Crop Plants Develop Extracellular Signaling Products Against Salt Stress

Tiwari, Santwana; Verma, Nidhi; Singh, Shikha; Gupta, Shivam; Singh, Madhulika; Singh, Pratibha; Pandey, Jitendra; Prasad, Sheo Mohan

doi:10.1002/9781119700517.ch12

Cited by 2 publications

(3 citation statements)

References 118 publications

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“…Passive targeting to tackle cancer cells is based on the intrinsic physicochemical properties of the nanocarriers (size and surface chemistry) and the specific features of the tumor microenvironment, including the enhanced permeability and retention effect. This phenomenon leads to the accumulation of nanocarriers within tumor tissues, thanks to the upregulated angiogenesis that results in an impaired vasculature [52]. Passive targeting strategies have been investigated for the delivery of a wide range of drugs, including those with a primary mechanism of action centered in the GA, such as BFA, monensin, and salinomycin and prodigiosin.…”

Section: Passive Targetingmentioning

confidence: 99%

“…Antibodies and aptamers are widely recognized as highly specific targeting moieties. Other active strategies often explored in the field of anticancer therapy comprise ligand-receptor interactions and peptides [52]. Various active-targeting approaches have been used to specifically deliver GA-acting drugs to cancer cells or to the specific organelle (Figure 5).…”

Section: Active Targetingmentioning

confidence: 99%

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The Golgi Apparatus as an Anticancer Therapeutic Target

Martins,

Vieira,

Pereira-Leite

et al. 2023

Biology

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Although the discovery of the Golgi apparatus (GA) was made over 125 years ago, only a very limited number of therapeutic approaches have been developed to target this complex organelle. The GA serves as a modification and transport center for proteins and lipids and also has more recently emerged as an important store for some ions. The dysregulation of GA functions is implicated in many cellular processes associated with cancer and some GA proteins are indeed described as cancer biomarkers. This dysregulation can affect protein modification, localization, and secretion, but also cellular metabolism, redox status, extracellular pH, and the extracellular matrix structure. Consequently, it can directly or indirectly affect cancer progression. For these reasons, the GA is an appealing anticancer pharmacological target. Despite this, no anticancer drug specifically targeting the GA has reached the clinic and few have entered the clinical trial stage. Advances in nanodelivery approaches may help change this scenario by specifically targeting tumor cells and/or the GA through passive, active, or physical strategies. This article aims to examine the currently available anticancer GA-targeted drugs and the nanodelivery strategies explored for their administration. The potential benefits and challenges of modulating and specifically targeting the GA function in the context of cancer therapy are discussed.

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Section: Passive Targetingmentioning

confidence: 99%

Section: Active Targetingmentioning

confidence: 99%

The Golgi Apparatus as an Anticancer Therapeutic Target

Martins,

Vieira,

Pereira-Leite

et al. 2023

Biology

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“…Due of the wide range of applications for nanotechnology, including drug administration, cell labelling, cancer therapy, anti-microbial medicines, and diagnostics, progress in this field has remained consistent on a global scale [5]. Nanoparticles have distinctive features that depend on their morphology, shape, and size, which permit them to interact with plants and animals, as well as microorganisms [6].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Quercetin-Loaded Silver Nanoparticles and Assessing Their Anti-Bacterial Potential

Sharma,

Basist,

Alhalmi

et al. 2023

Micromachines

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The study delves into the multifaceted potential of quercetin (Qu), a phytoconstituent found in various fruits, vegetables, and medicinal plants, in combination with silver nanoparticles (AgNPs). The research explores the synthesis and characterization of AgNPs loaded with Qu and investigates their pharmaceutical applications, particularly focusing on antibacterial properties. The study meticulously evaluates Qu’s identity, and physicochemical properties, reaffirming its suitability for pharmaceutical use. The development of Qu-loaded AgNPs demonstrates their high drug entrapment efficiency, ideal particle characteristics, and controlled drug release kinetics, suggesting enhanced therapeutic efficacy and reduced side effects. Furthermore, the research examines the antibacterial activity of Qu in different solvents, revealing distinct outcomes. Qu, both in methanol and water formulations, exhibits antibacterial activity against Escherichia coli, with the methanol formulation displaying a slightly stronger efficacy. In conclusion, this study successfully synthesizes AgNPs loaded with Qu and highlights their potential as a potent antibacterial formulation. The findings underscore the influence of solvent choice on Qu’s antibacterial properties and pave the way for further research and development in drug delivery systems and antimicrobial agents. This innovative approach holds promise for addressing microbial resistance and advancing pharmaceutical formulations for improved therapeutic outcomes.

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Crop Plants Develop Extracellular Signaling Products Against Salt Stress

Cited by 2 publications

References 118 publications

The Golgi Apparatus as an Anticancer Therapeutic Target

The Golgi Apparatus as an Anticancer Therapeutic Target

Synthesis of Quercetin-Loaded Silver Nanoparticles and Assessing Their Anti-Bacterial Potential

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