Cross-Polarization Optical Coherence Tomography with Active Maintenance of the Circular Polarization of a Sounding Wave in a Common Path System

Gelikonov, Valentin M.; Romashov, Vladimir N.; Shabanov, Dmitry V.; Ksenofontov, S. Yu.; Терпелов, Д. А.; Shilyagin, Pavel A.; Gelikonov, Grigory V.; Vitkin, I. Alex

doi:10.1007/s11141-018-9856-9

Cited by 44 publications

(33 citation statements)

References 36 publications

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“…The system is based on the formation of the probe equivalent to a quarter-wave retarder plate with a 45° orientation of its optical axes with respect to the linearly polarized reference wave. This method was described in detail in a previous study 44 . Due to the use of active polarization control, the system is robust and does not require day-to-day maintenance.…”

Section: Methodsmentioning

confidence: 99%

Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

Yashin

Kiseleva

Moiseev

et al. 2019

Sci Rep

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Optical coherence tomography (OCT) is a promising method for detecting cancer margins during tumor resection. This study focused on differentiating tumorous from nontumorous tissues in human brain tissues using cross-polarization OCT (CP OCT). The study was performed on fresh ex vivo human brain tissues from 30 patients with high- and low-grade gliomas. Different tissue types that neurosurgeons should clearly distinguish during surgery, such as the cortex, white matter, necrosis and tumorous tissue, were separately analyzed. Based on volumetric CP OCT data, tumorous and normal brain tissue were differentiated using two optical coefficients — attenuation and forward cross-scattering. Compared with white matter, tumorous tissue without necrotic areas had significantly lower optical attenuation and forward cross-scattering values. The presence of particular morphological patterns, such as necrosis and injured myelinated fibers, can lead to dramatic changes in coefficient values and create some difficulties in differentiating between tissues. Color-coded CP OCT maps based on optical coefficients provided a visual assessment of the tissue. This study demonstrated the high translational potential of CP OCT in differentiating tumorous tissue from white matter. The clinical use of CP OCT during surgery in patients with gliomas could increase the extent of tumor resection and improve overall and progression-free survival.

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Section: Methodsmentioning

confidence: 99%

Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

Yashin

Kiseleva

Moiseev

et al. 2019

Sci Rep

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show abstract

“…27,28 The device is based on common-path autocorrelator scheme 29,30 and utilized cross-polarization reception channel. 31,32 It is approved for clinical use (product license No̱ FCP 2012/13479 of 30 May 2012) and has the following characteristics: the source of radiation is a superluminescent diode with a working wavelength of 1310 nm, a spectrum width of 100 nm, an axial resolution of 15 m, a lateral resolution of 25 m and a radiation power of 3 mW. 33 When scanning tissue at depth, a depth scattering pro¯le or A-scans of both co-and crosspolarizations are obtained.…”

Section: Cp Oct Studymentioning

confidence: 99%

In vivo assessment of structural changes of the urethra in lower urinary tract disease using cross-polarization optical coherence tomography

Kiseleva

Moiseev

Kuyarov

et al. 2020

J. Innov. Opt. Health Sci.

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The paper presents the results of a study of the female urethra in cases of urethral pain syndrome (UPS) and inflammatory diseases of the lower urinary tract using cross-polarization optical coherence tomography (CP OCT). Urethral wall structure was studied in 86 patients; 233 CP OCT images were collected. A comparative qualitative analysis of three groups of CP OCT images — “norm”, “Inflammation” and “UPS” — identified that despite the absence of a clear inflammatory factor in the patient’s examination, the urethral tissues in UPS were in an altered state. The changes in the urethral wall with UPS and in cases of inflammation were similar. Using a point scale, three experts independently performed visual scoring of the CP OCT images. Three parameters: epithelial contrast, cavities and the minimum signal depth in the co-channel were evaluated. It was found that, individually, the parameters correlate only weakly with the diagnosis. Area under the receiver operating characteristic (ROC) curve was from 0.51 to 0.78. The joint use of a number of visual signs has a greater diagnostic value than the use of the criteria individually. Area under the ROC curve using the developed cumulative criterion reached up to 0.87–0.89. This study could form the basis of a scoring system for assessing the state of the urethral tract using CP OCT images in real time. The CP OCT method provides information on the state of urethral tissues that cannot be obtained with traditional cystoscopy.

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“…A spectral domain CP OCT device (Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russia) with cross-polarization detection was used in the study. 32,33 The central wavelength of this device is 1310 nm with a radiation power of 20 mW. The axial resolution is 10 μm and the lateral resolution is 15 μm in air.…”

Section: Cp Oct Devicementioning

confidence: 99%

Optical coefficients as tools for increasing the optical coherence tomography contrast for normal brain visualization and glioblastoma detection

et al. 2019

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Cross-Polarization Optical Coherence Tomography with Active Maintenance of the Circular Polarization of a Sounding Wave in a Common Path System

Cited by 44 publications

References 36 publications

Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

In vivo assessment of structural changes of the urethra in lower urinary tract disease using cross-polarization optical coherence tomography

Optical coefficients as tools for increasing the optical coherence tomography contrast for normal brain visualization and glioblastoma detection

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