2012
DOI: 10.1590/s1678-91992012000100015
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Abstract: Cross-neutralization of Crotalus durissus terrificus venom coagulant activity was tested using bivalent horse antivenom against Bothrops alternatus and Bothrops diporus venoms. Our in vitro and in vivo experiments showed that bothropic antivenom neutralizes the thrombin-like activity of crotalic snake venom and this cross-reaction was demonstrated by immunoassays either with whole venom or a purified thrombin-like enzyme. These results suggest common antigenic properties and, consequently, similar molecular st… Show more

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Cited by 10 publications
(2 citation statements)
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References 15 publications
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“…The plates were washed and processed as described by 256 (Rodríguez et al, 2012). Absorbance was read at 490 nm with a Multiskan® EX (Thermo 257 Scientific, USA) multiwell plate reader.…”
Section: Elisa and Dot Blotting Tests 254mentioning
confidence: 99%
“…The plates were washed and processed as described by 256 (Rodríguez et al, 2012). Absorbance was read at 490 nm with a Multiskan® EX (Thermo 257 Scientific, USA) multiwell plate reader.…”
Section: Elisa and Dot Blotting Tests 254mentioning
confidence: 99%
“…This mixture exhibits values of specific proteolytic activity and MiHD sufficient for use as a sensitizing agent for antiserum manufacturing. This will contribute to the obtainment of more specific anti-sera and therefore the avoidance of adverse effects (40). The presence of a low PEG concentration (close to 3 % w/w) in the bottom phase does not represent a disadvantage since this polymer possesses a low immunogenic capability (41).…”
Section: Phospholipase a 2 And Protease Separationmentioning
confidence: 99%