Crospovidone

Barabas, Eugene S.; Adeyeye, Christianah Moji

doi:10.1016/s0099-5428(08)60692-9

Cited by 14 publications

(11 citation statements)

References 67 publications

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“…3f) manufactured by the proliferous polymerization of vinylpyrrolidone. 49,50 This polymer is also known as a "popcorn" polymer as it possesses a "popped" structure. There are 2 accepted methods to manufacture crospovidone.…”

Section: Crospovidonementioning

confidence: 99%

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Review of Disintegrants and the Disintegration Phenomena

Desai

Liew

Heng

2016

Journal of Pharmaceutical Sciences

246

140

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Section: Crospovidonementioning

confidence: 99%

“…In one method, the crosslinking agent is formed in situ whereas it is added in the other method. 49 The coarser crospovidone grades disintegrate tablets faster. 9 The amounts of crospovidone used in tablet formulations varied in literature reports.…”

Section: Crospovidonementioning

confidence: 99%

Review of Disintegrants and the Disintegration Phenomena

Desai

Liew

Heng

2016

Journal of Pharmaceutical Sciences

246

140

View full text Add to dashboard Cite

“…Very high conversions can be achieved and the resulting product, a granular "popcorn" mass, can be freed of residual monomer/soluble polymer by careful washing. Drying results in a free-flowing white powder (51).…”

Section: Proliferous Polymerizationmentioning

confidence: 99%

N‐Vinylamide Polymers

2000

Kirk-Othmer Encyclopedia of Chemical Technology

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N ‐Vinyl lactams and their corresponding polymers and copolymers have received considerable attention in the academic literature and significant commercial success. However, until recently this interest centered on N ‐vinyl pyrrolidinone and its polymers and copolymers. N ‐Vinyl caprolactam is now emerging commercially because copolymerization with N ‐vinyl pyrrolidinone results in copolymers with high levels of lactam functionality but with controlled hydrophobicity desired in many hair‐fixative products designed to resist drop in high humidity environments. Polyvinylpyrrolidinone (PVP) is a unique water‐soluble polymer that forms lustrous, continuous films on dry‐down that are very adhesive because of hydrogen‐bonding to substrates such as skin and hair. This adhesive characteristic also results in a wide variety of useful applications such as pharmaceutical tablet binding, hot‐melt, and paper adhesive applications. PVP is relatively nontoxic and contributes mildness to formulations. PVP will also complex with a variety of small and large molecules because the pyrrolidinone carbonyl group can accept a proton in the presence of large anions, becoming pseudocationic. In addition, because of lactam polarity where significant charge can appear on the nitrogen and oxygen atoms, it can interact with electron‐rich aromatics. Ligands such as anionic dyes and surfactants or triiodide or phenolic or polynuclear aromatics or polyacids, etc, will interact and complex with PVP. PVPHI 3 or povidone‐iodine is probably the most successful of these complexes, retaining a reservoir of iodine even in dilute solution, affording fresh germicidal iodine as free iodine is consumed. Cross‐linked PVP or crospovidone can be employed to remove bitter tannins (phenolics) from beer and wine. Dry crospovidone can be compressed because of interhydrogen‐bonding, only to rapidly swell when exposed to moisture. For this reason it has achieved success as a tablet disintegrant.

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“…As the particle size increases, the intra-particular porosity increases, leading to a larger water uptake and faster disintegration. Several grades of crospovidone are available, differing in particle size distribution, bulk density and hydration capacity [110].…”

mentioning

confidence: 99%

“…This polymer can also be used for solubility enhancement of poorly soluble drugs in the process of coevaporation. This process enables the drug adsorption onto crospovidone in the presence of a suitable solvent, and once the solvent is evaporated, a solid mixture with a faster drug dissolution rate is provided [110]. Sometimes, crospovidone is included as part of highly hydrophilic matrices, for example, in mixtures with poly(acrylic acid), and xanthan gum.…”

mentioning

confidence: 99%

In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations

et al. 2020

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The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In some cases the drug is barely soluble; in others, the rapid transit of the formulation through the gastrointestinal tract (GIT) makes it difficult to achieve therapeutic levels in the organism; moreover, some drugs must act locally due to a gastric pathology, but the time they remain in the stomach is short. The use of formulations capable of improving all these parameters, as well as increasing the resident time in the stomach, has been the target of numerous research works, with low-density systems being the most promising and widely explored, however, there is further scope to improve these systems. There are a vast variety of polymeric materials used in low-density gastroretentive systems and a number of methods to improve the bioavailability of the drugs. This works aims to expedite the development of breakthrough approaches by providing an in-depth understanding of the polymeric materials currently used, both natural and synthetic, their properties, advantages, and drawbacks.

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Crospovidone

Cited by 14 publications

References 67 publications

Review of Disintegrants and the Disintegration Phenomena

Review of Disintegrants and the Disintegration Phenomena

N‐Vinylamide Polymers

In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations

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