Cross‐reactivity to fish and chicken meat – a new clinical syndrome

Kuehn, Annette; Codreanu‐Morel, Françoise; Lehners‐Weber, Christiane; Doyen, Virginie; Gomez-André, S-A; Bienvenu, F.; Fischer, J; Ballardini, Natalia; Hage, Marianne van; Perotin-Collard, Jeanne-Marie; Silcret-Grieu, S; Chabane, H.; Hentges, François; Ollert, Markus; Hilger, Christiane; Morisset, M.

doi:10.1111/all.12968

Cited by 79 publications

(84 citation statements)

References 30 publications

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“…Indeed, IgE sensitization patterns to these three allergens were usually either nonreactive or reactive to more than one of these allergens. The correlations between IgE score pairs were highly significant, thereby confirming the previously known association of IgE sensitization existing between these allergens in dogs and humans …”

Section: Discussionsupporting

confidence: 83%

“…Most recently, an unexpected association between fish and chicken was noted, with 30% of chicken‐allergic patients also found to be allergic to fish . Suffering from the ‘fish‐chicken syndrome’, patients with concomitant fish and chicken allergy react to homologous proteins present in both meats . Chicken parvalbumin (Gal d 8), aldolase A (Gal d 10) and (beta‐)enolase (Gal d 9) have been recognized by specific IgE in 69%, 72% and 83% of 29 patients with concomitant fish and chicken allergy, respectively .…”

Section: Introductionmentioning

confidence: 99%

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Serum IgE cross‐reactivity between fish and chicken meats in dogs

Bexley

Kingswell

Olivry

2018

Veterinary Dermatology

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Background In humans, a cross‐reactive clinical allergy has been reported between three chicken and fish meat proteins: beta‐enolase, aldolase A and parvalbumin. Objective To evaluate if IgE cross‐reactivity between chicken and fish also existed in the dog. Animals Sera from dogs with suspected allergic skin disease and with IgE against chicken and fish. Methods and materials Sera were analysed by ELISA and immunoblotting with chicken, white fish (haddock and cod) and salmon extracts. Reciprocal inhibition ELISAs and inhibition immunoblots were then performed. Protein sequencing of bands identified on multiple extracts was determined by mass spectrometry. Results Out of 53 archived canine sera tested by ELISA against chicken, white fish or salmon, 15 (28%), 12 (23%) and 26 (49%), respectively, had elevated IgE against one, two or all three of these extracts. Seven of the triple‐reactive sera were subjected to reciprocal inhibition ELISAs. A >50% inhibition was found between chicken–fish, chicken–salmon and fish–salmon in seven, four and five of seven dogs, respectively. Immunoblotting identified multiple IgE‐binding proteins of identical molecular weights in the three extracts; these were partially to fully cross‐reactive by inhibition immunoblotting. Mass spectrometry identified nine cross‐reactive proteins as: pyruvate kinase, creatine kinase, alpha‐actin, glyceraldehyde‐3‐phosphate dehydrogenase, beta‐enolase, aldolase, malate dehydrogenase, lactate dehydrogenase and triose‐phosphate isomerase 1. All of these have been reported previously as fish, shellfish and/or chicken allergens for humans. Conclusions and clinical importance Whether any of these newly identified IgE cross‐reactive chicken–fish allergens is the cause of clinical allergy needs to be determined in dogs reacting to at least two of these common food sources.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Serum IgE cross‐reactivity between fish and chicken meats in dogs

Bexley

Kingswell

Olivry

2018

Veterinary Dermatology

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“…In contrast, only 2 of the 5 tested abundant S. mansoni proteins without allergenic homologues bound IgE. Interestingly, homologues of one of those IgE-binding antigens, aldolases, were recently described as cross-reactive allergens in fish and chicken meat [60]. …”

Section: Allergen Databasesmentioning

confidence: 99%

Navigating through the Jungle of Allergens: Features and Applications of Allergen Databases

Radauer

2017

Int Arch Allergy Immunol

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The increasing number of available data on allergenic proteins demanded the establishment of structured, freely accessible allergen databases. In this review article, features and applications of 6 of the most widely used allergen databases are discussed. The WHO/IUIS Allergen Nomenclature Database is the official resource of allergen designations. Allergome is the most comprehensive collection of data on allergens and allergen sources. AllergenOnline is aimed at providing a peer-reviewed database of allergen sequences for prediction of allergenicity of proteins, such as those planned to be inserted into genetically modified crops. The Structural Database of Allergenic Proteins (SDAP) provides a database of allergen sequences, structures, and epitopes linked to bioinformatics tools for sequence analysis and comparison. The Immune Epitope Database (IEDB) is the largest repository of T-cell, B-cell, and major histocompatibility complex protein epitopes including epitopes of allergens. AllFam classifies allergens into families of evolutionarily related proteins using definitions from the Pfam protein family database. These databases contain mostly overlapping data, but also show differences in terms of their targeted users, the criteria for including allergens, data shown for each allergen, and the availability of bioinformatics tools.

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“…Importantly cross-reactivity can occur between allergens from the same family like in nut allergens or in different species of house dust mite; but also, cross-reactivity could be present in diverse phylogenetic sources like house dust mite and shrimp, birch and apple, or fish and chicken meat ( Table 3) [38][39][40]. As we read in the previous section, technology innovation through recombinant allergens and full automatization notably reduce cross-reactivity risk when performing sIgE determinations.…”

Section: Limitations Of Sige Determinations: Allergen Cross-reactivitymentioning

confidence: 99%

Allergen-Based Diagnostic: Novel and Old Methodologies with New Approaches

Salazar¹,

Velázquez-Soto²,

Ayala-Balboa³

et al. 2017

Allergen

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This chapter is an extensive review of allergen-based diagnostic methodologies including old techniques such as skin prick test, radio-allergo sorbent test, enzymelinked immunosorbent assay, and fluorescent-enzyme immunosorbent assay. Novel technologies include functional tests by flow cytometry and molecular allergy based on multiplex immunoassays. We also review the importance of biochemical characteristics of allergens, sensitivity and specificity, cross-reaction between allergens, utility, reproducibility, interpretation, and methodologies for discovery of epitopes for diagnostic or therapeutic use.

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Cross‐reactivity to fish and chicken meat – a new clinical syndrome

Cited by 79 publications

References 30 publications

Serum IgE cross‐reactivity between fish and chicken meats in dogs

Serum IgE cross‐reactivity between fish and chicken meats in dogs

Navigating through the Jungle of Allergens: Features and Applications of Allergen Databases

Allergen-Based Diagnostic: Novel and Old Methodologies with New Approaches

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