Cross-Sectional and Longitudinal Effects of CREB1 Genotypes on Individual Differences in Memory and Executive Function: Findings from the BLSA

Wolf, Claudia; An, Yang; Tanaka, Toshiko; Bilgel, Murat; González, Christopher; Triolo, Melissa Kitner; Resnick, Susan M.

doi:10.3389/fnagi.2017.00142

Cited by 11 publications

(6 citation statements)

References 71 publications

(82 reference statements)

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“…Among the transcription factors identified was CREB1 (cAMP Responsive Element Binding Protein 1). Interestingly, CREB1 has been shown to play an important role in regulating expression of genes involved in memory (both long-term and working memory), executive functions, and Alzheimer’s disease 45 . Another transcription factor identified was SP1 (specificity protein 1).…”

Section: Discussionmentioning

confidence: 99%

The Western Diet Regulates Hippocampal Microvascular Gene Expression: An Integrated Genomic Analyses in Female Mice

Nuthikattu

Milenković

Rutledge

et al. 2019

Sci Rep

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Hyperlipidemia is a risk factor for dementia, and chronic consumption of a Western Diet (WD) is associated with cognitive impairment. However, the molecular mechanisms underlying the development of microvascular disease in the memory centers of the brain are poorly understood. This pilot study investigated the nutrigenomic pathways by which the WD regulates gene expression in hippocampal brain microvessels of female mice. Five-week-old female low-density lipoprotein receptor deficient (LDL-R−/−) and C57BL/6J wild type (WT) mice were fed a chow or WD for 8 weeks. Metabolics for lipids, glucose and insulin were determined. Differential gene expression, gene networks and pathways, transcription factors, and non-protein coding RNAs were evaluated by genome-wide microarray and bioinformatics analysis of laser captured hippocampal microvessels. The WD resulted in differential expression of 2,412 genes. The majority of differential gene expression was attributable to differential regulation of cell signaling proteins and their transcription factors, approximately 7% was attributable to differential expression of miRNAs, and a lesser proportion was due to other non-protein coding RNAs, primarily long non-coding RNAs (lncRNAs) and small nucleolar RNAs (snoRNAs) not previously described to be modified by the WD in females. Our findings revealed that chronic consumption of the WD resulted in integrated multilevel molecular regulation of the hippocampal microvasculature of female mice and may provide one of the mechanisms underlying vascular dementia.

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Section: Discussionmentioning

confidence: 99%

The Western Diet Regulates Hippocampal Microvascular Gene Expression: An Integrated Genomic Analyses in Female Mice

Nuthikattu

Milenković

Rutledge

et al. 2019

Sci Rep

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“…The critical nature of CREB signaling for neural plasticity and cognitive performance suggests that this pathway may be dysfunctional in neurodegenerative diseases in which memory and cognitive function are impaired (Cowburn et al, 1992b;Schnecko et al, 1994b;Yamamoto-Sasaki et al, 1999a). Importantly, single nucleotide polymorphisms (SNPs) in CREB1 and CREBBP (which encodes CBP) have been associated with accelerated cognitive decline and impaired episodic memory, semantic memory and executive function (Barral et al, 2014;Wolf et al, 2017). These types of memory, and episodic memory in particular, are disrupted in AD, supporting a link between dysfunctional CREB and the types of memory and cognitive functions impacted in AD (Gold and Budson, 2008).…”

Section: Creb In the Ad Brainmentioning

confidence: 99%

CREB signals as PBMC-based biomarkers of cognitive dysfunction: A novel perspective of the brain-immune axis

Bartolotti

Lazarov

2019

Brain, Behavior, and Immunity

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To date, there is no reliable biomarker for the assessment or determination of cognitive dysfunction in Alzheimer's disease and related dementia. Such a biomarker would not only aid in diagnostics, but could also serve as a measure of therapeutic efficacy. It is widely acknowledged that the hallmarks of Alzheimer's disease, namely, amyloid deposits and neurofibrillary tangles, as well as their precursors and metabolites, are poorly correlated with cognitive function and disease stage and thus have low diagnostic or prognostic value. A lack of biomarkers is one of the major roadblocks in diagnosing the disease and in assessing the efficacy of potential therapies. The phosphorylation of cAMP Response Element Binding protein (pCREB) plays a major role in memory acquisition and consolidation. In the brain, CREB activation by phosphorylation at Ser133 and the recruitment of transcription cofactors such as CREB binding protein (CBP) is a critical step for the formation of memory. This set of processes is a prerequisite for the transcription of genes thought to be important for synaptic plasticity, such as Egr-1. Interestingly, *

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“…Previous studies on rs2253206 were mostly about panic disorder and memory, but less about depression [ 8 , 29 , 30 ]. Interestingly, in Ma et al's study, GG genotype of rs2253206 was susceptible to depression when exposed to high negative life events, but our study found that rs2253206 AA genotype increases the susceptibility to depression [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation between variants of the CREB1 and GRM7 genes and risk of depression

et al. 2023

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The pathogenesis of depression involves cAMP-response element binding protein1 (CREB1) and metabotropic glutamate receptor 7 (GRM7), and their genetic polymorphisms may affect susceptibility to depression. The purpose of this study was to investigate whether the CREB1 polymorphisms rs2253206 and rs10932201 and the GRM7 polymorphism rs162209 are associated with the risk of depression. Using polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing, we analyzed the rs2253206, rs10932201, and rs162209 frequencies in 479 patients with depression and 329 normal controls. The results showed that the rs2253206 and rs10932201 polymorphisms were significantly associated with an increased risk of depression. However, no association was found between rs162209 and depression risk. When the data were stratified for several disease-related variables, none of the three polymorphisms were found to be correlated to onset, disease severity, family history, or suicidal tendency. Thus, the present findings indicate that the CREB1 polymorphisms rs2253206 and rs10932201 may be related to the occurrence of depression.

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Cross-Sectional and Longitudinal Effects of CREB1 Genotypes on Individual Differences in Memory and Executive Function: Findings from the BLSA

Cited by 11 publications

References 71 publications

The Western Diet Regulates Hippocampal Microvascular Gene Expression: An Integrated Genomic Analyses in Female Mice

The Western Diet Regulates Hippocampal Microvascular Gene Expression: An Integrated Genomic Analyses in Female Mice

CREB signals as PBMC-based biomarkers of cognitive dysfunction: A novel perspective of the brain-immune axis

Correlation between variants of the CREB1 and GRM7 genes and risk of depression

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