Cross-section measurement for the 7Li(p,α)4He reaction at proton energies 0.6 – 2 MeV

Taskaev, Sergey; Bikchurina, Marina; Bykov, Timofey; Kasatov, D. A.; Kolesnikov, Iaroslav; Makarov, A. N.; Ostreinov, G. M.; Савинов, С. С.; Sokolova, Evgeniia

doi:10.1016/j.nimb.2022.06.010

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…There is nothing surprising. Sometimes the data in different libraries can differ, such as the values of the 7 Li(p,𝛼) 4 He reaction cross section [8].…”

Section: Jinst 18 P02020mentioning

confidence: 99%

Validation and optimization of the epithermal neutron flux detector using the ⁷¹Ga(n,γ)⁷²Ga reaction

et al. 2023

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An intense epithermal neutron flux is necessary for boron neutron capture therapy (BNCT), a promising technique for the treatment of malignant tumors. The epithermal neutron flux is an essential characteristic of the BNCT neutron beam and its measurement is directly related to the reliability of the treatment planning system. Such a tool could be a cylindrical activation detector using 71Ga(n,γ)72Ga reaction. This paper describes a detector made in the likeness of the previously proposed one and presents the results of numerical simulation of the detector sensitivity and its experimental use. The paper notes the difference between the simulated sensitivity of the detector and the sensitivity of the previously proposed one and makes assumptions about the reason for this difference. The work also proposes an improvement of the detector, which allows not only to reduce the contribution of fast neutrons to the detector sensitivity, but also to provide a new opportunity to refine the spectrum of neutrons that are most effective for the treatment of deep-seated tumors.

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“…There is nothing surprising. Sometimes the data in different libraries can differ, such as the values of the 7 Li(p,𝛼) 4 He reaction cross section [8].…”

Section: Jinst 18 P02020mentioning

confidence: 99%

Validation and optimization of the epithermal neutron flux detector using the ⁷¹Ga(n,γ)⁷²Ga reaction

et al. 2023

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“…The capture of a neutron by lithium-7 leads to the appearance of the lithium-8 isotope, which almost instantly turns into the beryllium-8 isotope as a result of beta minus decay. The latter also decays almost instantly into two α-particles with a total energy of 17.34 MeV [ 10 ]. Therefore, the capture of a neutron by lithium-7, as well as by lithium-6, provides a local 100% energy release even 3.6 times greater.…”

Section: Introductionmentioning

confidence: 99%

Study of Lithium Biodistribution and Nephrotoxicity in Skin Melanoma Mice Model: The First Step towards Implementing Lithium Neutron Capture Therapy

Taskaeva

Kasatovа

Surodin

et al. 2023

Life

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Boron neutron capture therapy (BNCT) is one of the promising treatment methods for malignant melanoma. The main issue of this technology is the insufficient selectivity of 10B accumulation in tumor cells. As a result of the neutron absorption by boron, an 84% energy release occurred within the cell by the nuclear reaction 10B (n, α)7Li, which lead to tumor cell death. The use of lithium instead of boron brings a new unique opportunity—local 100% energy release—since all products of the 6Li (n, α)3H reaction have high linear energy transfer characteristics. The aim of this study was to determine the concentrations of Li in the tumor, skin, blood, brain and kidney in experimental animals with B16 melanoma and to analyze the potential Li toxicity after lithium carbonate administration at single doses of 300 and 400 mg/kg. Lithium carbonate was chosen since there is a long-term experience of its use in clinical practice for the treatment of psychiatric disorders. The inductively coupled plasma atomic emission spectrometry was used to evaluate Li concentrations in tissue samples. The accumulation efficiency of Li in the tumor was the highest at a time point of 30 min (22.4 µg/g; at a dose of 400 mg/kg). Despite the high lithium accumulation in the kidneys, the pathological changes in kidney tissues were not found. Thus, lithium may actually be used for the Li-NCT development and future studies can be conducted using 6Li and following irradiation of tumor cells using the schemes of lithium administration tested in this work.

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The Li battery digital twin – Combining 4D modelling, electro-chemistry, neutron, and ion-beam techniques

Möller,

Schwab,

Seidlmayer

et al. 2024

Journal of Power Sources

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Cross-section measurement for the 7Li(p,α)4He reaction at proton energies 0.6 – 2 MeV

Cited by 5 publications

References 18 publications

Validation and optimization of the epithermal neutron flux detector using the ⁷¹Ga(n,γ)⁷²Ga reaction

Validation and optimization of the epithermal neutron flux detector using the ⁷¹Ga(n,γ)⁷²Ga reaction

Study of Lithium Biodistribution and Nephrotoxicity in Skin Melanoma Mice Model: The First Step towards Implementing Lithium Neutron Capture Therapy

The Li battery digital twin – Combining 4D modelling, electro-chemistry, neutron, and ion-beam techniques

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Cross-section measurement for the 7Li(p,α)4He reaction at proton energies 0.6 – 2 MeV

Cited by 5 publications

References 18 publications

Validation and optimization of the epithermal neutron flux detector using the 71Ga(n,γ)72Ga reaction

Validation and optimization of the epithermal neutron flux detector using the 71Ga(n,γ)72Ga reaction

Study of Lithium Biodistribution and Nephrotoxicity in Skin Melanoma Mice Model: The First Step towards Implementing Lithium Neutron Capture Therapy

The Li battery digital twin – Combining 4D modelling, electro-chemistry, neutron, and ion-beam techniques

Contact Info

Product

Resources

About

Validation and optimization of the epithermal neutron flux detector using the ⁷¹Ga(n,γ)⁷²Ga reaction

Validation and optimization of the epithermal neutron flux detector using the ⁷¹Ga(n,γ)⁷²Ga reaction