This article takes its point of departure in the rapidly expanding field of research focusing on governance of large and complex systems and argues that this research should more explicitly recognize ongoing theoretical debates within contemporary and more mainstream governance research in order to fulfill all of its potential. This includes explicitly recognizing the fundamental and inherently political nature of governance as well as the potential contributions to be made from incorporating more of institutional theory in governance research. In addition, the article shows how research on large, complex systems can inform existing research on governance and institutional theory. Recent research on governance of large and complex systems could, for example, help governance research regain its relevance by explicitly focusing on the "big questions." Focusing on large and complex systems is certainly of paramount real-world importance, but it also highlights theoretical and empirical puzzles at the core of traditional disciplines such as political science or economics. Finally, the explicit systems perspective with its focus on nonlinearity and limited predictability could also help institutional theory move away from its underlying assumptions about functionalism and voluntarism and could, as such, contribute to existing research on institutional creation, reproduction, and change.