Crohn’s-like reaction in diverticular disease

Gledhill, A. W.; Dixon, M. F.

doi:10.1136/gut.42.3.392

Cited by 129 publications

(54 citation statements)

References 13 publications

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“…This is consistent with an M. avium subsp. paratuberculosis superinfection in a preexisting abnormality and is in line with the previous description of typical changes associated with CD affecting a segment of colon with diverticulitis (13). A fifth patient diagnosed with lymphocytic colitis had extensive intraepithelial lymphocytosis throughout the colon.…”

Section: Discussionsupporting

confidence: 68%

Detection and Verification of Mycobacterium avium subsp. paratuberculosis in Fresh Ileocolonic Mucosal Biopsy Specimens from Individuals with and without Crohn's Disease

Bull¹,

McMinn²,

et al. 2003

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Mycobacterium avium subsp. paratuberculosis is a robust and phenotypically versatile pathogen which causes chronic inflammation of the intestine in many species, including primates. M. avium subsp. paratuberculosis infection is widespread in domestic livestock and is present in retail pasteurized cows' milk in the United Kingdom and, potentially, elsewhere. Water supplies are also at risk. The involvement of M. avium subsp. paratuberculosis in Crohn's disease (CD) in humans has been uncertain because of the substantial difficulties in detecting this pathogen. In its Ziehl-Neelsen staining-negative form, M. avium subsp. paratuberculosis is highly resistant to chemical and enzymatic lysis. The present study describes the development of optimized sample processing and DNA extraction procedures with fresh human intestinal mucosal biopsy specimens which ensure access to M. avium subsp. paratuberculosis DNA and maximize detection of these low-abundance pathogens. Also described are two nested PCR methodologies targeted at IS900, designated IS900

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Section: Discussionsupporting

confidence: 68%

Detection and Verification of Mycobacterium avium subsp. paratuberculosis in Fresh Ileocolonic Mucosal Biopsy Specimens from Individuals with and without Crohn's Disease

Bull¹,

McMinn²,

et al. 2003

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“…Both CD and JID are seen with sufficient frequency that unless one disease protects from the other, one would occasionally expect to see coincident disease (21,22).…”

Section: Discussionmentioning

confidence: 99%

Rare Coexistance of Ileal Diverticulosis, Crohn’s Disease and Small Bowel Adenocarcinoma: Report of a Case

Spartalis

Garmpis

Spartalis

et al. 2018

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“…However, some other studies indicated that some patients with SCADD may progress to clinically subsequent ‘classic’ Crohn’s disease. Gledhill and Dixon [22 ]and Burroughs et al [26 ]both reported 17 cases of diverticular colitis with Crohn’s-like features. Those have been followed and only 2 cases subsequently developed Crohn’s disease.…”

Section: Diverticular Colitismentioning

confidence: 99%

“…Gledhill and Dixon [22] reported 11 cases of Crohn’s disease-type diverticulitis with typical ‘classic’ histological features of Crohn’s disease-like transmural inflammation, granulomas and ulceration. In 9 patients, the features were confined to the resected specimens only and none of these patients progressed to full-blown Crohn’s disease.…”

Section: Diverticular Colitismentioning

confidence: 99%

Pathology and Pathogenesis of Diverticular Disease and Patterns of Colonic Mucosal Changes Overlying the Diverticula

Haboubi¹,

Al–Qudah

2012

Dig Dis

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The aim of this article is to review the pathology of diverticular disease and draw attention to the histological changes that affect the wall and the mucosal lining of the sigmoid colon in this common condition. We were the first group to propose a histological classification for sigmoid colitis-associated diverticular disease, and in this paper we are adding another feature to our original observation.

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Crohn’s-like reaction in diverticular disease

Abstract: (Gut 1998;42:392-395)

Cited by 129 publications

References 13 publications

Detection and Verification of Mycobacterium avium subsp. paratuberculosis in Fresh Ileocolonic Mucosal Biopsy Specimens from Individuals with and without Crohn's Disease

Detection and Verification of Mycobacterium avium subsp. paratuberculosis in Fresh Ileocolonic Mucosal Biopsy Specimens from Individuals with and without Crohn's Disease

Rare Coexistance of Ileal Diverticulosis, Crohn’s Disease and Small Bowel Adenocarcinoma: Report of a Case

Pathology and Pathogenesis of Diverticular Disease and Patterns of Colonic Mucosal Changes Overlying the Diverticula

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