Cross electro-nape-acupuncture ameliorates cerebral hemorrhage-induced brain damage by inhibiting necroptosis

Cai, Guofeng; Sun, Zhaoqing; Zhuang, Zhe; Zhou, Haichun; Gao, Shan; Liu, Kai; Shang, Lili; Jia, Kunping; Wang, Xiuzhen; Zhao, Hui; Cai, Guoliang; Song, Wenli; Xu, Shengnan

doi:10.12998/wjcc.v8.i10.1848

Cited by 7 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EA at Fengchi (GB20), and Yifeng (TE17) reduces up-regulation of RIPK1, p-RIPK3, and p-MLKL, partially blocking the interaction between RIPK1 and RIPK3, thereby reducing levels of TNF-α, L-6, IL-8, and other inflammatory factors, to improve traumatic neuritis after intracerebral hemorrhage, and slow down the formation of perihematoma brain edema. 56 In the paclitaxel-induced neuropathic pain model, EA at ST36 and BL60 can alleviate the central inflammatory response by inhibiting the activation of spinal cord astrocytes and microglia and reducing the overexpression of TLR4 and the downstream signals MyD88 and transient receptor potential vanilloid-1 (TRPV-1) in the rat dorsal root ganglion (DRG). 57 EA at GV20, LI4, and LR3 also inhibits microglial activation and phosphorylation of IκBα and prevents the nuclear translocation of NF-κB p65 by upregulating the A20-binding inhibitor of NF-κB1 (ABIN1).…”

Section: Resultsmentioning

confidence: 99%

The Anti-Inflammatory Actions and Mechanisms of Acupuncture from Acupoint to Target Organs via Neuro-Immune Regulation

Li¹,

Guo²,

Gong³

et al. 2021

JIR

View full text Add to dashboard Cite

Inflammation plays a significant role in the occurrence and development of multiple diseases. This study comprehensively reviews and presents literature from the last five years, showing that acupuncture indeed exerts strong anti-inflammatory effects in multiple biological systems, namely, the immune, digestive, respiratory, nervous, locomotory, circulatory, endocrine, and genitourinary systems. It is well known that localized acupuncture-mediated anti-inflammatory effects involve the regulation of multiple populations and functions of immune cells, including macrophages, granulocytes, mast cells, and T cells. In acupuncture stimulation, macrophages transform from the M1 to the M2 phenotype and the negative TLR4 regulator PPARγ is activated to inhibit the intracellular TLR/MyD88 and NOD signaling pathways. The downstream IκBα/NF-κB and P38 MAPK pathways are subsequently inhibited by acupuncture, followed by suppressed production of inflammasome and proinflammatory mediators. Acupuncture also modulates the balance of helper T cell populations. Furthermore, it inhibits oxidative stress by enhancing SOD activity via the Nrf2/ HO-1 pathway and eliminates the generation of oxygen free radicals, thereby preventing inflammatory cell infiltration. The anti-inflammatory effects of acupuncture on different biological systems are also specific to individual organ microenvironments. As part of its anti-inflammatory action, acupuncture deforms connective tissue and upregulates the secretion of various molecules in acupoints, further activating the NF-κB, MAPK, and ERK pathways in mast cells, fibroblasts, keratinocytes, and monocytes/macrophages. The somatic afferents present in acupuncture-activated acupoints also convey sensory signals to the spinal cord, brainstem, and hypothalamic neurons. Upon information integration in the brain, acupuncture further stimulates multiple neuro-immune pathways, including the cholinergic anti-inflammatory, vagus-adrenal medulla-dopamine, and sympathetic pathways, as well as the hypothalamus-pituitary-adrenal axis, ultimately acting immune cells via the release of crucial neurotransmitters and hormones. This review provides a scientific and reliable basis and viewpoints for the clinical application of acupuncture in various inflammatory conditions.

show abstract

Section: Resultsmentioning

confidence: 99%

The Anti-Inflammatory Actions and Mechanisms of Acupuncture from Acupoint to Target Organs via Neuro-Immune Regulation

Li¹,

Guo²,

Gong³

et al. 2021

JIR

View full text Add to dashboard Cite

show abstract

“…As a combination of acupuncture and modern medical techniques, CENA highlights its superior therapeutic effects over traditional acupuncture. Previous studies have shown that CENA not only promotes cough reflex function and swallowing function remodelling in stroke patients but also controls lung infection, accelerates ventilator withdrawal, and promotes recovery from impaired consciousness [ 32 – 35 ]. Therefore, the same CENA method was used in this study to observe its therapeutic effect on patients with severe cerebral haemorrhage tracheotomy intubation with pseudobulbar palsy.…”

Section: Discussionmentioning

confidence: 99%

[Retracted] A Multicentre Randomized Controlled Clinical Study of Cross Electro‐Nape‐Acupuncture (CENA) for the Treatment of Pseudobulbar Palsy in Patients with Tracheotomy Intubation for Severe Cerebral Haemorrhage

Guo

Sun

et al. 2023

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. The objective is to evaluate the clinical efficacy of cross electro-nape-acupuncture (CENA) in the treatment of pseudobulbar palsy in patients with tracheotomy intubation for severe cerebral haemorrhage and to provide an innovative acupuncture method for the treatment of such patients. Methods. A total of 126 patients from six trial centres who met the inclusion criteria were randomly divided into three groups according to the random number table method in the ratio of 1 : 1 : 1, with 42 patients in each group, and the three groups were divided into CENA group, electro-acupuncture group, and acupuncture group. Each group’s acupuncture treatment lasted for 30 minutes, and the needles were removed at the end of the treatment. Acupuncture was performed once a week on Sunday only and twice a day from Monday to Saturday, a total of 4 weeks of treatment. The SWT, FDA, ChSWAL-QOL, and TCRGS scores of the three groups of patients before and after treatment were compared to evaluate the effect of CENA on remodelling the function of swallowing reflex and cough reflex and promoting the recovery of dysarthria and swallowing quality of life in pseudobulbar palsy in patients with tracheotomy intubation for severe cerebral haemorrhage. Results. After treatment, the WST and TCRGS grade scores decreased and the FDA and ChSWAL-QOL scores increased significantly in all three groups compared with the pretreatment scores and were statistically significant. There was a significant difference between the three groups for these four indicators after treatment; the comparison between groups showed significant differences in the CENA group compared to the electro-acupuncture and acupuncture groups. The efficiency of the CENA group was significantly better than that of the electro-acupuncture and acupuncture groups. Conclusion. Compared with the acupuncture and electro-acupuncture groups, the CENA could better promote the remodelling of swallowing function and cough reflex function, promote the recovery of dysarthria, and better improve the quality of life of patients with pseudobulbar palsy from tracheotomy intubation in severe cerebral haemorrhage.

show abstract

Unwinding the modalities of necrosome activation and necroptosis machinery in neurological diseases

Gupta

Smita

Tripathi

et al. 2023

Ageing Research Reviews

View full text Add to dashboard Cite

Cross electro-nape-acupuncture ameliorates cerebral hemorrhage-induced brain damage by inhibiting necroptosis

Cited by 7 publications

References 42 publications

The Anti-Inflammatory Actions and Mechanisms of Acupuncture from Acupoint to Target Organs via Neuro-Immune Regulation

The Anti-Inflammatory Actions and Mechanisms of Acupuncture from Acupoint to Target Organs via Neuro-Immune Regulation

[Retracted] A Multicentre Randomized Controlled Clinical Study of Cross Electro‐Nape‐Acupuncture (CENA) for the Treatment of Pseudobulbar Palsy in Patients with Tracheotomy Intubation for Severe Cerebral Haemorrhage

Unwinding the modalities of necrosome activation and necroptosis machinery in neurological diseases

Contact Info

Product

Resources

About