Cross-Sectional and Longitudinal Assessment of Structural Brain Alterations in Melancholic Depression

Soriano‐Mas, Carles; Hernández‐Ribas, Rosa; Pujol, Jesús; Urretavizcaya, Mikel; Deus, Joan; Harrison, Ben J; Ortiz, Héctor; López‐Solà, Marina; Menchón, J.M.; Cardoner, Narcı́s

doi:10.1016/j.biopsych.2010.07.029

Cited by 135 publications

(138 citation statements)

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“…Potential limitations of the current study should be considered, these include the absence of a face-to-face structured diagnostic interview schedule and the lack of hospital-based sampling. The large sample size may, however, overcome some of these difficulties and community based population sampling may yield more generalizable findings than those based on clinically ascertained samples alone 8,53 . The current investigation, by avoiding the combination of clinically and methodologically diverse samples, may also have ameliorated several important confounds such as differences due to different healthcare systems and illness related conditions including age of onset and duration of illness.…”

Section: Discussionmentioning

confidence: 99%

“…Prefrontal cortex and limbic areas are fundamental to emotion processing and mood regulation 3 , and these areas have also been consistently implicated in imaging studies of MDD [4][5][6] . As the use of automated methods such as voxel-based morphometry 7,8 and Freesurfer 9 have increased, this has expanded the search across the whole brain. In general, structural abnormalities have been reported across diverse brain networks in MDD.…”

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confidence: 99%

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Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

Shen

Reus

Adams

et al. 2016

Preprint

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Previous reports of altered grey and white matter structure in Major Depressive Disorder (MDD) have been inconsistent. Recent meta-analyses have, however, reported reduced hippocampal grey matter volume in MDD and reduced white matter integrity in several brain regions. The use of different diagnostic criteria, scanners and imaging sequences may, however, obscure further anatomical differences. In this study, we tested for differences in subcortical grey matter volume (n = 1157) and white matter integrity (n = 1089) between depressed individuals and controls in the subset of 8590 UK Biobank Imaging study participants who had undergone depression assessments. Whilst we found no significant differences in subcortical volumes, significant reductions were found in depressed individuals versus controls in global white matter integrity, as measured by fractional anisotropy ( Major Depressive Disorder (MDD) is a common psychiatric illness, affecting between 5 and 30% of the population which accounts for around 10% of all days lived with disability 1

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

Shen

Reus

Adams

et al. 2016

Preprint

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“…29,32 A 7-year longitudinal study used morphometric analysis to assess age-related abnormalities of grey and white matter in individuals with melancholic MDD. 33 Results from that study indicate that several structures exhibit accelerated volumetric reductions in individuals with melancholic MDD, including periventricular white matter near the striatum and the right lingual and left caudal middle temporal gyrus. The study included older participants (mean age > 60 yr) with a relatively late age at onset of melancholic MDD (mean age at onset > 50 yr).…”

Section: Introductionmentioning

confidence: 90%

“…Soriano-Mas and colleagues 33 found that periventricular white matter proximal to the putamen exhibited age-related reductions in volume in patients with melancholic MDD. In this context, our results of accelerated putamen grey matter reductions in patients with MDD may be associated with accelerated aging of proximal white matter.…”

Section: J Psychiatry Neurosci 2017;42(3)mentioning

confidence: 99%

Accelerated aging of the putamen in patients with major depressive disorder

Sacchet

Camacho

Livermore

et al. 2017

JPN

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IntroductionMajor depressive disorder (MDD) is primarily characterized by depressed mood and a blunted experience of pleasure (i.e., anhedonia). 1 The disorder is prevalent and chronic and represents a substantial personal, social and economic burden. [2][3][4] Neuroscience promises to elucidate mechanisms under lying depressive pathophysiology, leading to more effective approaches to the prevention and treatment of this debilitating disorder.Considerable evidence indicates that reward processing is dysfunctional in individuals with MDD. 5,6 The basal ganglia (BG) are a set of subcortical structures, including the striatum (caudate and putamen), nucleus accumbens and pallidum, that are critically involved in these reward processing steps. 7Previously research has indicated that depressed individuals have decreased activation in the striatum, 5,6 and some investigators have hypothesized that this abnormal activity affects decision-making. 5 Research in both animals and humans suggests that the dorsal striatum is involved in action selection and initiation and in encoding and integrating sensorimotor, cognitive and motivational/emotional information.8 Current evidence is mixed regarding specific roles of the putamen and caudate in reward processing. The results of several studies using fMRI suggest that whereas the putamen specifi cally encodes reward-related feedback, the caudate encodes both reward and punishment feedback.9,10 Finally, researchers have reported that the putamen is activated most strongly during anticipation of reward, whereas the caudate is activated most strongly during the receipt of reward. 8,10,11 A growing body of research indicates that adults with MDD have smaller volumes of the caudate 12-15 and putamen 13,14,16,17 than healthy controls. Postmortem studies have also reported smaller putamen volumes in depressed than in nondepressed adults. 18 It is important to note that these studies typically include adult samples with a mean age older than 40 years. Depression-associated differences in BG volumes are less consistent in samples of both younger adults 19,20 and adolescents. 21 It appears, therefore, that this discrepancy is associated with age differences in the study Background: Growing evidence indicates that major depressive disorder (MDD) is characterized by accelerated biological aging, including greater age-related changes in physiological functioning. The disorder is also associated with abnormal neural reward circuitry, particularly in the basal ganglia (BG). Here we assessed age-related changes in BG volume in both patients with MDD and healthy control participants. Methods: We obtained whole-brain T 1 -weighted images from patients with MDD and healthy controls. We estimated grey matter volumes of the BG, including the nucleus accumbens, caudate, pallidum and putamen. Volumes were assessed using multivariate analysis of covariance (MANCOVA) with age as a covariate, followed by appropriate post hoc tests. Results: We included 232 individuals (116 patients with MDD) in our analy...

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“…Although much less numerous than ROI-based studies, these voxel-based morphometry and cortical thickness studies have provided additional evidence of reduced volumes and thinning of prefrontal, hippocampal, and cingulate regions in association with the presence and severity of MDD symptoms, 28,[31][32][33][34] as well as implicating other brain regions not previously assessed in ROI-based studies of MDD such as the insula. 35 There is evidence that some of the above structural imaging findings reported in MDD samples may be influenced by illness chronicity and treatment effects. 30 However, there have been morphometric MRI investigations carried out with first-episode MDD patients (a proportion of which never exposed to treatment), and these studies have indicated that findings such as reduced hippocampal and frontal cortical volumes are detectable since early disease stages.…”

Section: Overview Of Structural and Resting-state Functional Neuroimamentioning

confidence: 99%

Structural and Functional Neuroimaging Studies in Major Depressive Disorder With Psychotic Features: A Critical Review

Busatto

2013

Schizophrenia Bulletin

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The relationship between major depressive disorder with psychotic (MDDP) features and schizophrenia has long been recognized, and the neurobiological boundaries between these disorders can nowadays be investigated using neuroimaging techniques. This article provides a critical review of such studies, addressing how they support a dimensional approach to the nosology and pathophysiology of psychotic disorders. A proportion of neuroimaging studies carried out to date indicate that MDDP subjects display structural and functional abnormalities in some brain regions specifically implicated in the pathophysiology of mood disorders, such as the subgenual cingulate cortex. This reinforces the validity of the classification of MDDP in proximity to major depression without psychosis. There is some neuroimaging evidence that MDDP may be associated with additional brain abnormalities relative to nonpsychotic major depression although less prominently in comparison with findings from the neuroimaging literature on schizophrenia. Brain regions seen as critical both to emotional processing and to models of psychotic symptoms, such as the hippocampus, insula, and lateral prefrontal cortex, have been implicated in separate neuroimaging investigations of either schizophrenia or major depression, as well as in some studies that directly compared depressed patients with and without psychotic features. These brain regions are key targets for future studies designed to validate imaging phenotypes more firmly associated with MDDP, as well as to investigate the relationship between these phenotypes and possible etiological influences for MDDP.

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Cross-Sectional and Longitudinal Assessment of Structural Brain Alterations in Melancholic Depression

Cited by 135 publications

References 60 publications

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

Accelerated aging of the putamen in patients with major depressive disorder

Structural and Functional Neuroimaging Studies in Major Depressive Disorder With Psychotic Features: A Critical Review

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