Cross-Reactions in the HLA System Revealed by Red Blood Cells Expressing HLA Determinants, with Particular Reference to Cross-Reaction between HLA-A2 and B17

Abstract

Sera with cytotoxic and haemagglutinating activity towards HLA-A2/28 were also shown to react with red blood cells (RBC) expressing the HLA-B17 antigen determinant. Absorption procedures with white blood cells (WBC) indicated that this was due to an HLA-A2/B17 cross-reaction. Absorption experiments with some other sera which previously had shown cytotoxic and haemagglutinating activity towards different HLA specificities, revealed broad cross-reactions related to HLA-B locus antigens

Acute and delayed hemolytic transfusion reactions secondary to HLA alloimmunization

“…The RBC antigens Bg a , Bg b , and Bg c correspond to HLA‐B7, HLA‐B17, and HLA‐A28, respectively 10,11 . HLA‐A2 antisera are strongly cross‐reactive with A28 antigens, and Bg c antisera are often found to bind to HLA‐A2 antigens 12 …”