Cross‐modal generality of the gating deficit

Edgar, J. Christopher; Miller, Gregory A.; Moses, Sandra N.; Thoma, Robert J.; Huang, Mingxiong; Hanlon, Faith M.; Weisend, Michael P.; Sherwood, Andrea R.; Bustillo, Juan; Adler, Larry; Cañive, José M.

doi:10.1111/j.1469-8986.2005.00292.x

Cited by 32 publications

(21 citation statements)

References 63 publications

(87 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypo-activation in S1 and M1 at later latencies in schizophrenic patients may be explained by the reduced interaction between primary sensorimotor areas and higher-order somatosensory and motor processing areas such as S2 and dPMA, in which hypoactivation was persistent in both hemispheres across all latencies. Finally, it is worth noting that present findings are consistent with other somatosensory studies observing intact early M20 somatosensory activity (Edgar et al 2005) but impaired secondary somatosensory cortex activity at ~80 ms (Thoma et al 2007) in patients with schizophrenia.…”

Section: Discussionsupporting

confidence: 92%

Somatosensory System Deficits in Schizophrenia Revealed by MEG during a Median-Nerve Oddball Task

et al. 2009

Self Cite

View full text Add to dashboard Cite

Although impairments related to somatosensory perception are common in schizophrenia, they have rarely been examined in functional imaging studies. In the present study, magnetoencephalography (MEG) was used to identify neural networks that support attention to somatosensory stimuli in healthy adults and abnormalities in these networks in patient with schizophrenia. A median-nerve oddball task was used to probe attention to somatosensory stimuli, and an advanced, high-resolution MEG source-imaging method was applied to assess activity throughout the brain. In nineteen healthy subjects, attention-related activation was seen in a sensorimotor network involving primary somatosensory (S1), secondary somatosensory (S2), primary motor (M1), pre-motor (PMA), and paracentral lobule (PCL) areas. A frontal–parietal–temporal “attention network”, containing dorsal- and ventral–lateral prefrontal cortex (DLPFC and VLPFC), orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), superior parietal lobule (SPL), inferior parietal lobule (IPL)/supramarginal gyrus (SMG), and temporal lobe areas, was also activated. Seventeen individuals with schizophrenia showed early attention-related hyperactivations in S1 and M1 but hypo-activation in S1, S2, M1, and PMA at later latency in the sensorimotor network. Within this attention network, hypoactivation was found in SPL, DLPFC, orbitofrontal cortex, and the dorsal aspect of ACC. Hyperactivation was seen in SMG/IPL, frontal pole, and the ventral aspect of ACC in patients. These findings link attention-related somatosensory deficits to dysfunction in both sensorimotor and frontal–parietal–temporal networks in schizophrenia.

show abstract

Section: Discussionsupporting

confidence: 92%

Somatosensory System Deficits in Schizophrenia Revealed by MEG during a Median-Nerve Oddball Task

et al. 2009

Self Cite

View full text Add to dashboard Cite

show abstract

“…MEG studies have replicated the well-known pattern of fronto-temporal low-frequency activity observed in EEC, and have also demonstrated abnormal sensory gating and basic cognitive processing (Canive et al, 1996;Kissler et al, 2000;Fehr et al, 2003;Wienbruch et al, 2003;Edgar et al, 2005;Lopez-Ibor et al, 2008;Naatanen and Kahkonen, 2009). A further step in this research is non-linear dynamics analysis (NDA).…”

Section: Introductionmentioning

confidence: 80%

Lempel–Ziv complexity in schizophrenia: A MEG study

Fernández

López‐Ibor

Turrero

et al. 2011

Clinical Neurophysiology

View full text Add to dashboard Cite

SchizophreniaLempel-Ziv complexity Magnetoencephalography Neurodevelopmental Neurodegenerative• Schizophrenic patients show higher complexity values as compared to controls.• Schizophrenic patients showed a tendency to reduced complexity values as a function of age while controls showed the opposite tendency.• The tendency observed in schizophrenic patients parallels the tendency observed in Alzheimer disease patients. ABSTRACTObjective: The neurodevelopmental-neurodegenerative debate is a basic issue in the field of the neuropathological basis of schizophrenia (SCH). Neurophysiological techniques have been scarcely involved in such debate, but nonlinear analysis methods may contribute to it. Methods: Fifteen patients (age range 23-42 years) matching DSM IV-TR criteria for SCH, and 15 sex-and age-matched control subjects (age range 23-42 years) underwent a resting-state magnetoencephalographic evaluation and Lempel-Ziv complexity (LZC) scores were calculated. Results: Regression analyses indicated that LZC values were strongly dependent on age. Complexity scores increased as a function of age in controls, while SCH patients exhibited a progressive reduction of LZC values. A logistic model including LZC scores, age and the interaction of both variables allowed the classification of patients and controls with high sensitivity and specificity. Conclusions: Results demonstrated that SCH patients failed to follow the "normal" process of complexity increase as a function of age. In addition, SCH patients exhibited a significant reduction of complexity scores as a function of age, thus paralleling the pattern observed in neurodegenerative diseases. Significance: Our results support the notion of a progressive defect in SCH, which does not contradict the existence of a basic neurodevelopmental alteration.

show abstract

“…Second, we used strictly monaural stimulation for each ear separately so as not to induce cross-hearing. Most P50m suppression studies involve binaural stimulations or stimulations at a high sound pressure level to induce cross-hearing (Thoma et al, 2003(Thoma et al, , 2004Edgar et al, 2003Edgar et al, , 2005Lu et al, 2007;Weiland et al, 2008;Hirano et al, 2008Hirano et al, , 2010. Third, since it is well known that P50 is affected by vigilance (Cullum et al, 1993), we used silent movies to keep the subjects awake.…”

Section: Pws Cannot "Gate Out"mentioning

confidence: 98%

Spatiotemporal signatures of an abnormal auditory system in stuttering

et al. 2011

View full text Add to dashboard Cite

People who stutter (PWS) can reduce their stuttering rates under masking noise and altered auditory feedback; such a response can be attributed to altered auditory input, which suggests that abnormal speech processing in PWS results from abnormal processing of auditory input. However, the details of this abnormal processing of basic auditory information remain unclear. In order to characterize such abnormalities, we examined the functional and structural changes in the auditory cortices of PWS by using a 306-channel magnetoencephalography system to assess auditory sensory gating (P50m suppression) and tonotopic organization. Additionally, we employed voxel-based morphometry to compare cortical gray matter (GM) volumes on structural MR images. PWS exhibited impaired left auditory sensory gating. The tonotopic organization in the right hemisphere of PWS is expanded compared with that of the controls. Furthermore, PWS showed a significant increase in the GM volume of the right superior temporal gyrus, consistent with the right tonotopic expansion. Accordingly, we suggest that PWS have impaired left auditory sensory gating during basic auditory input processing and that some error signals in the auditory cortex could result in abnormal speech processing. Functional and structural reorganization of the right auditory cortex appears to be a compensatory mechanism for impaired left auditory cortex function in PWS.

show abstract

Cross‐modal generality of the gating deficit

Cited by 32 publications

References 63 publications

Somatosensory System Deficits in Schizophrenia Revealed by MEG during a Median-Nerve Oddball Task

Somatosensory System Deficits in Schizophrenia Revealed by MEG during a Median-Nerve Oddball Task

Lempel–Ziv complexity in schizophrenia: A MEG study

Spatiotemporal signatures of an abnormal auditory system in stuttering

Contact Info

Product

Resources

About