Cross-immune tolerance: conception and its potential significance on transplantation tolerance

Zhao, Yong; Li, Xian Chang

doi:10.1038/cmi.2009.101

Cited by 5 publications

(2 citation statements)

References 62 publications

(74 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This phenomenon, which has been referred to as "bystander" regulation, has been demonstrated in vivo in the context of transplantation, where alloantigen-induced regulatory CD4 + T cells are able to extend the survival of third-party skin allografts when reactivated by the original antigen (14). Of note, the existence of bystander regulation has raised concerns about the potential to compromise immunity to pathogens in transplant recipients, where tolerance is induced (15). It has been the prevailing notion that the induction of tertiary lymphoid organs in allografts results in locally generated deleterious immune responses (16,17).…”

Section: Tolerance Induction After Lung Transplantation Is Associatedmentioning

confidence: 99%

Bronchus-associated lymphoid tissue–resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection

Li¹,

Gauthier²,

Higashikubo³

et al. 2018

Journal of Clinical Investigation

View full text Add to dashboard Cite

Section: Tolerance Induction After Lung Transplantation Is Associatedmentioning

confidence: 99%

Bronchus-associated lymphoid tissue–resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection

Li¹,

Gauthier²,

Higashikubo³

et al. 2018

Journal of Clinical Investigation

View full text Add to dashboard Cite

“…Although hematopoietic stem cell transplantation (HSCT) became a curative therapy for a wide range of hematological malignancies, donor T cells failing to reach the tolerant state in host microenvironment leads to severe graft versus host disease (GVHD) and threatens the survival of patients after HSCT. Several strategies have been developed to induce tolerance and minimizing GVHD occurrence post-HSCT, such as blockade of costimulatory signals, transforming growth factor beta and regulatory T cells (Treg) 1,2,3 .…”

Section: Introductionmentioning

confidence: 99%

Spatial Multiomics Analysis Identifies SOCS1 as a Key Immune Checkpoint in T cell Tolerance Induction of HSCT

Li¹,

Guo²,

Wang³

et al. 2021

Preprint

View full text Add to dashboard Cite

Achieving T cell tolerance ensures superior clinical outcomes in hematopoietic stem cell transplantation (HSCT). However, the in vivo T cell tolerance profiles in physiological state need to be further delineated. Here, we characterized the gene expression profile in tolerant T cells which was induced in healthy donors by granulocyte colony-stimulating factor, a stem cell mobilizer extensively used in HSCT. We identified suppressor of cytokine signaling 1 (SOCS1) as an essential immune checkpoint for T cell tolerance in the mouse models and primary T cells in the HSCT context. Further spatial multiomics analysis characterized the distinct three-dimensional genome architecture and the gene regulatory network in tolerant T cells. We found STAT3 competes with CTCF and mediates the formation of a new chromatin loop between the SOCS1 promoter and upstream super enhancers during the induction of T cell tolerance. This study identifies SOCS1 as a key immune checkpoint and potential immune target for improving outcome of patients with HSCT.

show abstract

Dendritic cells transduced with lentiviral vector targeting RelB gene using RNA interference induce hyporesponsiveness in memory CD4+ T cells and naïve CD4+ T cells

Luo

et al. 2012

Cellular Immunology

View full text Add to dashboard Cite

Cross-immune tolerance: conception and its potential significance on transplantation tolerance

Cited by 5 publications

References 62 publications

Bronchus-associated lymphoid tissue–resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection

Bronchus-associated lymphoid tissue–resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection

Spatial Multiomics Analysis Identifies SOCS1 as a Key Immune Checkpoint in T cell Tolerance Induction of HSCT

Dendritic cells transduced with lentiviral vector targeting RelB gene using RNA interference induce hyporesponsiveness in memory CD4+ T cells and naïve CD4+ T cells

Contact Info

Product

Resources

About