Cross-linking of highly methoxylated pectin with copper: the specific anion influence

Šešlija, Sanja I.; Veljović, Djordje; Krušić, Melina Kalagasidis; Stevanović, Jasmina S.; Veličković, Suzana; Popović, Ivanka G.

doi:10.1039/c5nj03320a

Cited by 25 publications

(12 citation statements)

References 43 publications

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“…4). The broad band appeared at 3429 cm -1 in the spectra corresponds to the OH groups due to hydrogen intra-and intermolecular hydrogen bonding of pectin (Seslija et al 2016). The presence of alkyl group was observed by the existence of peak at 2921 cm -1 .…”

Section: Characterizationmentioning

confidence: 91%

Pectin from muskmelon (Cucumis melo var. reticulatus) peels: extraction optimization and physicochemical properties

Chandrasekaran¹,

Banupriya²,

Harinee³

et al. 2017

3 Biotech

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Pectin derived from plant waste sources is currently focused as an economical and eco-friendly approach. Optimization of pectin extraction from muskmelon peel by response surface methodology (RSM) was investigated in this study. Box-Behnken Design (BBD) was used to identify the optimal level of the extraction variables such as time, pH and temperature. A second-order model equation for pectin extraction was obtained from multiple regression analysis of experimental data with the correlation coefficient (R 2 ) value of 0.92. ANOVA results showed that linear effect of temperature and combined effect of pH with temperature were found significant for pectin extraction from muskmelon peel. Validation results had good agreement with the predicted results. Pectin extracted from muskmelon peel was classed as high methoxy pectin with the equivalent weight of 384.5 g/mol. Non-newtonian pseudoplastic flow behaviour was observed for muskmelon pectin from the viscosity studies.

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Section: Characterizationmentioning

confidence: 91%

Pectin from muskmelon (Cucumis melo var. reticulatus) peels: extraction optimization and physicochemical properties

Chandrasekaran¹,

Banupriya²,

Harinee³

et al. 2017

3 Biotech

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“…55 , and CH 3 COO −1 were used for crosslinking process of highly methoxylated pectin and copper concentration was measured in solution during crosslinking. al.…”

Section: In Vitro Release Studiesmentioning

confidence: 99%

“…al. 55 , and CH 3 COO −1 were used for crosslinking process of highly methoxylated pectin and copper concentration was measured in solution during crosslinking. They found that the anions affected the sorption capacity which implied greater/smaller exhaustion of the copper ions involved in the crosslinking process.…”

Section: In Vitro Release Studiesmentioning

confidence: 99%

Theophylline‐loaded pectin‐based hydrogels. II. Effect of concentration of initial pectin solution, crosslinker type and cation concentration of external solution on drug release profile

Sarioglu

Kocaaga

Turan

et al. 2019

J of Applied Polymer Sci

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A series of drug-loaded pectin hydrogels were prepared by mixing method in two ion types, Ca +2 or Zn +2 , for wound dressing applications and their drug release performances were investigated at pH 6.4 in four different calcium ion concentrations of external solution. Pectin hydrogels were synthesized in three different concentrations of initial pectin solution and theophylline was used as a model drug. Fourier transform infrared spectroscopy, scanning electron microscopy, and atomic force microscopy were used for hydrogel characterization. Additionally, fluid handling capacity, swelling behavior, dehydration rate, dispersion characteristic, dressing pH determination, water vapor permeability, oxygen permeability, surface contact angle, flexibility, mass per unit area, and thickness were determined for selected hydrogels. One of the most valuable contributions of our study is that the concentration of initial pectin solution and calcium ion concentration of external solution are very important parameters to obtain an effective drug release. After evaluating all data, we have shown that flexible and transparent pectin-based wound dressings can be synthesized as a controlled drug release system. Zinc-containing hydrogel was antibacterial against Staphylococcus aureus and Escherichia coli but not suitable for cell migration. On the other hand, calcium-based hydrogel was nontoxic on the fibroblast cells and it had no negative effect on cell migration.

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“…Pectin consists of a long chain polysaccharide with D-galacturonic acid as its monomer which resides in an alpha-(1-4) chain. As a polysaccharide, it has a broad carboxylic O-H stretch from 3500 to 2400 cm −1 , a carbonyl C=O stretch at 1710 cm −1 , an asymmetric and symmetric carboxylic anionic vibration at 1637 cm −1 and 1549 cm −1 , a C-OH (carboxylic, ester, and alcoholic) stretch at 1047 cm −1 [ 32 ], and 1200–800 cm −1 for carbohydrates and in the fingerprint region.…”

Section: Resultsmentioning

confidence: 99%

In Vitro Evaluation of Cocoa Pod Husk Pectin as a Carrier for Chronodelivery of Hydrocortisone Intended for Adrenal Insufficiency

Adi-Dako

Ofori-Kwakye

Boakye-Gyasi

et al. 2017

Journal of Drug Delivery

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This study evaluated the in vitro potential of cocoa pod husk (CPH) pectin as a carrier for chronodelivery of hydrocortisone intended for adrenal insufficiency. FTIR studies found no drug-CPH pectin interactions, and chemometric analysis showed that pure hydrocortisone bears closer similarity to hydrocortisone in hot water soluble pectin (HWSP) than hydrocortisone in citric acid soluble pectin (CASP). CPH pectin-based hydrocortisone matrix tablets (~300 mg) were prepared by direct compression and wet granulation techniques, and the tablet cores were film-coated with a 15% HPMC formulation for timed release, followed by a 12.5% Eudragit® S100 formulation for acid resistance. In vitro drug release studies of the uncoated and coated matrix tablets in simulated gastrointestinal conditions showed that wet granulation tablets exhibit greater retardation of drug release in aqueous medium than directly compressed tablets. CASP showed greater suppression of drug release in aqueous medium than HWSP. Wet granulation HWSP-based matrix tablets coated to a final coat weight gain of ~25% w/w were optimized for chronodelivery of hydrocortisone in the colon. The optimized tablets exhibited a lag phase of ~6 h followed by accelerated drug release in the colonic region and have potential to control night time cortisol levels in patients with adrenal insufficiency.

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Cross-linking of highly methoxylated pectin with copper: the specific anion influence

Abstract: Highly methoxylated pectin was cross-linked using different copper salts. The dependence between anion type, sorption capacity, mechanical and structural properties of obtained beads was found and correlated with Hofmeister theory.

Cited by 25 publications

References 43 publications

Pectin from muskmelon (Cucumis melo var. reticulatus) peels: extraction optimization and physicochemical properties

Pectin from muskmelon (Cucumis melo var. reticulatus) peels: extraction optimization and physicochemical properties

Theophylline‐loaded pectin‐based hydrogels. II. Effect of concentration of initial pectin solution, crosslinker type and cation concentration of external solution on drug release profile

In Vitro Evaluation of Cocoa Pod Husk Pectin as a Carrier for Chronodelivery of Hydrocortisone Intended for Adrenal Insufficiency

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