Cross-reactive antigens and immunity to diseases caused by encapsulated bacteria

Robbins, John B.; Schneerson, Rachel; Glodé, Mary P.; Vann, Willie F.; Schiffer, Mark S.; Liu, Teh‐Yung; Parke, J. C.; Huntley, Carolyn C.

doi:10.1016/0091-6749(75)90119-0

Cited by 68 publications

(45 citation statements)

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“…It has been shown that the same V genes are used in antibody production against different bacterial and even autoantigens [33]. Effective protection against different pathogenic bacteria may be achieved by natural exposure to cross-reactive antigenic components of the normal human microflora [17,19]. Although we found high levels of antibodies binding to Hib CP in vitro, it remains to be determined if they are protective against Hib in vivo.…”

Section: Discussionmentioning

confidence: 66%

Expression of Haemophilus influenzae type b idiotype 1 on naturally acquired antibodies

Ulanova

Hahn-Zoric

Lau

et al. 1996

Clinical and Experimental Immunology

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SUMMARYThe Chinese population in Hong Kong has a low incidence of invasive Haemophilus influenzae type b (Hib) disease, as well as carriage of the microorganism. Likely stimuli for the natural antibodies to Hib, which might protect against Hib infection, are cross-reactive antigens of bacteria like Escherichia coli K100. Our aim was to determine the isotype and idiotype distribution and cross-reactivity of natural antibodies against Hib capsular polysaccharide (CP) in healthy Hong Kong Chinese. Titration of 20 sera by ELISA showed IgG antibodies reacting with Hib CP in all individuals. The antibodies were mainly IgG2, and their avidity index ranged widely. Isoelectric focusing (IEF) combined with immunoblotting showed patterns of IgG2 antibody clones against the CP of Hib and E. coli K100 which were similar in 10 cases. Absorption with Hib CP only eliminated some bands in two sera. Absorption with K100 CP did not remove any anti-Hib CP bands. In three sera additional clones of antibodies reacting to K100 CP only, disappeared after absorption with this CP. Spectrotypic analyses of IgG antibodies reacting with anti-Hib idiotype 1 (Id-1) revealed stronger IEF patterns with bands in differing locations compared with anti-Hib CP antibodies. The strong reactivity of serum IgG, IgA and IgM antibodies with monoclonal anti-Hib Id-1 was confirmed by ELISA. This reactivity was not abolished after absorption of the sera with either Hib CP, or K100 CP. The data indicate a high prevalence of Id-1 among Hong Kong Chinese. However, only one individual had Id-1 antibodies specific for Hib CP, judging from absorption experiments. Others had much lower activity of Id-1 anti-Hib CP antibodies compared with the total IgG Id-1, suggesting that Hong Kong subjects have Id-1-positive antibodies in their serum which are not specific for Hib CP. This is consistent with the nature of Id-1, which is a marker of A2V L region usage rather than a marker of a Hib CP paratope. We suggest that natural antibodies reacting with Hib CP in healthy Hong Kong Chinese are the product of exposure to some cross-reactive antigen(s), different from both Hib and E. coli K100 CP.

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Section: Discussionmentioning

confidence: 66%

Expression of Haemophilus influenzae type b idiotype 1 on naturally acquired antibodies

Ulanova

Hahn-Zoric

Lau

et al. 1996

Clinical and Experimental Immunology

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“…E. coli 0 75: K 100 fed to adult volunteers caused significant rises in anti-capsular antibodies, and the not infrequent occurrence of E. coli with the K 100 antigen might well explain the occurrence of antibodies to H. influenzae type b antigen in the adult population (Robbins et al 1973). Other examples of antigenic cross-reactions between coli K antigens and the capsular antigens of invasive bacteria have been described by Robbins et al (1974b).…”

Section: Role Of Adhesion For Experimental Infectionmentioning

confidence: 93%

“…However, at least one 0 group, 083, which is highly prevalent in continental Europe (Handriuck et al 1982;Mulder, van Alphen & Zanen, 1984), has only rarely been found in the U.S.A. Based on these results, it was natural to call the K 1 antigen a virulence factor. The K1 antigen and the capsular polysaccharide ofNeisseria meningitidis type B are chemically and immunologically E. coli in extra-intestinal infections 561 very similar (Grados & Ewing, 1970;Robbins et al 1974b): both are linear homopolymers of an a 2-8 linked N-acetyl neuraminic acid (NANA) (Barry & Goebel, 1957;Bolanos & de Witt, 1966). The K 1 antigen is a poor immunogen in rabbits when injected intravenously as live organisms.…”

Section: Role Of Adhesion For Experimental Infectionmentioning

confidence: 99%

“…The occurrence of the same capsular polysaccharide in two different pathogens causing bacterial meningitis, the coli K1 antigen and the group B antigen of N. meningitidis, has led to speculation about the importance of such cross-reacting antigens in 'natural immunity' to meningococcus B disease (Robbins et al 1974b). The common occurrence of K1 strains in the healthy intestine speaks for this possibility, while the poor immunogenicity of the K 1 antigen speaks against it (Robbins et al 1974b;0rskov et al 1979).…”

Section: Role Of Adhesion For Experimental Infectionmentioning

confidence: 99%

“…The common occurrence of K1 strains in the healthy intestine speaks for this possibility, while the poor immunogenicity of the K 1 antigen speaks against it (Robbins et al 1974b;0rskov et al 1979). Another pair of such cross-reacting antigens is the Haemophilus influenzae type b capsule and the coli K 100 antigen that are both polyribitol phosphates (Schneerson et al 1972;Robbins et al 1976).…”

Section: Role Of Adhesion For Experimental Infectionmentioning

confidence: 99%

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Ørskov

1985

J. Hyg.

220

161

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When Theodor Escherich (1885a, b) first describedEscherichia colihe looked on it as a saprophytic organism. Soon several investigators found that colibacteria could be isolated from intestinal infections and from many infections outside the intestine, like urinary tract infections (UTI), cholecystitis, wound infections, meningitis, septicaemia, pulmonary infections, and many more. Uhlenhuth (1897) showed that coli strains from pathological processes were more pathogenic in animal experiments than strains isolated from the normal intestine. Smith (1927), who examined strains from white scours in calves, showed that spontaneous acapsular mutants could be obtained from certain colibacteria, and that such mutants were less virulent when injected intra-peritoneally into guinea-pigs.

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Antibody levels to enteric bacteria in juvenile rheumatoid arthritis

Gutowska-Grzegorczyk

Baum

1977

Arthritis & Rheumatism

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In order to determine the immunologic status and possible susceptibility to bacterial infection in children with juvenile rheumatoid arthritis (JRA), titers of hemagglutinating antibodies to E coli 055, E coli 086, common antigen, and Shigella polyvalent antigen were measured. Immunoglobulin G was the predominant antibody. IgA antibodies were found in higher titers in children with J RA. No significant differences were found between children with JRA and matched controls. These data show that children with JRA do not have any deficit in antibody production to specific bacterial antigens, and any increased appearance of infection in these children is more probably due to deficiencies in cellular factors.An increased susceptibility to systemic and often fatal infections has been reported in both JRA and adult rheumatoid arthritis (1,2). However relatively little is

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Cross-reactive antigens and immunity to diseases caused by encapsulated bacteria

Cited by 68 publications

References 50 publications

Expression of Haemophilus influenzae type b idiotype 1 on naturally acquired antibodies

Expression of Haemophilus influenzae type b idiotype 1 on naturally acquired antibodies

Escherichia coliin extra-intestinal infections

Antibody levels to enteric bacteria in juvenile rheumatoid arthritis

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