1993
DOI: 10.1093/infdis/167.6.1314
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Cross-Reacting Serum Opsonins to Meningococci after Vaccination

Abstract: The opsonic activity of sera from healthy volunteers immunized with an outer membrane vesicle vaccine prepared from a Neisseria meningitidis (class 3, 44/76, B:15:P1.7,16), characteristic of the present Norwegian epidemic, has been examined. A marked increase in the phagocytosis of class 3 and nontypeable strains of different serogroups, serotypes, and serosubtypes was demonstrated in the presence of postvaccination sera. Sera from vaccinees also caused a significant increase in leukocyte oxidative metabolism … Show more

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Cited by 20 publications
(16 citation statements)
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“…In addition, the influence of complement on this activity is a well-known phenomenon confirmed in this study. Opsonins against N. meningitidis B have also been reported by others (15,46). Opsonic activity was also detected in sera from subjects immunized with the Norwegian vaccine (1).…”
Section: Discussionsupporting
confidence: 57%
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“…In addition, the influence of complement on this activity is a well-known phenomenon confirmed in this study. Opsonins against N. meningitidis B have also been reported by others (15,46). Opsonic activity was also detected in sera from subjects immunized with the Norwegian vaccine (1).…”
Section: Discussionsupporting
confidence: 57%
“…The criteria are based on the necessity of close contact between IgG antibodies (the main antibody class that should be induced by an effective parenteral vaccine) in order to activate complement; the relative dispersion of outer membrane proteins on the bacterial surface; and the relative inaccessibility of these proteins, not only structural but also in the antigenic sense, created by a nonxenogenic capsular B polysaccharide (8,22,38). The IgG antibodies with bactericidal activity also have other important biological functions (e.g., as opsonins), and the induction of complement-fixing antibodies is more related to the Th1 pattern of cytokine production (15). This implies that other mechanisms could be present, such as IFN-␥-mediated phagocyte activation (28) in addition to bactericidal antibodies.…”
Section: Discussionmentioning
confidence: 99%
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“…In contrast, CL responses were obtained in the absence of C5. Responses of this kind have previ ously been shown to reflect phagocytosis [14], even though the correlation might not be entirely strict [30]. Judging from the lack of response following addition of Clq to heat-inactivated pooled normal human serum, PMNL Clq receptors [12,29] did not play an important role in our as say system.…”
Section: Discussionmentioning
confidence: 99%
“…Neisseria lactamica (Nlac) strain Y92-1009 [54] (a gift from A. Gorringe, HPA, Porton Down, Salisbury, UK) was originally isolated in Northern Ireland and is part of the ST-613 clonal complex, and N. meningitidis (Nme) strain H44/76 Δ1Δ4 [55] were grown on chocolate-agar plates containing 1% Isovitalex in a 37°C in a 5% CO 2 incubator. Murine B cells were isolated from C57Bl/6J mice and C3H/HeJ mice as previously described [31].…”
Section: Bacteria and Cell Culturesmentioning
confidence: 99%