Cross-Sectional Analysis of Met235→Thr Variant of Angiotensinogen Gene in Severe, Familial Hypertension

Bennett, Craig L.; Schrader, Andrew P.; Morris, Brian J.

doi:10.1006/bbrc.1993.2554

Cited by 111 publications

(56 citation statements)

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“…Consistent with this, no positive relation between TT-genotype and BP has been seen in either of other offspring studies of which we are aware. 13,14 Thus, one may speculate that genetically predisposed individuals may have other genetic combinations, which protect against the prohypertensive mechanisms associated with the TT genotype. Without knowing the link between the TT-genotype and BP 44 it is difficult to suggest a mechanism by which the TT genotype could have a hypotensive effect in genetically disposed individuals.…”

Section: Figurementioning

confidence: 99%

Renal Haemodynamics are not Related to Genotypes in Offspring of Parents with Essential Hypertension

Skov

Madsen

Hansen

et al. 2006

J Renin Angiotensin Aldosterone Syst

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Introduction. The pathogenesis of essential hypertension (EH) has a major genetic component and is associated with renal abnormalities. Normotensive offspring of hypertensive parents are likely to develop EH and are a suitable population for identifying possible relations between genetic and renal abnormalities. Methods. We investigated if renin-angiotensin-aldosterone system associated genotypes (angiotensinogen [M235T] and ACE [I/D]) are related to blood pressure (BP), renal haemodynamics and sodium excretion in sex and age-matched (18—35 years) healthy Caucasian offspring of either two parents with EH (n=101, EH-offspring) or two normotensive parents (n=50, controls). The alpha-adducin polymorphism (G460W) was also investigated. Results. Compared to controls, BP, heart rate, renal vascular resistance (RVR) and urinary sodium excretion were, respectively, 5%, 7%, 15% and 20% higher in EH-offspring. In controls, the TT-genotype of the M235T angiotensinogen polymorphism was associated with higher BP and higher plasma angiotensinogen. By contrast, in EHoffspring the TT-genotype was associated with lower BP and unchanged plasma angiotensinogen. Plasma angiotensinogen correlated positively with BP in EH-offspring, with a similar tendency (p=0.08) in controls. The distributions of the three candidate polymorphisms were similar in EH-offspring and controls. There were no associations between any of the polymorphisms and any of the renal parameters measured. Conclusion. The markedly greater RVR, proportionally larger than the greater BP, supports a role for RVR in the pathogenesis of EH. The lack of association between the candidate polymorphisms and the investigated parameters, even in this homogenous and for hypertension strongly predisposed group, suggests that the polymorphisms investigated do not play important roles in the pathogenesis of hypertension.

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Section: Figurementioning

confidence: 99%

Renal Haemodynamics are not Related to Genotypes in Offspring of Parents with Essential Hypertension

Skov

Madsen

Hansen

et al. 2006

J Renin Angiotensin Aldosterone Syst

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“…A polymorphism in exon 2, in which methionine at position 235 is replaced by threonine (M235T variant) has been associated with essential hypertension in both whites (Jeunemaitre et al, 1992) and Japanese (Hata et al, 1994, Nishiuma et al, 1995. However, other studies have failed to show an association of the M235T variant with essential hypertension in whites at British (Caulfield et al, 1994), Australian (Bennett et al, 1993) and Japanese (Morise et al, 1995) population. Another polymorphism in exon 2, in which threonine at position 174 is replaced by methionine (T174M variant), has also been associated with essential hypertension in whites (Jeunemaitre et al, 1992) and Japanese (Morise et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Angiotensin converting enzyme I/D, angiotensinogen T174M-M235T and angiotensin II type 1 receptor A1166C gene polymorphisms in Turkish hypertensive patients

Ağaçhan

İsbır²,

Yılmaz³

et al. 2003

Exp Mol Med

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A bstractEssential hypertension is a m ultifactorial disease in w hich genetic and envirom ental factors play an im portant role. These factors differ in each population. As there are no existing data for the Turkish population, w e investigated four Renin Angiotensin System (RAS) gene polym orphism s, the angiotensin converting enzym e (ACE), angiotensinogen (AG N) M 235T/T174M and angiotensin II type 1 receptor A1166C polym orphism in 109 hypertensive and 86 norm otensive Turkish subjects. Polym erase Chain Reaction (PCR) and Restriction Fragm ent Length Polym orphism (RFLP), and agarose gel electrophoresis tecniques w ere used to determ ine these polym orphism . The frequencies of person that carry ACE D allel (DD+ID) w as significantly higher in hypertensive group (99.1% ) than controls (80%) (P 0.000). M235T TT genotype was also found significantly higher in hypertensives than control group (20% vs 2.7% ; P 0.001). The frequency of AG N 174M allele w as higher in the hypertensive group than control subjects (8.76% vs 4.81% ). Frequency of ATR1 C allele (AC+CC genotypes) w as found higher hypertensives than controls (39.4% vs 25.9% ; P = 0.054). O ur results suggest that an interaction exists between the RAS genes and hypertension in Turkish population.

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“…[3][4][5] It has been observed that the 235T allele frequency differs among different ethnic groups studied. In the white population it varies from 0.35 to 0.45, 3,[6][7][8][9] while in the Japanese the range increases from 0.6-0.75. [10][11][12] The highest prevalence of this allele is found among Africans, where it varies from 0.84 to 0.93.…”

Section: Introductionmentioning

confidence: 99%

Effects of the angiotensinogen gene M235T and A(-6)G variants on blood pressure and other vascular risk factors in a Spanish population

Rodríguez‐Pérez

Rodrı́guez-Esparragón

Hernández‐Perera

et al. 2000

J Hum Hypertens

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Angiotensinogen (AGT) gene polymorphism has shown significant differences in the allelic frequencies between hypertensive and normotensive subjects. This allele frequency varies among ethnic groups. There are still some controversies related to the 235T-variant as a marker for essential hypertension. As part of an extensive case-control study carried out in a Spanish population, we selected the 237 subjects with a diagnosis of essential hypertension according to the established criteria. A group of 242 normotensives matched for age and gender was used as control. Smoking habits, a previous diabetes and hypertension medical history, body mass index (BMI) and blood pressure (BP) values were recorded. Glucose, plasma creatinine, lipid profile with Lp(a), homocysteine and microalbuminuria were measured. Angiotensinogen M235T-gene polymorphism was

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Cross-Sectional Analysis of Met235→Thr Variant of Angiotensinogen Gene in Severe, Familial Hypertension

Cited by 111 publications

References 0 publications

Renal Haemodynamics are not Related to Genotypes in Offspring of Parents with Essential Hypertension

Renal Haemodynamics are not Related to Genotypes in Offspring of Parents with Essential Hypertension

Angiotensin converting enzyme I/D, angiotensinogen T174M-M235T and angiotensin II type 1 receptor A1166C gene polymorphisms in Turkish hypertensive patients

Effects of the angiotensinogen gene M235T and A(-6)G variants on blood pressure and other vascular risk factors in a Spanish population

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