Cross‐resistance and possible mechanisms of chlorpyrifos resistance in <i>Laodelphax striatellus</i> (Fallén)

Wang, Lihua; Zhang, Yueliang; Han, Zhaojun; Liu, Yanhe; Fang, Jichao

doi:10.1002/ps.1984

Cited by 67 publications

(39 citation statements)

References 16 publications

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“…For example, resistance to pesticides in insects is frequently achieved by overexpression of endogenous CEs that can inactivate these compounds [85-88]. Potentially therefore, combining a selective inhibitor of this enzyme with the pesticide, should result in increased toxicity of the latter to the organism.…”

Section: Expert Opinionmentioning

confidence: 99%

Carboxylesterase inhibitors

Hatfield

Potter

2011

Expert Opinion on Therapeutic Patents

102

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Introduction Carboxylesterases play major roles in the hydrolysis of numerous therapeutically active compounds. This is, in part, due to the prevalence of the ester moiety in these small molecules. However, the impact these enzymes may play on drug stability and pharmacokinetics is rarely considered prior to molecule development. Therefore, the application of selective inhibitors of this class of proteins may have utility in modulating the metabolism, distribution and toxicity of agents that are subjected to enzyme hydrolysis. Areas covered This review details the development of all such compounds dating back to 1986, but principally focuses on the very recent identification of selective human carboxylesterases inhibitors. Expert opinion The implementation of carboxylesterase inhibitors may significantly revolutionize drug discovery. Such molecules may allow for improved efficacy of compounds inactivated by this class of enzymes and/or reduce the toxicity of agents that are activated by these proteins. Furthermore, since lack of carboxylesterase activity appears to have no obvious biological consequence, these compounds could be applied in combination with virtually any esterified drug. Therefore, inhibitors of these proteins may have utility in altering drug hydrolysis and distribution in vivo. The characteristics, chemical and biological properties, and potential uses of such agents, are discussed here.

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Section: Expert Opinionmentioning

confidence: 99%

Carboxylesterase inhibitors

Hatfield

Potter

2011

Expert Opinion on Therapeutic Patents

102

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“…Resistance to chlorpyrifos has been reported in many insect species including Tetranychus evansi (581.5‐fold), Chrysoperla carnea (37‐fold), Chilo suppressalis (11.4–36.9‐fold), Choristoneura rosaceana (24.96‐fold), Helicoverpa armigera (2.6–24‐fold), Spodoptera litura (15.1–55.1‐fold) and Bemisia tabaci (21.8‐fold), with different mechanisms reported, such as mutation and amplification of the acetylcholinesterase‐1 ( T. evansi ), target‐site insensitivity ( C. suppressalis ) and metabolic mechanisms due to enhanced cytochrome P450, esterase and glutathione‐ S ‐transferase activities ( C. rosaceana , C. carnea , H. armigera , S. litura and B. tabaci ). Previous studies on laboratory‐selected populations showed that L. striatellus could develop a high level of resistance to chlorpyrifos (188.55‐fold), and enhanced activity of carboxylesterase was suggested as a mechanism of the resistance . Further study reported that Ls.CarE1 overexpression might be involved in chlorpyrifos resistance .…”

Section: Introductionmentioning

confidence: 97%

Biochemical and molecular characterisation and cross‐resistance in field and laboratory chlorpyrifos‐resistant strains of Laodelphax striatellus (Hemiptera: Delphacidae) from eastern China

Han

2013

Pest Management Science

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“…The most common management strategy to control these planthoppers is chemical treatments. However, this inevitably leads to the development of insecticide resistance, insect resurgence, and serious environmental pollution [1]–[5]. Alternative control strategies must be developed.…”

Section: Introductionmentioning

confidence: 99%

RNA Interference Depletion of the Halloween Gene Disembodied Implies its Potential Application for Management of Planthopper Sogatella furcifera and Laodelphax striatellus

Wan

Song

et al. 2014

PLoS ONE

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Sogatella furcifera and Laodelphax striatellus are economically important rice pests in China by acting as vectors of several rice viruses, sucking the phloem sap and blocking the phloem vessels. Ecdysteroid hormone 20-hydroxyecdysone regulates insect development and reproduction. A cytochrome P450 monooxygenase CYP302A1 (22-hydroxylase), encoded by the Halloween gene disembodied (dib), plays a critical role in ecdysteroidogenesis. The objective of this study is to test whether dib genes are potential targets for RNA interference-based management of S. furcifera and L. striatellus. We cloned and characterized Sfdib and Lsdib. The open reading frame regions of dib genes were generated and used for designing and constructing dsRNA fragments. Experiments were conducted using oral delivery of dsdib to investigate the effectiveness of RNAi in S. furcifera and L. striatellus nymphs. Real-time quantitative reverse transcriptase-PCR analysis demonstrated that continuous ingestion of dsdib at the concentration of 0.01, 0.05 and 0.50 mg/ml diminished Sfdib expression levels by 35.9%, 45.1% and 66.2%, and ecdysone receptor (SfEcR) gene mRNA levels by 34.0%, 36.2% and 58.5% respectively in S. furcifera, and decreased Lsdib expression level by 18.8%, 35.8% and 56.7%, and LsEcR mRNA levels by 25.2%, 46.8% and 68.8% respectively in L. striatellus. The reduction in dib and EcR transcript abundance resulted in observable phenotypes. The development of nymphs was impaired and the survival was negatively affected. Our data will enable the development of new insect control strategies and functional analysis of vital genes in S. furcifera and L. striatellus nymphs.

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Cross‐resistance and possible mechanisms of chlorpyrifos resistance in Laodelphax striatellus (Fallén)

Cited by 67 publications

References 16 publications

Carboxylesterase inhibitors

Carboxylesterase inhibitors

Biochemical and molecular characterisation and cross‐resistance in field and laboratory chlorpyrifos‐resistant strains of Laodelphax striatellus (Hemiptera: Delphacidae) from eastern China

RNA Interference Depletion of the Halloween Gene Disembodied Implies its Potential Application for Management of Planthopper Sogatella furcifera and Laodelphax striatellus

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