Cross‐Linked Pseudopeptides via Pd‐Catalyzed Carbonylative Coupling of α‐Amino Acid Iodides with α‐Amino Acid Esters in the Presence of a CO Surrogate

Rathod, Gajanan K.; Jain, Rahul

doi:10.1002/ejoc.202301010

Cited by 2 publications

(1 citation statement)

References 56 publications

(26 reference statements)

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“…The products were highly enantioselective and formed at milder conditions of 80 °C in 35 min. They were the first to explain the regioselectivity of histidine [141] …”

Section: Microwave‐assisted Carbonylationsmentioning

confidence: 99%

A Review of Synthetic Application of Homogeneous, Heterogenised‐Homogeneous, and Microwave‐Assisted Catalytic Carbonylation of Selected Substrates

Pant,

Prakash,

Dhami

2024

ChemistrySelect

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Catalytic carbonylation has gained a lot of interest over the past 20 years. It produced various pharmaceuticals, agrochemicals, and intermediates that can made through this process. The carbonylation process is the most straightforward method to insert CO into any organic substrate using a simple carbonyl source, i. e., CO gas. Apart from gaseous CO, many techniques have devised for producing CO in situ using surrogates such as HCOOH, DMF, Formic acid, Phenyl Formate, Oxalic acid, and Chloroform. Several carbonylation methods, such as aminocarbonylation, alkoxycarbonylation, double carbonylation, and oxidative carbonylation, provide viable and appealing substitutes for conventional synthetic methods on a commercial or laboratory scale. Many recent studies focus on catalyst‐product separation, catalyst recoverability, and reusability in these reactions. Therefore, advancements in using different approaches, such as supported liquid phase catalysis and biphasic catalysis, to anchor homogeneous catalysts are becoming increasingly important. These carbonylation methods are easy to use, cost‐effective, and do not require ligands. They also produce excellent yields of the products necessary. Using phosphine ligands has drawbacks, including high work‐up costs, laborious work‐up techniques, and sensitivity to air and moisture. Several phosphine‐free carbonylation pathways offer affordable and straightforward ways to accomplish these changes without phosphine ligands. This review summarizes the synthetic application of homogeneous and immobilized catalysts in producing carboxylic acid derivatives and heterocycles that have medicinal properties.

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“…The products were highly enantioselective and formed at milder conditions of 80 °C in 35 min. They were the first to explain the regioselectivity of histidine [141] …”

Section: Microwave‐assisted Carbonylationsmentioning

confidence: 99%

A Review of Synthetic Application of Homogeneous, Heterogenised‐Homogeneous, and Microwave‐Assisted Catalytic Carbonylation of Selected Substrates

Pant,

Prakash,

Dhami

2024

ChemistrySelect

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Synthesis of Cross-Linked Pseudopeptides Using Pd-Catalyzed Carbonylative Coupling

2024

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Cross‐Linked Pseudopeptides via Pd‐Catalyzed Carbonylative Coupling of α‐Amino Acid Iodides with α‐Amino Acid Esters in the Presence of a CO Surrogate

Cited by 2 publications

References 56 publications

A Review of Synthetic Application of Homogeneous, Heterogenised‐Homogeneous, and Microwave‐Assisted Catalytic Carbonylation of Selected Substrates

A Review of Synthetic Application of Homogeneous, Heterogenised‐Homogeneous, and Microwave‐Assisted Catalytic Carbonylation of Selected Substrates

Synthesis of Cross-Linked Pseudopeptides Using Pd-Catalyzed Carbonylative Coupling

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