Cross-Reactive Aeroallergens: Which Need to Cross Our Mind in Food Allergy Diagnosis?

Faber, Margaretha A.; Gasse, Athina L. Van; Decuyper, Ine I.; Sabato, Vito; Hagendorens, Margo M.; Mertens, Christel; Bridts, Chris H.; Clerck, Luc S. De; Ebo, Didier G.

doi:10.1016/j.jaip.2018.08.010

Cited by 43 publications

(37 citation statements)

References 154 publications

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“…6,7 Component resolved diagnostics have improved our ability to discriminate between PFAS and primary food allergy but are only of limited use in identifying patients with PFAS at risk of severe systemic reactions. 8,9 Whether prescription of epinephrine autoinjector devices is indicated in patients with PFAS remains unclear. 4,6,7 Is Food-Induced Anaphylaxis: Pathophysiologically Different Than Nonfood Anaphylaxis?…”

Section: Primary Ige-mediated Food Allergy Vs Pollen Food Allergy Synmentioning

confidence: 99%

Reaction phenotypes in IgE-mediated food allergy and anaphylaxis

Chong

Ruíz-García

Patel

et al. 2020

Annals of Allergy, Asthma & Immunology

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Food anaphylaxis may be pathophysiologically different than anaphylaxis caused by nonfood triggers. Currently, there are no robust, clinically useful predictors of severity in food allergy. It is likely that patient-specific reaction phenotypes exist in food allergy, which may affect the risk of severe anaphylaxis. Allergen immunotherapy may modulate these phenotypes. Machine-based learning may help with endotype discovery in anaphylaxis.

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Section: Primary Ige-mediated Food Allergy Vs Pollen Food Allergy Synmentioning

confidence: 99%

Reaction phenotypes in IgE-mediated food allergy and anaphylaxis

Chong

Ruíz-García

Patel

et al. 2020

Annals of Allergy, Asthma & Immunology

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“…[17][18][19] The exact explanation for these distinct clinical phenotypes remains unclear but could relate to differences in sensitization routes, the causative plant source (ripeness, cultivation conditions), inhibitory mechanisms, specific (s)IgG4 response and/or the affinity of sIgE antibodies as well as the presence of co-sensitization to other (plant) allergens. 20 In Southern Europe, nsLTP sensitization is believed to be predominantly governed by peach and its main allergen Pru p 3. It has been hypothesized that in this region, co-sensitization to pollen can modulate allergy severity.…”

Section: Introductionmentioning

confidence: 99%

Performance of basophil activation test and specific IgG4 as diagnostic tools in nonspecific lipid transfer protein allergy: Antwerp‐Barcelona comparison

Decuyper

Pascal

Gasse

et al. 2019

Allergy

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Background Recent studies show that nsLTP sensitization is not limited to the Mediterranean basin and can present diverse clinical phenotypes. It remains challenging to predict clinical outcome when specific IgE antibodies (sIgE) to nsLTPs are present. This study compares both clinical and in vitro allergy characteristics but also diagnostic performance of a basophil activation test (BAT) and sIgG4 in nsLTP‐sensitized patients from Antwerp (ANT, Belgium) and Barcelona (BCN, Spain). Methods Adult subjects with positive sIgE rPru p 3 and/or rMal d 3 ≥ 0.10 kUA/L (n = 182) and healthy controls (n = 37) were included. NsLTP‐sensitized individuals were stratified according to clinical symptoms with peach/apple, respectively. BAT rPru p 3 and rMal d 3 were performed and sIgG4 antibodies to both components quantified. Results In BCN, only ratios of sIgG4/sIgE rMal d 3 and BAT rMal d 3 (0.001 µg/mL) can identify clinically relevant Mal d 3 sensitization (sensitivity of 60%‐63% and a specificity of 75%‐67%, respectively). In ANT, only the sIgE/total IgE rPru p 3 ratio shows added value (sensitivity 60% and specificity 83%). Finally, it appears that symptomatic patients in BCN are more sensitive to lower allergen concentrations compared to ANT. In addition, it was shown that ANT patients were more often sensitized to pollen and that specific pollen sources differed between regions. Conclusions NsLTP‐related allergy profiles and diagnostic performance differ significantly between regions and are component‐specific, which makes extrapolation of data difficult to do. In addition, it seems that basophil sensitivity might show geographical differences. Additional research is needed to confirm these findings.

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“…Carbohydrate moieties present on the proteins may induce cross-reactivity reactions and thus named as cross-reactive CCD [42,43]. Cross-reactivity between sesame seeds and poppy seeds was found to be very high as shared epitopes have been recognized [44] as has been an evident case of cashew and pistachio [42,43]. Additionally, from serum IgE analysis, cross-reactivity has been also observed in pink peppercorn (Brazilian peppers) and cashew nut which was mediated partly by 2S albumin seed storage proteins [45].…”

Section: Spice Allergensmentioning

confidence: 99%

“…Additionally, from serum IgE analysis, cross-reactivity has been also observed in pink peppercorn (Brazilian peppers) and cashew nut which was mediated partly by 2S albumin seed storage proteins [45]. There are several types of proteinaceous allergens present in the spices like profilins, Betv1, CCD containing glycoproteins, germins, and pathogenesis-related proteins [43]. The Betv1 allergen family is structurally well defined and marked epitope conservation has been identified (Figure 3).…”

Section: Spice Allergensmentioning

confidence: 99%

Assessment of Occupational Health Hazards Due to Particulate Matter Originated from Spices

Upadhyay

Al-Mass

Dasgupta

et al. 2019

IJERPH

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Spices have been known for their various health activities; however, they also possess the allergic potential for the respiratory system and the skin as they are fine particulate matter. Persons involved in spice agriculture and food industries are at greater risk since they are exposed to a considerable amount of combustible dust, which may be the cause of fire and explosion and adversely affect the health. These workers may experience allergy, long-term and short-term respiratory issues including occupational asthma, dermatitis, etc. Some spices induce T cell-based inflammatory reaction upon contact recognition of the antigen. Antigen Presenting Cells (APC) on binding to the causative metabolite results in activation of macrophages by allergen cytokine interleukin (IL)-12 and tumor necrosis factor-beta (TNF). Cross-reactivity for protein allergens is another factor which seems to be a significant trigger for the stimulation of allergic reactions. Thus, it was imperative to perform a systematic review along with bioinformatics based representation of some evident allergens has been done to identify the overall conservation of epitopes. In the present manuscript, we have covered a multifold approach, i.e., to categorize the spice particles based on a clear understanding about nature, origin, mechanisms; to assess metabolic reactions of the particles after exposure as well as knowledge on the conditions of exposure along with associated potential health effects. Another aim of this study is to provide some suggestions to prevent and to control the exposure up to some extent.

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Cross-Reactive Aeroallergens: Which Need to Cross Our Mind in Food Allergy Diagnosis?

Cited by 43 publications

References 154 publications

Reaction phenotypes in IgE-mediated food allergy and anaphylaxis

Reaction phenotypes in IgE-mediated food allergy and anaphylaxis

Performance of basophil activation test and specific IgG4 as diagnostic tools in nonspecific lipid transfer protein allergy: Antwerp‐Barcelona comparison

Assessment of Occupational Health Hazards Due to Particulate Matter Originated from Spices

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