Crohn's disease of the vulva: A prospective study

Bhoyrul, Bevin; Lyon, C. C.

doi:10.1111/jgh.14291

Cited by 25 publications

(27 citation statements)

References 16 publications

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“…Children in particular frequently experience no gastrointestinal complaints . Cutaneous findings are usually characterized by erythema and edema with fissures and ulcerations in the genital and – less frequently – extragenital region . Linear inflammatory ulcerations or cutaneous granulomas in the skin folds or on the lower extremities may be an indication of cutaneous involvement.…”

Section: Granulomatous Dermatoses In Systemic Diseasementioning

confidence: 99%

Non‐infectious granulomatous dermatoses

Schmitt¹,

Völz

2019

J Deutsche Derma Gesell

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Summary Granulomatous dermatoses comprise a wide range of etiologically and clinically distinct skin diseases that share a common histology characterized by the accumulation of histiocytes include macrophages. While the pathogenesis of these disorders is not fully understood, the underlying mechanism is thought to involve a reaction pattern caused by an immunogenic stimulus. Antigen‐presenting cells and the effect of various cytokines play a key role. Our understanding of granulomatous reaction patterns has been advanced by insights drawn from observations of such reactions in patients on immunomodulatory therapy and in individuals with genetic immunodeficiency. Traditionally, a distinction is made between infectious and non‐infectious granulomatous dermatoses. The present CME article addresses granulomatous skin diseases for which there is no evidence of a causative infectious agent. Common representatives include granuloma annulare, necrobiosis lipoidica and cutaneous sarcoidosis. Granulomatous dermatoses may be part of the clinical spectrum of various systemic disorders or may be associated therewith. Some neoplastic disorders may mimic granulomatous dermatoses histologically. Given the pathogenetic diversity involved, the clinical presentation, too, is quite varied. Overall, however, each disorder is characterized by typical clinical features. The diagnosis always requires thorough clinicopathologic correlation. Treatment is preferably based on the underlying pathogenesis and frequently involves anti‐inflammatory agents. In most cases, however, there is insufficient study data. The dermal nature of these disorders frequently poses a therapeutic challenge, especially with respect to topical treatment.

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Section: Granulomatous Dermatoses In Systemic Diseasementioning

confidence: 99%

Non‐infectious granulomatous dermatoses

Schmitt¹,

Völz

2019

J Deutsche Derma Gesell

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“…However, treatment algorithms have been proposed by multiple authors. 2–5 Behavioral interventions involve compression underwear or shorts to aid with lymphatic drainage. First-line medical therapies include potent topical corticosteroids or topical calcineurin inhibitors.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Crohn’s disease of the vulva after a total colectomy and without gastrointestinal manifestations: A case report

Bohdanowicz

Ghazarian

Rosen

2019

SAGE Open Medical Case Reports

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“…47 Ulceration can be seen in approximately 35% of patients. 48 The average age at which CD is diagnosed is 34 years, and vulvar CD may precede the diagnosis by many years. 46 If “knife-cut” ulcers are present, they are commonly CD related.…”

Section: Noninfectious Causesmentioning

confidence: 99%

Genital Ulcer Disease: A Review of Pathogenesis and Clinical Features

et al. 2019

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Genital ulcer disease can be caused by a wide variety of sources. Most commonly, genital ulcer disease is grouped into infectious and noninfectious causes. HSV, syphilis, lymphogranuloma venereum, and chancroid represent some common infectious ulcers. Noninfectious causes on the other hand can be inflammatory, noninflammatory, or malignant (eg, squamous cell carcinoma). Depending on the etiology, genital ulcers may present with unique features that can help clinicians identify the etiology and start treatment in a timely manner. The clinical presentation and management of infectious and noninfectious genital ulcers will be discussed in this review.

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Crohn's disease of the vulva: A prospective study

Abstract: Vulval Crohn's disease is a diagnostic and therapeutic challenge. We recommend consideration of tumor necrosis factor-α inhibitors at an early stage.

Cited by 25 publications

References 16 publications

Non‐infectious granulomatous dermatoses

Non‐infectious granulomatous dermatoses

Cutaneous Crohn’s disease of the vulva after a total colectomy and without gastrointestinal manifestations: A case report

Genital Ulcer Disease: A Review of Pathogenesis and Clinical Features

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