary pressure indexes measured with pressure wire. We studied validated indexes of coronary physiology; the resting distal coronary to aortic pressure ratio (Pd/Pa), Fractional Flow Reserve (FFR) and Diastolic Pressure Ratio (DPR). In addition, we propose specific systolic dynamic coronary compression (DCC) severity indexes in patients with MB; maximum percentage fall in systolic pressure at the end of systole (Δp/Pa%) and FFR/DPR ratio, among others. Cases 1 and 2 were mild (both with or without betablocker treatment) and similar among them (no anatomic or angiographic differences). However, they do manifest normal overall or mildly impacted translesional pressure ratios without a clear diastolic compromise. Case 3 had severe MB, which suggested that severe clinical presentation is associated with longer and deeper MB and more tortuosity, as well as greater systolic and diastolic angiographic DCC with intracoronary nitroglycerine (NTGic). Case 3 also showed lower basal values of conventional coronary physiology indexes that further worsened with NTGic and hyperemia with adenosine, consistent with greater DCC. Whilst treatment with betablockers is beneficial in all cases, there may be a greater response in patients with more dynamic systolic compromise (greater Δp/ Pa%, lower FFR/DPR ratio in hyperemia) in the intracoronary hemodynamic study. We believe the proposed ratios could help to identify patients who will present more severe angina, a higher number of events, and who will benefit most from intense beta-blocker treatment. So, in patients with MB, a complete anatomical and functional evaluation, including specific physiological indexes, would probably be recommended to predict their clinical course and guide treatment strategies.