Cross-polarization OCT needle probe for combined blood vessels detection and tissue differentiation during stereotactic biopsy of brain tumors

Kiseleva, Elena B.; Shilyagin, Pavel A.; Romashov, Vladimir N.; Korzhimanova, Yulia V.; Sirotkina, Marina A.; Yashin, Konstantin; Zagaynova, Elena V.; Gelikonov, Grigory V.; Gladkova, Natalia D.

doi:10.1117/12.2526770

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…The OCT probe can be integrated into a standard biopsy needle, allowing for the precise monitoring of needle placement and immediate tissue analysis in the biopsy area. Such advancements in stereotactic OCT probes have the potential to make procedures safer, more accurate, and less invasive [ 90 ].…”

Section: Diagnostic Toolsmentioning

confidence: 99%

“…While the initial image assessment relied on visual criteria, the study highlighted the potential for heightened sensitivity and specificity in differentiating tissue types and detecting blood vessels through the implementation of CP OCT signal quantification methods. In summary, this research underscored the potential of CP OCT as an effective tool for guiding OCT-assisted stereotactic brain tumor biopsies, offering the promise of improving the precision and safety of these neurosurgical procedures [ 90 ].…”

Section: Diagnostic Toolsmentioning

confidence: 99%

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Advances in Diagnostic Tools and Therapeutic Approaches for Gliomas: A Comprehensive Review

Thenuwara,

Curtin,

Tian

2023

Sensors

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Gliomas, a prevalent category of primary malignant brain tumors, pose formidable clinical challenges due to their invasive nature and limited treatment options. The current therapeutic landscape for gliomas is constrained by a “one-size-fits-all” paradigm, significantly restricting treatment efficacy. Despite the implementation of multimodal therapeutic strategies, survival rates remain disheartening. The conventional treatment approach, involving surgical resection, radiation, and chemotherapy, grapples with substantial limitations, particularly in addressing the invasive nature of gliomas. Conventional diagnostic tools, including computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET), play pivotal roles in outlining tumor characteristics. However, they face limitations, such as poor biological specificity and challenges in distinguishing active tumor regions. The ongoing development of diagnostic tools and therapeutic approaches represents a multifaceted and promising frontier in the battle against this challenging brain tumor. The aim of this comprehensive review is to address recent advances in diagnostic tools and therapeutic approaches for gliomas. These innovations aim to minimize invasiveness while enabling the precise, multimodal targeting of localized gliomas. Researchers are actively developing new diagnostic tools, such as colorimetric techniques, electrochemical biosensors, optical coherence tomography, reflectometric interference spectroscopy, surface-enhanced Raman spectroscopy, and optical biosensors. These tools aim to regulate tumor progression and develop precise treatment methods for gliomas. Recent technological advancements, coupled with bioelectronic sensors, open avenues for new therapeutic modalities, minimizing invasiveness and enabling multimodal targeting with unprecedented precision. The next generation of multimodal therapeutic strategies holds potential for precision medicine, aiding the early detection and effective management of solid brain tumors. These innovations offer promise in adopting precision medicine methodologies, enabling early disease detection, and improving solid brain tumor management. This review comprehensively recognizes the critical role of pioneering therapeutic interventions, holding significant potential to revolutionize brain tumor therapeutics.

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Section: Diagnostic Toolsmentioning

confidence: 99%

Section: Diagnostic Toolsmentioning

confidence: 99%

Advances in Diagnostic Tools and Therapeutic Approaches for Gliomas: A Comprehensive Review

Thenuwara,

Curtin,

Tian

2023

Sensors

View full text Add to dashboard Cite

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“…Recently suggested stereotactic OCT probes for intraoperative optical biopsy and blood vessel detection allow enhancing the accuracy and safety of the procedure by solving the following problems—visualization of blood vessels in the biopsy area and identification of tumorous tissue [ 92 ] ( Figure 6 ). This will allow avoiding intraoperative histopathological examination of tissue and avoiding the occurrence of intracerebral hemorrhages.…”

Section: Oct For Stereotactic Biopsymentioning

confidence: 99%

OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives

et al. 2022

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Optical coherence tomography (OCT) has been recently suggested as a promising method to obtain in vivo and real-time high-resolution images of tissue structure in brain tumor surgery. This review focuses on the basics of OCT imaging, types of OCT images and currently suggested OCT scanner devices and the results of their application in neurosurgery. OCT can assist in achieving intraoperative precision identification of tumor infiltration within surrounding brain parenchyma by using qualitative or quantitative OCT image analysis of scanned tissue. OCT is able to identify tumorous tissue and blood vessels detection during stereotactic biopsy procedures. The combination of OCT with traditional imaging such as MRI, ultrasound and 5-ALA fluorescence has the potential to increase the safety and accuracy of the resection. OCT can improve the extent of resection by offering the direct visualization of tumor with cellular resolution when using microscopic OCT contact probes. The theranostic implementation of OCT as a part of intelligent optical diagnosis and automated lesion localization and ablation could achieve high precision, automation and intelligence in brain tumor surgery. We present this review for the increase of knowledge and formation of critical opinion in the field of OCT implementation in brain tumor surgery.

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Cross-polarization OCT needle probe for combined blood vessels detection and tissue differentiation during stereotactic biopsy of brain tumors

Cited by 2 publications

References 8 publications

Advances in Diagnostic Tools and Therapeutic Approaches for Gliomas: A Comprehensive Review

Advances in Diagnostic Tools and Therapeutic Approaches for Gliomas: A Comprehensive Review

OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives

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