“…During the decades of 50 and 60, many pioneering works were developed by Pessoa et al (1953Pessoa et al ( , 1955Pessoa et al ( , 1957 in Brazilian Northeast, Brener and Mourão (1956), Rodrigues da Silva (1957), Klotzel (1962Klotzel ( , 1963 Katz and Brener (1966), Barbosa (1966Barbosa ( , 1968, Prata and Schroeder (1967), and Prata and Bina (1968), about morbidity and disease evolution, in areas of Minas Gerais, Alagoas, Pernambuco, and Bahia and many others cited by Coura et al (1980Coura et al ( -1992, which resume epidemiological, laboratorial and clinical studies about the disease until that time.…”