Cross-elicitation responses to 2-methoxymethyl-<i>p</i>-phenylenediamine under hair dye use conditions in<i>p</i>-phenylenediamine-allergic individuals

Blömeke, Brunhilde; Pot, Linda; Coenraads, Pieter‐Jan; Hennen, Jennifer; Kock, Monika; Goebel, Carsten

doi:10.1111/bjd.13412

Cited by 18 publications

(32 citation statements)

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“…In summary, we found that pretesting with the ME‐PPD‐containing hair colour product of choice was predictive for 77% of PPD/PTD‐allergic individuals (33 of 43), and 67% (29 of 43) tolerated continuous hair colouring during the observation period of approximately 1 year. This indicates that due to its structural difference, the recognition of ME‐PPD by the immune system of a considerable number of allergic individuals is reduced, or possibly completely lacking in some cases . This is in line with the primary prevention benefit of ME‐PPD in terms of significantly reduced skin sensitization potency for all hair colour consumers …”

Section: Discussionsupporting

confidence: 65%

“…). The limited cross‐elicitation rate to the full hair colour treatments of 33% (14 of 43) is comparable with the cross‐elicitation rate of 30% to a 30‐min forearm exposure simulating hair dyeing with the maximum ME‐PPD concentration of 2% …”

Section: Discussionmentioning

confidence: 62%

“…These shades were grouped into three tonal shade levels (dark to medium‐dark, medium‐light, light), with appropriate concentration ranges of ME‐PPD (Table ). The formulation base was equivalent to that of conventional hair dye products, comparable with Blömeke et al . and Goebel et al ., and additionally containing fragrance.…”

Section: Methodsmentioning

confidence: 75%

“…However, despite warnings not to use ME‐PPD hair colorants in case of hair dye allergy, individuals with existing allergy to PPD and/or PTD are still likely considering the use of ME‐PPD‐containing hair dye products as an alternative. Consequently, in our present study we extended our previously reported analysis of the cross‐elicitation response to ME‐PPD in PPD‐allergic individuals . We asked whether PPD/PTD‐allergic individuals tolerate full hair colour treatments with their preferred ME‐PPD‐containing shade upon negative pretesting on their forearm.…”

Section: Discussionmentioning

confidence: 81%

“…application of the hair colour tint mixed with hydrogen peroxide for approximately 30–45 min followed by rinsing). Cross‐elicitation to the ME‐PPD‐containing hair dye test product occurred in nine of 30 individuals (30%), while 70% did not react …”

mentioning

confidence: 99%

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Continuous usage of a hair dye product containing 2‐methoxymethyl‐para‐phenylenediamine by hair‐dye‐allergic individuals

et al. 2016

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Funding sourcesNone. Conflicts of interest SummaryBackground Despite a positive patch test reaction to para-phenylenediamine (PPD) and/or toluene-2,5-diamine (PTD), many people attempt to continue dyeing their hair with products containing PPD or its derivatives. Objectives Investigation of elicitation reactions among PPD/PTD-allergic individuals to hair dye products containing the less sensitizing PPD derivative 2-methoxymethyl (ME)-PPD. Methods Elicitation reactions were studied in 43 PPD/PTD-allergic individuals by a 45-min pretest with an ME-PPD-containing hair dye on their forearm. Upon a negative result this was followed by exposure to subsequent hair colour treatment(s). Results Overall, 38 of 43 PPD/PTD-allergic individuals did not develop an elicitation reaction during the pretest with ME-PPD-containing hair dye products, and were eligible for subsequent hair colour treatments. Of these 38 PPD/PTD-allergic individuals, 29 tolerated subsequent hair dyeing with ME-PPD-containing hair dye products, while seven showed mild and two showed moderate/marked allergic reactions upon the first hair colour treatment. Conclusions Hair dye products with the less sensitizing ME-PPD were tolerated by 29 of 43 (67%) PPD/PTD-allergic individuals throughout continued hair dyeing with an average of nine treatments per year. Five individuals reacted upon pretesting, while only mild-to-moderate/marked skin reactions occurred upon hair dyeing in nine individuals who were not identified by the pretest. To our knowledge this is the first study among PPD/PTD-allergic individuals indicating that a negative 45-min pretest with a hair dye product helps to avoid severe allergic reactions.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 62%

Section: Methodsmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 81%

mentioning

confidence: 99%

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Continuous usage of a hair dye product containing 2‐methoxymethyl‐para‐phenylenediamine by hair‐dye‐allergic individuals

et al. 2016

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Occupational Hand Dermatitis

Karagounis

Cohen

2023

Curr Allergy Asthma Rep

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Purpose of Review Occupational hand dermatitis is a common work-related disorder of the skin. Prevention and management of this disease is critical to improving workers’ quality of life and for occupation-specific retention. Recent Findings This is a critical review of the current literature on occupational hand dermatitis. Occupational dermatitis continues to have a high prevalence among workers although the overall incidence may be slowly decreasing. Irritant contact dermatitis due to wet work exposure is the most common cause of occupational hand dermatitis. Healthcare workers, hairdressers, and metal workers are at particularly high risk for this disease. While some prevention programs have been ineffective in mitigating occupational hand dermatitis, other more resource-intensive initiatives may have benefit. Summary Continued research is needed on ways to manage wet work exposures and on scalable, effective prevention programs for occupational hand dermatitis. The spectrum of culprit contact allergens continues to evolve, and vigilance for potential occupation-specific allergens remains important.

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2-Methoxymethyl-para-phenylenediamine–containing hair dye as a less allergenic alternative for para-phenylenediamine–allergic individuals

Zirwas¹,

Dobkin

2019

Journal of the American Academy of Dermatology

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Cross-elicitation responses to 2-methoxymethyl-p-phenylenediamine under hair dye use conditions inp-phenylenediamine-allergic individuals

Cited by 18 publications

References 27 publications

Continuous usage of a hair dye product containing 2‐methoxymethyl‐para‐phenylenediamine by hair‐dye‐allergic individuals

Continuous usage of a hair dye product containing 2‐methoxymethyl‐para‐phenylenediamine by hair‐dye‐allergic individuals

Occupational Hand Dermatitis

2-Methoxymethyl-para-phenylenediamine–containing hair dye as a less allergenic alternative for para-phenylenediamine–allergic individuals

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