Connectedness is essential to human growth and learning. This chapter presents an analysis on connections-based learning from four distinct frameworks: intrapersonal, interpersonal, interdisciplinary, and media-based. It includes a model that shows different levels of interactions in adult learning. Adults can learn anything and everything about any subject through the connections they establish with the world in a lifelong process based on the way we connect with ourselves, with others with different domains, and through different media. Learning is attained as in the weaving process of a seamless web that changes the way people see themselves and the world. Everything becomes interconnected, resembling a mesh.