Cross-Reactions in the HLA System Revealed by Red Blood
Cells Expressing HLA Determinants, with Particular
Reference to Cross-Reaction between HLA-A2 and B17
Abstract:Sera with cytotoxic and haemagglutinating activity towards HLA-A2/28 were
also shown to react with red blood cells (RBC) expressing the HLA-B17 antigen determinant.
Absorption procedures with white blood cells (WBC) indicated that this was due to an
HLA-A2/B17 cross-reaction. Absorption experiments with some other sera which previously
had shown cytotoxic and haemagglutinating activity towards different HLA specificities,
revealed broad cross-reactions related to HLA-B locus antigens
“…The RBC antigens Bg a , Bg b , and Bg c correspond to HLA‐B7, HLA‐B17, and HLA‐A28, respectively 10,11 . HLA‐A2 antisera are strongly cross‐reactive with A28 antigens, and Bg c antisera are often found to bind to HLA‐A2 antigens 12 …”
“…The RBC antigens Bg a , Bg b , and Bg c correspond to HLA‐B7, HLA‐B17, and HLA‐A28, respectively 10,11 . HLA‐A2 antisera are strongly cross‐reactive with A28 antigens, and Bg c antisera are often found to bind to HLA‐A2 antigens 12 …”
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