Cross-resistance in Gulf killifish (Fundulus grandis) populations resistant to dioxin-like compounds

Oziolor, Elias M.; Dubansky, Benjamin; Burggren, Warren W.; Matson, Cole W.

doi:10.1016/j.aquatox.2016.03.019

Cited by 23 publications

(18 citation statements)

References 60 publications

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“…For example, down‐regulation of the AHR pathway and a corresponding diminished CYP1 response would be expected to be beneficial for exposure to the neurotoxic insecticide chlorpyrifos, which is bioactivated by CYP1, and in fact Elizabeth River larvae are resistant to chlorpyrifos (Clark & Di Giulio, 2012). In contrast, down‐regulation of the AHR pathway would be expected to sensitize fish to compounds detoxified by CYP1 enzymes, such as neurotoxic insecticides like the pyrethroid permethrin or the carbamate carbaryl, but Elizabeth River larvae were also resistant to these chemicals, as are DLC‐tolerant populations of F. grandis (Oziolor, Dubansky, Burggren, & Matson, 2016). These results suggest that evolved mechanisms other than CYP1‐mediated metabolism contribute to cross‐protection from some neurotoxic pesticides.…”

Section: Ecological Considerationsmentioning

confidence: 99%

When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations

Whitehead

Clark

Reid

et al. 2017

Evolutionary Applications

120

102

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For most species, evolutionary adaptation is not expected to be sufficiently rapid to buffer the effects of human‐mediated environmental changes, including environmental pollution. Here we review how key features of populations, the characteristics of environmental pollution, and the genetic architecture underlying adaptive traits, may interact to shape the likelihood of evolutionary rescue from pollution. Large populations of Atlantic killifish (Fundulus heteroclitus) persist in some of the most contaminated estuaries of the United States, and killifish studies have provided some of the first insights into the types of genomic changes that enable rapid evolutionary rescue from complexly degraded environments. We describe how selection by industrial pollutants and other stressors has acted on multiple populations of killifish and posit that extreme nucleotide diversity uniquely positions this species for successful evolutionary adaptation. Mechanistic studies have identified some of the genetic underpinnings of adaptation to a well‐studied class of toxic pollutants; however, multiple genetic regions under selection in wild populations seem to reflect more complex responses to diverse native stressors and/or compensatory responses to primary adaptation. The discovery of these pollution‐adapted killifish populations suggests that the evolutionary influence of anthropogenic stressors as selective agents occurs widely. Yet adaptation to chemical pollution in terrestrial and aquatic vertebrate wildlife may rarely be a successful “solution to pollution” because potentially adaptive phenotypes may be complex and incur fitness costs, and therefore be unlikely to evolve quickly enough, especially in species with small population sizes.

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Section: Ecological Considerationsmentioning

confidence: 99%

When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations

Whitehead

Clark

Reid

et al. 2017

Evolutionary Applications

120

102

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Section: Other ‐Omics and Evolutionary Toxicologymentioning

confidence: 99%

“…When adaptation to contamination is identified, possible fitness costs are some of the first targets to assess threats to adapted populations (Clark & Di Giulio, 2012; Oziolor, Dubansky, Burggren, & Matson, 2016b). These investigations take a targeted approach to explore effects on pathways likely affected by adaptation (Clark & Di Giulio, 2012; Oziolor et al., 2016b). On the other hand, with top‐down ‐omics approaches, understanding of transcriptomic, metabolomic, and proteomic differences in responsiveness and basal levels in adapted populations may inform possible fitness costs in a much more thorough manner (Bahamonde, Feswick, Isaacs, Munkittrick, & Martyniuk, 2016; Bundy, Davey, & Viant, 2008; Monsinjon & Knigge, 2007).…”

Section: Other ‐Omics and Evolutionary Toxicologymentioning

confidence: 99%

“…CYP1A; Hahn, 2002). It is also known that both basal and maximal induction levels of protein activity among reference populations of F. grandis are very similar (Oziolor et al., 2016b). Additionally, anthropogenic evolution (evolution in response to anthropogenic stressors) has been shown to result in the down‐regulation of both basal and maximum induction levels for this pathway (Oziolor et al., 2014).…”

Section: Gene Expression: Phenotypic Plasticity or Transitory Physiolmentioning

confidence: 99%

“…In other words, significant mortality and/or reproductive effects are required for population adaptation or “evolutionary rescue,” which is why this process should not be considered positively from a regulatory standpoint, but rather as evidence of chronic increased mortality. Another issue of concern following rapid adaption is the potential for fitness costs, both mechanistically related to the adapted phenotype, or completely independent (Clark & Di Giulio, 2012; Harbeitner et al., 2013; Meyer & Di Giulio, 2003; Oziolor et al., 2016b). While fitness costs in adapted populations are of concern where evolutionary rescue has occurred, it is also imperative to understand if other species in the same contaminated environments have also been affected.…”

Section: Applications Of Evolutionary Toxicologymentioning

confidence: 99%

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Evolutionary toxicology in an omics world

Oziolor

Bickham

Matson

2017

Evolutionary Applications

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Evolutionary toxicology is a young field that has grown rapidly in the past two decades. The potential of this field comes from the ability to link chemical contamination to multigenerational and population‐wide effects in various species. The advancements and rapidly decreasing costs of ‐omic tools are improving the power and resolution of evolutionary toxicology studies. In this manuscript, we aim to address the trajectories and perspectives for conducting evolutionary toxicology studies with ‐omic approaches. We discuss the complementarity of using multiple ‐omic tools (genomics, eDNA, transcriptomics, proteomics, and metabolomics) for utility in understanding the toxicological relevance of adaptive responses in populations. In addition, we discuss phenotypic plasticity and its relevance to transcriptomic studies in toxicology. As evolutionary toxicology grows and expands its capacity to link toxicology with population‐wide end points, we emphasize the applications of such studies in answering questions about ecological and population health, as well as future applicability to regulation. Thus, we aim to emphasize the enormous potential for evolutionary toxicology in an ‐omics world and give perspectives on the directions of future investigations.

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Evolutionary Toxicology—An Informational Tool for Chemical Regulation?

Oziolor

DeSchamphelaere

Lyon

et al. 2020

Enviro Toxic and Chemistry

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The Challenge:Evolutionary toxicology focuses on the drivers, mechanisms, and outcomes of pollution-driven genetic differentiation among populations. The focal questions address the types of chemical contamination acting as selective pressures; the genetics, epigenetics, and demography of impacted populations; as well as fitness costs and cross-resistances that may follow rapid adaptation. In this field, researchers incorporate tools from environmental chemistry, conservation genetics, population biology, and toxicology to understand the health and stability of impacted populations.Recent studies in evolutionary toxicology have illustrated diverse cases of population-wide adaptation to contamination (killifish, Hyalella, mosquitofish). Adaptation, by definition, is achieved through the localized loss of some individuals and genotypes and, thus, provides singular evidence of losses in biodiversity. Chemical regulations are generally supported by assessments that predict, largely through laboratory studies, the risks associated with chemical exposures. Evolutionary toxicology complements this approach by providing direct evidence of population and community impacts. Recent interest by the Society of Environmental Toxicology and Chemistry working group EVOGENERATE (Evolutionary and Multigenerational Effects of Chemicals) has launched discussions about the utility of evolutionary toxicology studies to inform chemical regulation. To further this discussion, one representative from each of 3 sectors, academia, government, and industry, was asked to provide opinions on the following questions:1) The considerable number of adaptive events reported in recent years suggests that current risk-assessment methods may not be exhaustive. What is risk assessment missing by not incorporating evolutionary toxicology endpoints to inform the regulation of toxic compounds? 2) Changes in the US Toxic Substances Control Act call for attention in 2 major aspects of predictive toxicology: organizational frameworks (e.g., adverse outcomes pathway) and fast screening methods (e.g., Omics, Tox21). Can evolutionary toxicology contribute to these advancements? 3) What needs to be done to make an evolutionary approach more accessible and useful to chemical regulation?

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Cross-resistance in Gulf killifish (Fundulus grandis) populations resistant to dioxin-like compounds

Cited by 23 publications

References 60 publications

When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations

When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations

Evolutionary toxicology in an omics world

Evolutionary Toxicology—An Informational Tool for Chemical Regulation?

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