Crohn's disease should be considered in children with inflammatory oral lesions

Skrzat, Anna; Olczak‐Kowalczyk, Dorota; Turska‐Szybka, Anna

doi:10.1111/apa.13686

Cited by 16 publications

(26 citation statements)

References 37 publications

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“…CD is a multifactorial, relapsing inflammatory disease typically affecting the gastrointestinal tract 1. It is a chronic disease with a wide spectrum of clinical manifestations including the involvement of the oral cavity 5. Though the incidence of CD in children of the western countries is stabilising, incidence in the newly industrialised countries increased, ranging from 3 to 30 per 100 000, affecting predominantly the ileum and the colon 6.…”

Section: Discussionmentioning

confidence: 99%

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Crohn’s disease initiated with extraintestinal features

Chang

Li²,

Achtari

et al. 2019

BMJ Case Rep

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Crohn’s disease (CD) is a multifactorial, chronic immune-mediated disorder. The oral cavity is involved in 0.5% to 20% of the patients with CD. Oral manifestations of CD are sometimes nonspecific and can be overlooked by the clinicians. These manifestations may precede intestinal symptoms and can serve as indicators for early diagnosis. To increase awareness and to contribute to the standard intervention, here we report a paediatric case with persistent idiopathic swelling of the lower lip and perianal fistula. Microscopic examinations revealed multiple non-necrotising granulomas with chronic inflammation, oedema and lymphangiectasia. The patient was treated with metronidazole 500 mg and ciprofloxacin 500 mg twice a day for one month. The perioral lesions were managed with topical 0.03% tacrolimus and oral prednisone 10 mgtwice a day for one month, followed by a tapered regimen of 10 mg/day for another month. The patient’s symptoms improved without full remission at the 6-month follow-up.

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Section: Discussionmentioning

confidence: 99%

“…Due to the nonspecificity of these symptoms, the oral manifestations of CD may not always be carefully evaluated. Especially in children, oral manifestations of CD may precede or coincide with intestinal symptoms and can serve as an important indicator for early diagnosis in this regard 5…”

Section: Introductionmentioning

confidence: 99%

Crohn’s disease initiated with extraintestinal features

Chang

Li²,

Achtari

et al. 2019

BMJ Case Rep

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“…Oral manifestations of Crohn's disease are common. A systematic review of 28 articles revealed that oral lesions occur in 10%‐80% of children with Crohn's disease. Lazzerini and colleagues investigated pediatric orofacial granulomatosis and found that 70 of 173 children were also diagnosed with Crohn's disease.…”

Section: Discussionmentioning

confidence: 99%

Orofacial granulomatosis and erythema multiforme in an adolescent with Crohn's disease

Georgesen

Huang

Avarbock

et al. 2018

Pediatric Dermatology

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The cutaneous manifestations of Crohn's disease are myriad. A 15-year-old girl presented with recurrent lip swelling and eventual development of diarrhea and targetoid macules on the palms, feet, and back. She was finally diagnosed with Crohn's disease in the setting of a clinical presentation and histopathology consistent with orofacial granulomatosis and erythema multiforme. We review the literature and summarize reported occurrences of these cutaneous diseases in children with Crohn's disease.

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“…Seit damals ist eine Reihe von Fallberichten über Patienten erschienen, bei denen die Crohn-Erkrankung auf Grund schwerer oraler Läsionen diagnostiziert werden konnte [11][12][13][14][15][16][17][18]. Eine aktuelle Literaturübersicht zu Morbus Crohn bei Kindern ergab eine Häufigkeit von oralen Läsionen zwischen 10 und 80 % [19].…”

Section: Einführungunclassified

Früherkennung von Morbus Crohn anhand von oralen Manifestationen bei einer Patientin mit Marfan-Syndrom

Topbas

Bremen

Gattenlöhner

et al. 2018

Inf Orthod Kieferorthop

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Zusammenfassung Ziel Dieser Fallbericht zeigt eine Patientin mit der Anamnese des Marfan-Syndroms (MFS) und einer atypischen gingivalen Hyperplasie, die zu einer frühen Diagnose von Morbus Crohn führte. Material und Methoden Die Patientin zeigte typische kraniofaziale Manifestationen des Marfan-Syndroms. Zusätzlich stellte sich eine zunächst einseitige, dann symmetrische atypische Gingivahyperplasie im Frontzahnbereich dar. Die antiinfektiöse Parodontaltherapie verbesserte den überlagerten entzündlichen Teil des hyperplastischen Parodonts, aber die Hyperplasie blieb zu einem großen Teil bestehen. Ergebnisse Die vermutete frühe Manifestation des Morbus Crohn im Oralbereich wurde histologisch durch eine Biopsie bestätigt. Morbus Crohn wurde anschließend durch eine internistische Endoskopie verifiziert. Fazit Das Durchschnittsalter der Patienten, die sich einer kieferorthopädischen Behandlung unterziehen, entspricht dem Alter, in dem sich systemische Erkrankungen oft zum ersten Mal manifestieren. Orale Symptome können die ersten Anzeichen einer systemischen Erkrankung sein, wie in diesem Fall Morbus Crohn, und bieten somit die Möglichkeit zur Früherkennung durch Kieferorthopäden und Allgemeinzahnärzte.

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Crohn's disease should be considered in children with inflammatory oral lesions

Cited by 16 publications

References 37 publications

Crohn’s disease initiated with extraintestinal features

Crohn’s disease initiated with extraintestinal features

Orofacial granulomatosis and erythema multiforme in an adolescent with Crohn's disease

Früherkennung von Morbus Crohn anhand von oralen Manifestationen bei einer Patientin mit Marfan-Syndrom

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