Cross-immunity among Syngeneic Tumors of Mice

Usubuchi, Isamu; Sobajima, Yukio; Kudo, Hiroto; Hongo, Toshiro; Sugawara, Masashiro

doi:10.1620/tjem.108.79

Cited by 6 publications

(6 citation statements)

References 9 publications

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“…Some investigators described cross-immunity between chemicallyinduced tumors by in vivo transplantation rejection methods as well as in vitro methods (Parmiani and Invernizzi 1975;Leffell and Coggin 1977;Hellstrom et al 1978;Cleveland et al 1979). In the previous paper, we reported cross-immunity among mammary carcinomas and 3-methylcholanthrene (MCA)-induced sarcomas in C3H/He mice by immunization with viable tumor cells (Usubuchi et al 1972b). Our findings were different from the results obtained so far.…”

contrasting

confidence: 99%

Cross-immunity between syngeneic tumors in mice immunized with gamma-irradiated ascites tumors.

Kudo¹,

Waga²,

Sato³

et al. 1980

Tohoku J. Exp. Med.

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, 1980, 131 (3), 285-288 -C3H/He mice immunized repeatedly with irradiated (13,000 rads 6OCo) MM46 or MM48, both transplantable ascites mammary carcinomas of the same strain, were subcutaneously challenged with the identical or the different tumor. In mice immunized with irradiated MM46, the growth of challenges of not only MM46 but also MM48 was inhibited.On the other hand, in mice immunized with irradiated MM48, the growth of challenges of MM48 was inhibited, but the inhibition of the growth of MM46 was not observed.Corss-immunity, therefore, was shown by immunization with MM46 but not with MM48. These findings were considered to indicate that MM46 expressed cross-immunity against MM48 because of its high resistance to the irradiation, and that MM48 did not show cross-immunity to MM46 because of its low resistance to the irradiation.cross-immunity; syngeneic tumors; irradiated ascites tumor cells

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contrasting

confidence: 99%

Cross-immunity between syngeneic tumors in mice immunized with gamma-irradiated ascites tumors.

Kudo¹,

Waga²,

Sato³

et al. 1980

Tohoku J. Exp. Med.

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“…It may be understood in the same way that cross-immunity was difficult to be demonstrated in various reports in which only irradiated tumor cells or only one inoculation of living tumor cells were employed as immunization. Usubuchi et al (1972a) pointed out in the experiments using allogeneic tumors that antigenicity of tumors consists of common and individual unique antigen(s). The latter was considered to derive from the difference of antigenicity of the primary tumor host.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, cross-immunity was observed among allogeneic tumors in rats as well as among chemically induced syngeneic tumors in mice. The autotransplantation of MCA-induced sarcomas in rats was effectively inhibited by intense immunization with allogeneic tumors (Usubuchi et al 1972a(Usubuchi et al , b, 1973.…”

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confidence: 99%

Further studies on cross-immunity among syngeneic tumors of mice.

Usubuchi

Nishimura

Kudo

et al. 1975

Tohoku J. Exp. Med.

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“…This suggested that cross-immunity was induced by the common antigens between allogeneic tumors. The cross-immunity was observed not only between tumors of rats but also between tumors of C3H/He mice (Usubuchi et al 1966). On the basis of cross-immunity among tumors of rats and among those of mice, the inhibition of auto-transplantation of tumors was demonstrated in the primary autochthonous host immunized with allogeneic and syngeneic tumors (Usubuchi et al 1967(Usubuchi et al , 1969.…”

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confidence: 99%