Cronkhite-Canada syndrome

Vashistha, Nitin; Chakravarty, Suneel; Singhal, Dinesh

doi:10.1016/j.gie.2017.05.028

Cited by 5 publications

(3 citation statements)

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“…The previous study with large sample size has reported that males and people aged 50–60 were the high-risk group [5‒7]. There were also a few sporadic cases reported among young people [9, 10]. Our findings from Chinese CCS patients were very similar with those results from other areas.…”

Section: Discussionsupporting

confidence: 88%

Clinical and Endoscopic Characteristics of Chinese Cronkhite-Canada Syndrome Patients: A Retrospective Study of 103 Cases

Huang

Wang

et al. 2021

Dig Dis

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Introduction: Cronkhite-Canada syndrome (CCS) is a rare non-inherited disease characterized by extensive gastrointestinal (GI) polyposis and ectodermal dysplasia. So far, most of CCS related literatures are published as single case report or reviewed with limited case numbers. Our study was to update the clinical and endoscopic characteristics of Chinese CCS patients. Methods: This retrospective study was conducted in 103 Chinese CCS patients (102 cases from literatures and 1 case from our department). Their clinical and endoscopic data were collected, and statistical analyses were performed. Results: 1) In Chinese population, people aged 50-70 years (62.62%) had a high incidence of CCS, and the ratio of male-to-female was 2.68:1. 2) The diverse range of GI manifestations were observed in all the patients, and almost all the patients had at least one symptom of ectodermal dysplasias. 3) All CCS patients presented multiple polyps in the GI tract except esophagus, and the size and appearance of polyps were diverse. Congestion, edema and erosion were very common on the surface of polyps (96.83%) and the surrounding mucosa (85.71%) . 4) The common pathological features of polyps were hyperplastic polyps (49.25%) and tubular adenomatous polyps (44.78%). There is 5.97% cancer reported. Conclusions: middle-aged and elderly people are the high-risk group; various GI symptoms are observed in Chinese patients; the typical endoscopic finding is multiple small sessile polyps; these GI polyps has a chance of malignant potential. Long-term endoscopic surveillance and follow-up are recommended for the Chinese CCS patients. Key words: Cronkhite-Canada syndrome, Clinical characteristics, Endoscopy

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Section: Discussionsupporting

confidence: 88%

Clinical and Endoscopic Characteristics of Chinese Cronkhite-Canada Syndrome Patients: A Retrospective Study of 103 Cases

Huang

Wang

et al. 2021

Dig Dis

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“…Available treatments, either alone or in combination, include steroids, nutritional therapy (fluid, electrolyte, protein, and vitamin supplementation and, if necessary, elemental diet or parenteral nutrition), 5-aminosalicylic acid, antagonists of histamine H2 receptors, anti-tumor necrosis factor alpha agents, immunomodulators and Helicobacter pylori eradication [1][2][3][4][5][6][7][8][9][10].…”

Section: Discussionmentioning

confidence: 99%

Protein-Losing Enteropathy, Anasarca and Dermatological Manifestations on People of Advanced Age: Don't Overlook the Diagnostic Hypothesis of a Cronkhite Canada Syndrome

2023

WJCMI

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Cronkhite-Canada syndrome is a rare and non-genetic syndrome of unknown etiology, characterized by diffuse gastrointestinal polyposis, the dermatological triad (nail distrophy, hyperpigmentation, alopecia), diarrhea, weight loss and abdominal pain. Herein, we describe a late-onset case that experienced relief after prednisone treatment. It is very important keep in mind the clinical hypothesis of this syndrome, because an early diagnosis can help reduce morbidity and mortality associated with this pathology, which is often life threatening

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“…Cronkhite–Canada syndrome is a disease involving multiple gastrointestinal polyps and other manifestations. 1 , 2 Most patients exhibit hypoalbuminemia (<30 g/L) with reduced total serum protein (<60 g/L). 3 The disease was first reported in 1955, 4 and was named Cronkhite–Canada syndrome by Jarnum and Jensen in 1966; 5 however, the etiology and cause have remained unclear thus far.…”

Section: Introductionmentioning

confidence: 99%