Cross‐Linkable Polyion Complex Micelles from Polypept(o)ide‐Based ABC‐Triblock Copolymers for siRNA Delivery

Capelôa, Leon; Yazdi, Mina; Zhang, Heyang; Chen, Xiaobing; Nie, Yu; Wagner, Ernst; Lächelt, Ulrich; Barz, Matthias

doi:10.1002/marc.202100698

Cited by 9 publications

(3 citation statements)

References 54 publications

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“…Polymers generally investigated for gene delivery are also studied for the development of PMs for siRNA. Some of the most explored synthetic polymers since early studies are PEI [ 231 , 232 ], PLL [ 233 ], poly(amido amine) [ 234 , 235 ] and PCL [ 137 , 149 ]. Furthermore, pH-responsive polymers are also widely explored for the rational design of PMs for siRNAs [ 236 , 237 ].…”

Section: Polymeric Micelles For Nucleic Acid Deliverymentioning

confidence: 99%

Polymeric-Micelle-Based Delivery Systems for Nucleic Acids

et al. 2023

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Nucleic acids can modulate gene expression specifically. They are increasingly being utilized and show huge potential for the prevention or treatment of various diseases. However, the clinical translation of nucleic acids faces many challenges due to their rapid clearance after administration, low stability in physiological fluids and limited cellular uptake, which is associated with an inability to reach the intracellular target site and poor efficacy. For many years, tremendous efforts have been made to design appropriate delivery systems that enable the safe and effective delivery of nucleic acids at the target site to achieve high therapeutic outcomes. Among the different delivery platforms investigated, polymeric micelles have emerged as suitable delivery vehicles due to the versatility of their structures and the possibility to tailor their composition for overcoming extracellular and intracellular barriers, thus enhancing therapeutic efficacy. Many strategies, such as the addition of stimuli-sensitive groups or specific ligands, can be used to facilitate the delivery of various nucleic acids and improve targeting and accumulation at the site of action while protecting nucleic acids from degradation and promoting their cellular uptake. Furthermore, polymeric micelles can be used to deliver both chemotherapeutic drugs and nucleic acid therapeutics simultaneously to achieve synergistic combination treatment. This review focuses on the design approaches and current developments in polymeric micelles for the delivery of nucleic acids. The different preparation methods and characteristic features of polymeric micelles are covered. The current state of the art of polymeric micelles as carriers for nucleic acids is discussed while highlighting the delivery challenges of nucleic acids and how to overcome them and how to improve the safety and efficacy of nucleic acids after local or systemic administration.

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Section: Polymeric Micelles For Nucleic Acid Deliverymentioning

confidence: 99%

Polymeric-Micelle-Based Delivery Systems for Nucleic Acids

et al. 2023

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“…Um zum Beispiel den unerwünschten Abbau von siRNA zu verhindern, entwickelten Barz und Team Poly ionmizellen aus Polypeptidtriblockcopolymeren, die siRNA transportieren. 29)…”

Section: Biomedizinische Materialienunclassified

Trendbericht: Makromolekulare Chemie 2023

Göstl

2023

Nachr Chem

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“…[1][2][3] Synthetic polypeptides, as the analogues of natural proteins, are emerging biomimetic materials owing to their ability to not only form a stable α-helix, but also achieve structural diversity via introducing versatile unnatural components. [4][5][6][7] To date, synthetic polypeptides have been extensively used in cell penetration, 8,9 drug/gene delivery, [10][11][12][13][14] antibacterial agents [15][16][17][18][19] and tissue engineering. 20,21 Ring opening polymerization (ROP) of an N-carboxyanhydride (NCA) monomer has been developed as a facile method to prepare high molecular weight and multi-functional polypeptides with α-helical structures.…”

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confidence: 99%